NK2 homeobox 2

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Synonym

NKX2B, NKX2-2, NKX2.2, NK-2 (Drosophila) homolog B, Homeobox protein NK-2 homolog B, Homeobox protein Nkx-2.2

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:4.70 cerebellum:- brain stem:- corpus callosum/glia:29.20 pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
GeneChip cerebrum:7.33 cerebellum:5.99 brain stem:7.74 corpus callosum/glia:8.78 pineal gland:- peripheral nerve:3.66 spine:8.91 retina:- eye:- artery/aorta:3.77 vein:3.66 lymphnode:3.51 peripheral blood:- spleen:3.41 thymus:3.45 bone marrow:3.44 adipose:3.59 bone:- skin:3.58
CAGE cerebrum:2.40 cerebellum:- brain stem:3.19 corpus callosum/glia:3.61 pineal gland:0.51 peripheral nerve:- spine:3.80 retina:- eye:- artery/aorta:0.18 vein:0 lymphnode:0 peripheral blood:- spleen:0 thymus:0 bone marrow:- adipose:0 bone:- skin:-
RNA-seq cerebrum:1.40 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:0 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0.04 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:- esophagus:- stomach:- intestine:- colon:-     liver/hepato:-        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:311.20 breast:- salivary:-
GeneChip uterus:3.44 placenta:3.47 prostate:3.54 ovary:3.45 testis:3.55 heart:3.57 muscle:3.64 esophagus:3.55 stomach:4.75 intestine:4.62 colon:3.82 liver/hepato:3.45 lung:3.51 bladder:- kidney:3.40 pituitary:6.07 thyroid/parathyroid:3.49 adrenal gland:3.50 pancreas:6.40 breast:3.47 salivary:3.39
CAGE uterus:0 placenta:0 prostate:0 ovary:0 testis:0 heart:0 muscle:0 esophagus:0 stomach:- intestine:0.33 colon:0.04     liver/hepato:0    lung:0 bladder:0 kidney:0.08 pituitary:1.09 thyroid/parathyroid:0.06 adrenal gland:- pancreas:0.94 breast:0 salivary:0
RNA-seq uterus:- placenta:- prostate:0.06 ovary:0 testis:0.09 heart:0 muscle:0 esophagus:- stomach:- intestine:- colon:0.05     liver/hepato:0        lung:0    bladder:- kidney:0 pituitary:- thyroid/parathyroid:0 adrenal gland:0 pancreas:- breast:0 salivary:-

Gene Information

IDs

Refseq ID NM_002509
Gene ID 4821
Unigene ID Hs.516922
Probe set ID 206915_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000125820
GTEx ID ENSG00000125820

Orthologous Gene

Mouse[2]  NM_001077632, NM_010919
Rat [0]  

Chromosomal Region

20p11.22  [21,491,648  -  21,494,664]

Gene Family (Interpro ID)

IPR001356  Homeobox
IPR009057  Homeodomain-like
IPR012287  Homeodomain-related

Link to Pubmed  (Pubmed ID)

1346742
9703340
10772886
10818213
11780052
12477932
14573534
15489334
15695521
16697960
16873704
17335795
18029348
18414662
18987169
19011242
20467438
20599218
21481790
21624811
22446943
24411943

Gene Ontology  (GO ID)

Biological Process

GO:0048708  astrocyte differentiation
GO:0007420  brain development
GO:0031018  endocrine pancreas development
GO:0048565  gut development
GO:0045665  negative regulation of neuron differentiation
GO:0048665  neuron fate specification
GO:0014003  oligodendrocyte development
GO:0003326  pancreatic A cell fate commitment
GO:0003323  pancreatic B cell development
GO:0003327  pancreatic B cell fate commitment
GO:0003329  pancreatic PP cell fate commitment
GO:0045666  positive regulation of neuron differentiation
GO:0048714  positive regulation of oligodendrocyte differentiation
GO:0051091  positive regulation of transcription factor activity
GO:0045944  positive regulation of transcription from RNA polymerase II promoter
GO:0007224  smoothened signaling pathway
GO:0021522  spinal cord motor neuron differentiation
GO:0021530  spinal cord oligodendrocyte cell fate specification
GO:0006351  transcription, DNA-dependent
GO:0060580  ventral spinal cord interneuron fate determination

Cellular Component

GO:0005654  nucleoplasm

Molecular Function

GO:0003682  chromatin binding
GO:0043565  sequence-specific DNA binding
GO:0003713  transcription coactivator activity
GO:0003700  transcription factor activity
GO:0008134  transcription factor binding