Notch homolog 2 (Drosophila)

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Synonym

hN2, Neurogenic locus notch homolog protein 2 precursor, Notch 2, Notch (Drosophila) homolog 2, NOTCH2, Notch homolog 2 (Drosophila)

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:71.10 cerebellum:50.40 brain stem:- corpus callosum/glia:29.20 pineal gland:296.70 peripheral nerve:214.70 spine:- retina:237.30 eye:88.20 artery/aorta:30 vein:- lymphnode:70.80 peripheral blood:200.40 spleen:56.70 thymus:64.40 bone marrow:551.10 adipose:121 bone:127.90 skin:120
GeneChip cerebrum:6.71 cerebellum:6.33 brain stem:6.58 corpus callosum/glia:6.79 pineal gland:- peripheral nerve:7.28 spine:7.13 retina:- eye:- artery/aorta:7.26 vein:6.94 lymphnode:6.69 peripheral blood:- spleen:7.34 thymus:6.76 bone marrow:6.98 adipose:7.66 bone:- skin:7.39
CAGE cerebrum:0.43 cerebellum:- brain stem:0.44 corpus callosum/glia:0.39 pineal gland:0.35 peripheral nerve:- spine:0.66 retina:- eye:- artery/aorta:1.82 vein:0.96 lymphnode:0.69 peripheral blood:- spleen:0.92 thymus:0.71 bone marrow:- adipose:0.84 bone:- skin:-
RNA-seq cerebrum:3.12 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:3.71 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:4.00 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:127.60 placenta:145.70 prostate:78.90 ovary:37.30 testis:129.80 heart:140.50 muscle:20.10 esophagus:- stomach:85 intestine:32.40 colon:76.30     liver/hepato:63.30        lung:161.30    bladder:- kidney:114.40 pituitary:- thyroid/parathyroid:- adrenal gland:50.80 pancreas:62.20 breast:362.40 salivary:-
GeneChip uterus:7.57 placenta:7.72 prostate:7.55 ovary:7.93 testis:7.40 heart:7.04 muscle:6.42 esophagus:7.38 stomach:6.87 intestine:6.88 colon:7.23 liver/hepato:6.80 lung:6.99 bladder:- kidney:6.63 pituitary:6.63 thyroid/parathyroid:7.01 adrenal gland:6.88 pancreas:7.17 breast:7.32 salivary:6.82
CAGE uterus:1.02 placenta:0.88 prostate:1.00 ovary:1.06 testis:2.06 heart:1.02 muscle:0.62 esophagus:1.08 stomach:- intestine:0.21 colon:1.12     liver/hepato:0.84    lung:1.06 bladder:0.95 kidney:0.62 pituitary:0.50 thyroid/parathyroid:0.98 adrenal gland:- pancreas:1.42 breast:0 salivary:1.58
RNA-seq uterus:- placenta:- prostate:3.88 ovary:4.60 testis:4.41 heart:2.11 muscle:2.11 esophagus:- stomach:- intestine:- colon:3.56     liver/hepato:3.18        lung:3.85    bladder:- kidney:3.02 pituitary:- thyroid/parathyroid:4.05 adrenal gland:3.47 pancreas:- breast:4.69 salivary:-

IDs

Refseq ID NM_024408
Gene ID 4853
Unigene ID Hs.487360
Probe set ID 210756_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000134250
GTEx ID ENSG00000134250

Orthologous Gene

Mouse[2]  NM_010928
Rat [0]  

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed  (Pubmed ID)

Gene Ontology  (GO ID)

Biological Process

GO:0060413  atrial septum morphogenesis
GO:0046849  bone remodeling
GO:0007050  cell cycle arrest
GO:0001709  cell fate determination
GO:0016049  cell growth
GO:0007368  determination of left/right symmetry
GO:0030326  embryonic limb morphogenesis
GO:0010467  gene expression
GO:0030097  hemopoiesis
GO:0006959  humoral immune response
GO:0001701  in utero embryonic development
GO:0006917  induction of apoptosis
GO:0002437  inflammatory response to antigenic stimulus
GO:0002011  morphogenesis of an epithelial sheet
GO:0007275  multicellular organismal development
GO:0043066  negative regulation of apoptosis
GO:0008285  negative regulation of cell proliferation
GO:0007399  nervous system development
GO:0007220  Notch receptor processing
GO:0007219  Notch signaling pathway
GO:0009887  organ morphogenesis
GO:0060674  placenta blood vessel development
GO:0046579  positive regulation of Ras protein signal transduction
GO:0003184  pulmonary valve morphogenesis
GO:0006355  regulation of transcription, DNA-dependent
GO:0019827  stem cell maintenance
GO:0006367  transcription initiation from RNA polymerase II promoter

Cellular Component

GO:0009986  cell surface
GO:0005789  endoplasmic reticulum membrane
GO:0005576  extracellular region
GO:0000139  Golgi membrane
GO:0005887  integral to plasma membrane
GO:0005654  nucleoplasm
GO:0005634  nucleus
GO:0005886  plasma membrane

Molecular Function

GO:0005509  calcium ion binding
GO:0005515  protein binding
GO:0004872  receptor activity