ATPase, Ca++ transporting, cardiac muscle, fast twitch 1

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Synonym

SR Ca(2+)-ATPase 1, Calcium pump 1, SERCA1, Endoplasmic reticulum class 1/2 Ca(2+) ATPase, ATP2A1, ATP2A

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST nodata
GeneChip cerebrum:4.56 cerebellum:4.42 brain stem:4.53 corpus callosum/glia:4.44 pineal gland:- peripheral nerve:4.40 spine:4.50 retina:- eye:- artery/aorta:4.66 vein:4.82 lymphnode:4.61 peripheral blood:- spleen:4.44 thymus:4.39 bone marrow:4.83 adipose:4.64 bone:- skin:5.83
CAGE cerebrum:0.02 cerebellum:- brain stem:0 corpus callosum/glia:0.07 pineal gland:0 peripheral nerve:- spine:0 retina:- eye:- artery/aorta:1.57 vein:3.84 lymphnode:1.90 peripheral blood:- spleen:0 thymus:0.06 bone marrow:- adipose:4.00 bone:- skin:-
RNA-seq cerebrum:0.00 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:0.00 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0.06 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST nodata
GeneChip uterus:4.49 placenta:4.55 prostate:4.44 ovary:4.56 testis:5.05 heart:4.46 muscle:12.18 esophagus:8.05 stomach:4.37 intestine:5.78 colon:4.68 liver/hepato:4.64 lung:4.48 bladder:- kidney:4.50 pituitary:4.79 thyroid/parathyroid:4.91 adrenal gland:4.54 pancreas:4.73 breast:4.57 salivary:4.64
CAGE uterus:0.16 placenta:0 prostate:0.21 ovary:0 testis:0.16 heart:0.11 muscle:6.86 esophagus:3.61 stomach:- intestine:0 colon:0     liver/hepato:0    lung:0 bladder:0 kidney:0 pituitary:0 thyroid/parathyroid:3.32 adrenal gland:- pancreas:0 breast:0 salivary:2.50
RNA-seq uterus:- placenta:- prostate:0.00 ovary:0.00 testis:0.40 heart:0.00 muscle:7.79 esophagus:- stomach:- intestine:- colon:0.00     liver/hepato:0.00        lung:0.00    bladder:- kidney:0.00 pituitary:- thyroid/parathyroid:6.87 adrenal gland:0.11 pancreas:- breast:6.60 salivary:-

Gene Information

IDs

Refseq ID NM_004320
Gene ID 487
Unigene ID -
Probe set ID 205444_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000196296
GTEx ID ENSG00000196296

Orthologous Gene

Mouse[1]  NM_007504
Rat[1]  NM_007504

Chromosomal Region

16p11.2  [28,889,804  -  28,915,787]

Gene Family (Interpro ID)

IPR005782  ATPase, P-type, calcium-transporting
IPR000695  ATPase, P-type, H+ transporting proton pump
IPR001757  ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter

Link to Pubmed  (Pubmed ID)

1329967
1746562
2842876
2936465
8040329
8729696
8825625
8841193
8889548
9295312
9367679
9405806
9575189
9642673
10551848
10914677
11402072
11438520
11526231
12032137
12477932
12479237
12525698
12692302
12975374
14638697
14702039
15071553
15718407
15767202
15972723
16192278
16410239
16642550
16754798
16933204
17010426
17110338
17728322
18947188
18953100
19061639
19079260
19644701
21145461
21576492
21726808
21890473
21906983
21963094
22505724
22609207
22939629
23911890
24550385
24639526
24816145

Gene Ontology  (GO ID)

Biological Process

GO:0070059  apoptosis in response to endoplasmic reticulum stress
GO:0008637  apoptotic mitochondrial changes
GO:0006200  ATP catabolic process
GO:0007596  blood coagulation
GO:0070509  calcium ion import
GO:0006816  calcium ion transport
GO:0032470  elevation of endoplasmic reticulum calcium ion concentration
GO:0051561  elevation of mitochondrial calcium ion concentration
GO:0034220  ion transmembrane transport
GO:0051659  maintenance of mitochondrion location
GO:0045988  negative regulation of striated muscle contraction
GO:0031448  positive regulation of fast-twitch skeletal muscle fiber contraction
GO:0032471  reduction of endoplasmic reticulum calcium ion concentration
GO:0006942  regulation of striated muscle contraction
GO:0090076  relaxation of skeletal muscle
GO:0034976  response to endoplasmic reticulum stress
GO:0055085  transmembrane transport

Cellular Component

GO:0034704  calcium channel complex
GO:0005789  endoplasmic reticulum membrane
GO:0005793  ER-Golgi intermediate compartment
GO:0031673  H zone
GO:0031674  I band
GO:0016021  integral to membrane
GO:0016020  membrane
GO:0048471  perinuclear region of cytoplasm
GO:0031095  platelet dense tubular network membrane
GO:0016529  sarcoplasmic reticulum
GO:0033017  sarcoplasmic reticulum membrane

Molecular Function

GO:0005524  ATP binding
GO:0005509  calcium ion binding
GO:0005388  calcium-transporting ATPase activity
GO:0005515  protein binding
GO:0042803  protein homodimerization activity