natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A)

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Synonym

NPR1, ANPa, NPR-A, ANPRA, GUC2A, Atrial natriuretic peptide A-type receptor, NPRA, GUCY2A

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:5.90 cerebellum:50.40 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:30.70 spine:336.90 retina:- eye:11.80 artery/aorta:60 vein:66.60 lymphnode:- peripheral blood:- spleen:- thymus:25.80 bone marrow:- adipose:161.30 bone:12.80 skin:-
GeneChip cerebrum:6.36 cerebellum:6.56 brain stem:6.47 corpus callosum/glia:6.41 pineal gland:- peripheral nerve:6.10 spine:6.05 retina:- eye:- artery/aorta:7.67 vein:6.88 lymphnode:6.40 peripheral blood:- spleen:6.01 thymus:5.99 bone marrow:6.49 adipose:7.42 bone:- skin:6.69
CAGE cerebrum:1.21 cerebellum:- brain stem:0.91 corpus callosum/glia:0.99 pineal gland:1.69 peripheral nerve:- spine:1.84 retina:- eye:- artery/aorta:5.80 vein:4.29 lymphnode:2.52 peripheral blood:- spleen:1.65 thymus:1.31 bone marrow:- adipose:4.76 bone:- skin:-
RNA-seq cerebrum:0.19 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:3.68 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:4.88 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:173.20 placenta:91.10 prostate:- ovary:- testis:26 heart:25.50 muscle:20.10 esophagus:- stomach:- intestine:129.60 colon:-     liver/hepato:-        lung:48.90    bladder:- kidney:52 pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:566.90 salivary:-
GeneChip uterus:6.56 placenta:6.47 prostate:6.09 ovary:7.35 testis:6.09 heart:6.96 muscle:6.63 esophagus:6.66 stomach:6.50 intestine:6.67 colon:6.82 liver/hepato:6.62 lung:7 bladder:- kidney:6.85 pituitary:6.37 thyroid/parathyroid:6.28 adrenal gland:6.79 pancreas:6.96 breast:6.65 salivary:6.64
CAGE uterus:3.58 placenta:3.52 prostate:2.87 ovary:4.13 testis:2.64 heart:4.21 muscle:3.06 esophagus:3.37 stomach:- intestine:2.46 colon:3.26     liver/hepato:2.42    lung:4.56 bladder:3.64 kidney:4.46 pituitary:2.82 thyroid/parathyroid:3.01 adrenal gland:- pancreas:2.60 breast:5.76 salivary:1.82
RNA-seq uterus:- placenta:- prostate:3.21 ovary:4.53 testis:2.72 heart:1.88 muscle:1.01 esophagus:- stomach:- intestine:- colon:4.02     liver/hepato:2.43        lung:3.79    bladder:- kidney:4.39 pituitary:- thyroid/parathyroid:2.69 adrenal gland:3.22 pancreas:- breast:5.10 salivary:-

Gene Information

IDs

Refseq ID NM_000906
Gene ID 4881
Unigene ID Hs.490330
Probe set ID 204648_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000169418
GTEx ID ENSG00000169418

Orthologous Gene

Mouse[1]  NM_008727
Rat [0]  

Chromosomal Region

1q21.3  [153,651,113  -  153,666,468]

Gene Family (Interpro ID)

IPR001828  Extracellular ligand-binding receptor
IPR001170  Natriuretic peptide receptor, N-terminal
IPR000719  Protein kinase, catalytic domain
IPR011009  Protein kinase-like domain
IPR002290  Serine/threonine-protein kinase domain
IPR017442  Serine/threonine-protein kinase-like domain
IPR001245  Tyrosine-protein kinase, catalytic domain
IPR020635  Tyrosine-protein kinase, subgroup, catalytic domain

Link to Pubmed  (Pubmed ID)

1309330
1660465
1672777
1979052
2569967
7601467
7857923
7901875
7954658
7982997
8786123
9405681
9528788
9618281
10581150
11704663
11851379
11952097
12121994
12135318
12477932
12483301
12506509
12547834
12727915
12794112
12855709
12872042
14646971
14737067
14960748
15231748
15459247
15489334
15911067
15911069
15911610
16262696
16710414
16778132
16875975
16986166
17460430
17672826
18306933
18360023
18383440
18436476
18713751
19086053
19126660
19165164
19326473
19458086
19563399
19679847
20024606
20034689
20360068
20452482
20529973
20673868
20700369
20977274
21366551
21375691
21586128
21828054
21963094
22001395
22133375
22949736
23186809
24699414

Gene Ontology  (GO ID)

Biological Process

GO:0007589  body fluid secretion
GO:0007166  cell surface receptor linked signal transduction
GO:0006182  cGMP biosynthetic process
GO:0042417  dopamine metabolic process
GO:0016525  negative regulation of angiogenesis
GO:0030308  negative regulation of cell growth
GO:0048662  negative regulation of smooth muscle cell proliferation
GO:0030828  positive regulation of cGMP biosynthetic process
GO:0007168  receptor guanylyl cyclase signaling pathway
GO:0008217  regulation of blood pressure
GO:0050880  regulation of blood vessel size
GO:0043114  regulation of vascular permeability
GO:0042312  regulation of vasodilation

Cellular Component

GO:0005887  integral to plasma membrane

Molecular Function

GO:0005524  ATP binding
GO:0005525  GTP binding
GO:0004383  guanylate cyclase activity
GO:0042562  hormone binding
GO:0016941  natriuretic peptide receptor activity
GO:0017046  peptide hormone binding
GO:0008528  peptide receptor activity, G-protein coupled
GO:0004672  protein kinase activity
GO:0019901  protein kinase binding