solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2

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Synonym

Divalent metal transporter 1, NRAMP 2, FLJ37416, OK/SW-cl.20, NRAMP2, Natural resistance-associated macrophage protein 2, DCT1, SLC11A2

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:180.10 cerebellum:251.90 brain stem:- corpus callosum/glia:145.80 pineal gland:- peripheral nerve:- spine:224.60 retina:- eye:76.40 artery/aorta:60 vein:- lymphnode:40.40 peripheral blood:127.50 spleen:56.70 thymus:193.30 bone marrow:- adipose:- bone:51.20 skin:91.20
GeneChip cerebrum:6.88 cerebellum:6.93 brain stem:6.81 corpus callosum/glia:7.37 pineal gland:- peripheral nerve:6.78 spine:7.33 retina:- eye:- artery/aorta:6.50 vein:6.37 lymphnode:6.55 peripheral blood:- spleen:6.71 thymus:7.22 bone marrow:7.42 adipose:6.68 bone:- skin:6.72
CAGE cerebrum:3.56 cerebellum:- brain stem:4.24 corpus callosum/glia:4.33 pineal gland:3.15 peripheral nerve:- spine:4.20 retina:- eye:- artery/aorta:3.09 vein:2.71 lymphnode:3.16 peripheral blood:- spleen:2.39 thymus:3.29 bone marrow:- adipose:3.17 bone:- skin:-
RNA-seq cerebrum:3.03 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:0.00 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:1.97 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:164 placenta:163.90 prostate:11.30 ovary:74.50 testis:103.80 heart:- muscle:60.30 esophagus:- stomach:- intestine:- colon:50.90     liver/hepato:10.60        lung:215.10    bladder:251.20 kidney:72.80 pituitary:- thyroid/parathyroid:- adrenal gland:50.80 pancreas:26.70 breast:37.20 salivary:656.80
GeneChip uterus:6.70 placenta:7.36 prostate:6.92 ovary:6.80 testis:6.51 heart:6.55 muscle:6.77 esophagus:7.05 stomach:6.85 intestine:7.07 colon:6.94 liver/hepato:6.73 lung:6.87 bladder:- kidney:6.80 pituitary:6.53 thyroid/parathyroid:7.03 adrenal gland:6.50 pancreas:7.65 breast:6.91 salivary:7.15
CAGE uterus:3.26 placenta:3.44 prostate:3.10 ovary:2.72 testis:3.02 heart:2.80 muscle:2.50 esophagus:3.05 stomach:- intestine:2.95 colon:3.06     liver/hepato:2.64    lung:3.26 bladder:2.80 kidney:3.24 pituitary:3.64 thyroid/parathyroid:3.48 adrenal gland:- pancreas:3.23 breast:3.02 salivary:3.64
RNA-seq uterus:- placenta:- prostate:0.00 ovary:0.83 testis:1.28 heart:0.00 muscle:0.00 esophagus:- stomach:- intestine:- colon:0.80     liver/hepato:0.00        lung:0.00    bladder:- kidney:0.82 pituitary:- thyroid/parathyroid:2.92 adrenal gland:0.00 pancreas:- breast:0.00 salivary:-

Gene Information

IDs

Refseq ID NM_000617
Gene ID 4891
Unigene ID Hs.505545
Probe set ID 203125_x_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000110911
GTEx ID ENSG00000110911

Orthologous Gene

Mouse[4]  NM_001146161, NM_008732
Rat [0]  

Chromosomal Region

12q13.12  [51,373,184  -  51,422,349]

Gene Family (Interpro ID)

IPR001046  Natural resistance-associated macrophage protein

Link to Pubmed  (Pubmed ID)

7613023
9241278
9464519
9642100
9790986
10625641
10751401
10984552
11095929
11439223
11755534
11842004
11891802
11897618
11943663
12127992
12139757
12209011
12475959
12477932
12662899
12734107
12949720
12949888
12973678
14702039
14768003
15024413
15139022
15223008
15459009
15489334
15636493
15644277
15792797
15880641
16123094
16344560
16439678
17109629
17293870
17510944
17932044
17980698
18082289
18419598
18667808
18776082
18876082
19679638
19706893
19913121
19946888
20007457
20089134
20152801
20164305
20379614
20410187
20587610
20628086
20945371
21074515
21199652
21276595
21777657
21798283
21871825
21947861
21948377
22068728
22137264
22154351
22310887
22371024
22383495
22509377
22666436
22736759
23016933
23996061
24448823

Gene Ontology  (GO ID)

Biological Process

GO:0006919  activation of caspase activity
GO:0070574  cadmium ion transmembrane transport
GO:0006879  cellular iron ion homeostasis
GO:0034599  cellular response to oxidative stress
GO:0006824  cobalt ion transport
GO:0006825  copper ion transport
GO:0048813  dendrite morphogenesis
GO:0003032  detection of oxygen
GO:0048821  erythrocyte development
GO:0070627  ferrous iron import
GO:0015684  ferrous iron transport
GO:0006783  heme biosynthetic process
GO:0015692  lead ion transport
GO:0007611  learning or memory
GO:0071421  manganese ion transmembrane transport
GO:0006828  manganese ion transport
GO:0060586  multicellular organismal iron ion homeostasis
GO:0015675  nickel ion transport
GO:0001666  response to hypoxia
GO:0010039  response to iron ion
GO:0055085  transmembrane transport
GO:0015676  vanadium ion transport

Cellular Component

GO:0045177  apical part of cell
GO:0016324  apical plasma membrane
GO:0045178  basal part of cell
GO:0005903  brush border
GO:0009986  cell surface
GO:0005737  cytoplasm
GO:0031410  cytoplasmic vesicle
GO:0005769  early endosome
GO:0012505  endomembrane system
GO:0005887  integral to plasma membrane
GO:0005770  late endosome
GO:0031902  late endosome membrane
GO:0005765  lysosomal membrane
GO:0005764  lysosome
GO:0005634  nucleus
GO:0070826  paraferritin complex
GO:0048471  perinuclear region of cytoplasm
GO:0005886  plasma membrane
GO:0055037  recycling endosome
GO:0005802  trans-Golgi network
GO:0005773  vacuole

Molecular Function

GO:0015086  cadmium ion transmembrane transporter activity
GO:0015085  calcium ion transmembrane transporter activity
GO:0070835  chromium ion transmembrane transporter activity
GO:0015087  cobalt ion transmembrane transporter activity
GO:0005375  copper ion transmembrane transporter activity
GO:0015093  ferrous iron transmembrane transporter activity
GO:0015078  hydrogen ion transmembrane transporter activity
GO:0022890  inorganic cation transmembrane transporter activity
GO:0015094  lead ion transmembrane transporter activity
GO:0005384  manganese ion transmembrane transporter activity
GO:0015099  nickel ion transmembrane transporter activity
GO:0005515  protein binding
GO:0015295  solute:hydrogen symporter activity
GO:0015100  vanadium ion transmembrane transporter activity
GO:0005385  zinc ion transmembrane transporter activity