ATPase, Ca++ transporting, plasma membrane 2

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Synonym

Plasma membrane calcium-transporting ATPase 2, ATPase, Ca++ transporting, plasma membrane 2, Plasma membrane calcium ATPase isoform 2, PMCA2, Ca++ transporting, ATP2B2, Plasma membrane calcium pump isoform 2

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:110.20 cerebellum:201.50 brain stem:- corpus callosum/glia:58.30 pineal gland:296.70 peripheral nerve:- spine:112.30 retina:- eye:29.40 artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:56.70 thymus:- bone marrow:19.70 adipose:- bone:- skin:19.20
GeneChip cerebrum:9.31 cerebellum:10.29 brain stem:8.73 corpus callosum/glia:6.95 pineal gland:- peripheral nerve:7.42 spine:7.57 retina:- eye:- artery/aorta:4.91 vein:5.07 lymphnode:4.87 peripheral blood:- spleen:4.83 thymus:4.65 bone marrow:5.06 adipose:5.14 bone:- skin:4.75
CAGE cerebrum:4.75 cerebellum:- brain stem:3.46 corpus callosum/glia:3.16 pineal gland:4.68 peripheral nerve:- spine:2.74 retina:- eye:- artery/aorta:0.79 vein:0.18 lymphnode:0.06 peripheral blood:- spleen:0 thymus:0.23 bone marrow:- adipose:0.26 bone:- skin:-
RNA-seq cerebrum:0.91 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:0.00 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0.00 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:3.60 prostate:- ovary:- testis:13 heart:- muscle:40.20 esophagus:- stomach:- intestine:- colon:8.50     liver/hepato:10.60        lung:-    bladder:- kidney:10.40 pituitary:- thyroid/parathyroid:- adrenal gland:50.80 pancreas:- breast:- salivary:-
GeneChip uterus:5.34 placenta:4.90 prostate:4.28 ovary:5.55 testis:4.72 heart:4.98 muscle:7.41 esophagus:5.12 stomach:4.88 intestine:5.32 colon:5.31 liver/hepato:7.96 lung:4.78 bladder:- kidney:5.11 pituitary:6.43 thyroid/parathyroid:4.88 adrenal gland:5.34 pancreas:5.09 breast:4.82 salivary:8.75
CAGE uterus:1.31 placenta:0 prostate:0 ovary:0.60 testis:0.85 heart:0.04 muscle:0.24 esophagus:0.09 stomach:- intestine:0.21 colon:0.15     liver/hepato:3.68    lung:0 bladder:0 kidney:0.08 pituitary:2.00 thyroid/parathyroid:0 adrenal gland:- pancreas:0.58 breast:0 salivary:4.07
RNA-seq uterus:- placenta:- prostate:0.00 ovary:0.07 testis:0.06 heart:0.00 muscle:0.00 esophagus:- stomach:- intestine:- colon:0.00     liver/hepato:0.41        lung:0.00    bladder:- kidney:0.00 pituitary:- thyroid/parathyroid:0.00 adrenal gland:0.00 pancreas:- breast:0.00 salivary:-

Gene Information

IDs

Refseq ID NM_001001331
Gene ID 491
Unigene ID Hs.268942
Probe set ID 204685_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000157087
GTEx ID ENSG00000157087

Orthologous Gene

Mouse[6]  NM_001036684, NM_009723
Rat [0]  

Chromosomal Region

3p25.3  [10,365,707  -  10,749,716]

Gene Family (Interpro ID)

IPR006069  ATPase, P-type cation exchange, alpha subunit
IPR006408  ATPase, P-type, calcium-transporting, PMCA-type
IPR001757  ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter

Link to Pubmed  (Pubmed ID)

1313367
1427863
1827443
7929331
7989379
8162598
8187550
8245032
8428366
8634322
9668038
9697703
11152753
11259493
11274188
11786550
12107410
12477932
12624087
12763866
12784250
15071553
15101689
15123239
15765049
15829536
15926914
16216224
17234811
17488275
19043545
19299509
19379709
19850283
19913121
20211863
20301607
20379614
20628086
20663896
20971118
21672522
21757185
21890473
21906983
21963094
21987572
22047666
22053931
22349217
23000965
23620727
24639526

Gene Ontology  (GO ID)

Biological Process

GO:0060088  auditory receptor cell stereocilium organization
GO:0007596  blood coagulation
GO:0006816  calcium ion transport
GO:0021707  cerebellar granule cell differentiation
GO:0021702  cerebellar Purkinje cell differentiation
GO:0046068  cGMP metabolic process
GO:0090102  cochlea development
GO:0051480  cytosolic calcium ion homeostasis
GO:0050910  detection of mechanical stimulus involved in sensory perception of sound
GO:0034220  ion transmembrane transport
GO:0007595  lactation
GO:0040011  locomotion
GO:0007626  locomotory behavior
GO:0050885  neuromuscular process controlling balance
GO:0030182  neuron differentiation
GO:0006996  organelle organization
GO:0045299  otolith mineralization
GO:0051928  positive regulation of calcium ion transport
GO:0008361  regulation of cell size
GO:0048167  regulation of synaptic plasticity
GO:0007605  sensory perception of sound
GO:0042428  serotonin metabolic process
GO:0050808  synapse organization
GO:0055085  transmembrane transport
GO:0006810  transport

Cellular Component

GO:0016324  apical plasma membrane
GO:0043025  cell soma
GO:0005929  cilium
GO:0005737  cytoplasm
GO:0005783  endoplasmic reticulum
GO:0016021  integral to membrane
GO:0005886  plasma membrane

Molecular Function

GO:0005524  ATP binding
GO:0005509  calcium ion binding
GO:0030899  calcium-dependent ATPase activity
GO:0005388  calcium-transporting ATPase activity
GO:0005516  calmodulin binding
GO:0046872  metal ion binding
GO:0030165  PDZ domain binding
GO:0005515  protein binding
GO:0008022  protein C-terminus binding