neurotrophic tyrosine kinase, receptor, type 3

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Synonym

neurotrophic tyrosine kinase, receptor, type 3, gp145(trkC), TRKC, NTRK3, Neurotrophic tyrosine kinase receptor type 3, Trk-C, GP145-TrkC, NT-3 growth factor receptor precursor, TrkC tyrosine kinase

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST nodata
GeneChip cerebrum:7.98 cerebellum:7.80 brain stem:7.48 corpus callosum/glia:6.44 pineal gland:- peripheral nerve:8.98 spine:6.99 retina:- eye:- artery/aorta:7.42 vein:7.24 lymphnode:4.73 peripheral blood:- spleen:4.53 thymus:4.52 bone marrow:4.74 adipose:5.16 bone:- skin:4.81
CAGE cerebrum:4.79 cerebellum:- brain stem:4.33 corpus callosum/glia:3.97 pineal gland:3.91 peripheral nerve:- spine:4.62 retina:- eye:- artery/aorta:4.64 vein:3.04 lymphnode:1.70 peripheral blood:- spleen:1.83 thymus:1.12 bone marrow:- adipose:3.03 bone:- skin:-
RNA-seq cerebrum:0.00 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:0.00 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0.00 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST nodata
GeneChip uterus:5.34 placenta:4.31 prostate:5.23 ovary:4.91 testis:4.43 heart:4.93 muscle:5.07 esophagus:4.90 stomach:4.75 intestine:4.89 colon:5.09 liver/hepato:4.35 lung:5.13 bladder:- kidney:4.82 pituitary:5.31 thyroid/parathyroid:4.66 adrenal gland:5.11 pancreas:4.53 breast:5.12 salivary:4.87
CAGE uterus:3.61 placenta:0.85 prostate:2.60 ovary:3.02 testis:2.93 heart:2.86 muscle:1.48 esophagus:1.80 stomach:- intestine:1.41 colon:2.33     liver/hepato:0.90    lung:2.40 bladder:2.87 kidney:2.64 pituitary:3.19 thyroid/parathyroid:1.52 adrenal gland:- pancreas:0 breast:3.12 salivary:2.35
RNA-seq uterus:- placenta:- prostate:0.00 ovary:0.00 testis:0.00 heart:0.00 muscle:0.00 esophagus:- stomach:- intestine:- colon:0.00     liver/hepato:0.00        lung:0.00    bladder:- kidney:0.07 pituitary:- thyroid/parathyroid:0.00 adrenal gland:0.00 pancreas:- breast:0.00 salivary:-

Gene Information

IDs

Refseq ID NM_002530
Gene ID 4916
Unigene ID -
Probe set ID 215311_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000140538
GTEx ID ENSG00000140538

Orthologous Gene

Mouse[4]  NM_008746, NM_182809
Rat[1]  NM_019248, NM_182809

Chromosomal Region

15q25.3  [88,402,982  -  88,799,978]

Gene Family (Interpro ID)

IPR000719  Protein kinase, catalytic domain
IPR011009  Protein kinase-like domain
IPR002290  Serine/threonine-protein kinase domain
IPR017442  Serine/threonine-protein kinase-like domain
IPR020685  Tyrosine-protein kinase
IPR001245  Tyrosine-protein kinase, catalytic domain
IPR020933  Tyrosine-protein kinase, fibroblast growth factor receptor, conserved region
IPR020777  Tyrosine-protein kinase, neurotrophic receptor
IPR020635  Tyrosine-protein kinase, subgroup, catalytic domain

Link to Pubmed  (Pubmed ID)

1326636
1653651
7657612
7806211
7823156
7828539
8344249
8619474
8621424
8889548
8895847
9110174
9195161
9197281
9462753
9488719
9648868
9778053
9856458
9927421
9973222
10027399
10092678
10764727
11157096
11205744
11877382
12006576
12034707
12210087
12237455
12399943
12450792
12471037
12477932
12927579
14668342
15167446
15167895
15198123
15247919
15312164
15513915
15932601
16344560
16537434
16647839
16648236
16786155
16826429
16862449
16941478
17971243
18068631
18179783
18203754
18293376
18319596
18336001
18347002
18367154
18428117
18616610
18639687
18713973
19011601
19040714
19086053
19156760
19179422
19187638
19344762
19351817
19370765
19417027
19453261
19556619
19598235
19680743
19893451
20078941
20160348
20219210
20379614
20554328
20802235
21070662
21139137
21295543
21392742
21401966
21552290
21617231
21728718
21788388
21832049
21988832
22265740
22343487
22388998
22404213
22939624
23027130
23332094
23341610
23416450
23453885
23727532
23832765
23869086
23874207
24145651
24327398
24722188

Gene Ontology  (GO ID)

Biological Process

GO:0000187  activation of MAPK activity
GO:0032148  activation of protein kinase B activity
GO:0032856  activation of Ras GTPase activity
GO:0071300  cellular response to retinoic acid
GO:0090102  cochlea development
GO:0042490  mechanoreceptor differentiation
GO:0019056  modulation by virus of host transcription
GO:0048712  negative regulation of astrocyte differentiation
GO:0060548  negative regulation of cell death
GO:0001933  negative regulation of protein amino acid phosphorylation
GO:0048665  neuron fate specification
GO:0001764  neuron migration
GO:0048691  positive regulation of axon extension involved in regeneration
GO:0030335  positive regulation of cell migration
GO:0008284  positive regulation of cell proliferation
GO:0010628  positive regulation of gene expression
GO:0033138  positive regulation of peptidyl-serine phosphorylation
GO:0050927  positive regulation of positive chemotaxis
GO:0046777  protein amino acid autophosphorylation
GO:0048678  response to axon injury
GO:0051412  response to corticosterone stimulus
GO:0045471  response to ethanol
GO:0007169  transmembrane receptor protein tyrosine kinase signaling pathway

Cellular Component

GO:0005737  cytoplasm
GO:0005887  integral to plasma membrane

Molecular Function

GO:0005524  ATP binding
GO:0046875  ephrin receptor binding
GO:0043121  neurotrophin binding
GO:0005030  neurotrophin receptor activity
GO:0002039  p53 binding
GO:0004714  transmembrane receptor protein tyrosine kinase activity