discoidin domain receptor tyrosine kinase 2

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Synonym

CD167b antigen, Discoidin domain receptor 2, TYRO10, TKT, Neurotrophic tyrosine kinase, receptor-related 3, DDR2, NTRKR3, Discoidin domain-containing receptor 2 precursor, Receptor protein-tyrosine kinase TKT, discoidin domain receptor family, member 2, Tyrosine-protein kinase TYRO 10, MIG20a

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:17.80 cerebellum:25.20 brain stem:- corpus callosum/glia:58.30 pineal gland:- peripheral nerve:92 spine:- retina:237.30 eye:35.30 artery/aorta:179.90 vein:333.20 lymphnode:- peripheral blood:- spleen:- thymus:12.90 bone marrow:39.40 adipose:121 bone:38.40 skin:38.40
GeneChip cerebrum:6.18 cerebellum:6.13 brain stem:6.36 corpus callosum/glia:6.88 pineal gland:- peripheral nerve:7.64 spine:7.18 retina:- eye:- artery/aorta:8.44 vein:7.97 lymphnode:7.01 peripheral blood:- spleen:6.33 thymus:5.92 bone marrow:6.03 adipose:8.64 bone:- skin:7.05
CAGE cerebrum:2.38 cerebellum:- brain stem:2.94 corpus callosum/glia:3.21 pineal gland:2.84 peripheral nerve:- spine:3.82 retina:- eye:- artery/aorta:4.28 vein:3.66 lymphnode:2.54 peripheral blood:- spleen:2.30 thymus:0.64 bone marrow:- adipose:4.68 bone:- skin:-
RNA-seq cerebrum:1.83 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:2.85 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:3.29 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:82 placenta:32.80 prostate:56.30 ovary:111.80 testis:13 heart:51.10 muscle:- esophagus:- stomach:191.20 intestine:32.40 colon:25.40     liver/hepato:21.10        lung:63.50    bladder:- kidney:10.40 pituitary:116 thyroid/parathyroid:- adrenal gland:355.50 pancreas:- breast:- salivary:-
GeneChip uterus:8.05 placenta:6.46 prostate:7.19 ovary:7.63 testis:6.06 heart:7.54 muscle:6.49 esophagus:7.26 stomach:7.70 intestine:6.51 colon:7.38 liver/hepato:6.07 lung:6.98 bladder:- kidney:6.03 pituitary:6.47 thyroid/parathyroid:6.87 adrenal gland:9.08 pancreas:5.95 breast:7.49 salivary:6.30
CAGE uterus:4.30 placenta:2.51 prostate:4.08 ovary:4.21 testis:2.81 heart:3.52 muscle:2.27 esophagus:4.15 stomach:- intestine:3.15 colon:3.81     liver/hepato:1.74    lung:3.20 bladder:4.30 kidney:2.27 pituitary:2.30 thyroid/parathyroid:3.07 adrenal gland:- pancreas:1.21 breast:3.76 salivary:2.35
RNA-seq uterus:- placenta:- prostate:3.23 ovary:3.62 testis:2.54 heart:2.33 muscle:1.03 esophagus:- stomach:- intestine:- colon:3.94     liver/hepato:0.56        lung:2.79    bladder:- kidney:1.42 pituitary:- thyroid/parathyroid:2.43 adrenal gland:2.41 pancreas:- breast:4.70 salivary:-

Gene Information

IDs

Refseq ID NM_006182
Gene ID 4921
Unigene ID Hs.593833
Probe set ID 205168_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000162733
GTEx ID ENSG00000162733

Orthologous Gene

Mouse[2]  NM_022563
Rat[1]  NM_031764

Chromosomal Region

1q23.3  [162,601,163  -  162,750,237]

Gene Family (Interpro ID)

IPR000421  Coagulation factor 5/8 type, C-terminal
IPR008979  Galactose-binding domain-like
IPR000719  Protein kinase, catalytic domain
IPR011009  Protein kinase-like domain
IPR002290  Serine/threonine-protein kinase domain
IPR017442  Serine/threonine-protein kinase-like domain
IPR001245  Tyrosine-protein kinase, catalytic domain
IPR020635  Tyrosine-protein kinase, subgroup, catalytic domain

Link to Pubmed  (Pubmed ID)

1486804
1567394
7774938
8125298
8247548
8889549
9659899
11133186
11884411
12477932
12935821
14702039
15111304
15544808
16186104
16186108
16626936
16806867
16967187
17299390
17703188
17786355
17968949
18201965
19110212
19322201
19415460
19536175
20223752
20379614
20564243
20628624
21139048
21335558
21477649
21701781
21963094
22328973
22832484
22939624
23131558
23233663
23307244
23401445
23546533
23644467
23822953
24018687
24293323
24631539
24725993

Gene Ontology  (GO ID)

Biological Process

GO:0031214  biomineral formation
GO:0007155  cell adhesion
GO:0030199  collagen fibril organization
GO:0003416  endochondral bone growth
GO:0030198  extracellular matrix organization
GO:0001503  ossification
GO:0018108  peptidyl-tyrosine phosphorylation
GO:0090091  positive regulation of extracellular matrix disassembly
GO:0010763  positive regulation of fibroblast migration
GO:0048146  positive regulation of fibroblast proliferation
GO:0045669  positive regulation of osteoblast differentiation
GO:0045860  positive regulation of protein kinase activity
GO:0051091  positive regulation of transcription factor activity
GO:0046777  protein amino acid autophosphorylation
GO:0030500  regulation of bone mineralization
GO:0010715  regulation of extracellular matrix disassembly
GO:0007165  signal transduction

Cellular Component

GO:0005887  integral to plasma membrane
GO:0005886  plasma membrane

Molecular Function

GO:0005524  ATP binding
GO:0005518  collagen binding
GO:0005515  protein binding
GO:0004714  transmembrane receptor protein tyrosine kinase activity