oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)

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Synonym

AKGDH, E1k, Alpha-ketoglutarate dehydrogenase, OGDH, OGDC

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:295.10 cerebellum:579.30 brain stem:- corpus callosum/glia:233.30 pineal gland:- peripheral nerve:61.30 spine:- retina:237.30 eye:170.40 artery/aorta:60 vein:933.10 lymphnode:70.80 peripheral blood:164 spleen:75.60 thymus:141.70 bone marrow:177.10 adipose:201.70 bone:89.60 skin:182.40
GeneChip cerebrum:7.29 cerebellum:7.19 brain stem:7.46 corpus callosum/glia:7.10 pineal gland:- peripheral nerve:7.57 spine:7.29 retina:- eye:- artery/aorta:7.68 vein:7.53 lymphnode:7.27 peripheral blood:- spleen:7.56 thymus:7.09 bone marrow:7.06 adipose:7.50 bone:- skin:7.41
CAGE cerebrum:3.60 cerebellum:- brain stem:3.59 corpus callosum/glia:3.69 pineal gland:3.37 peripheral nerve:- spine:3.34 retina:- eye:- artery/aorta:3.56 vein:3.46 lymphnode:3.45 peripheral blood:- spleen:3.18 thymus:3.21 bone marrow:- adipose:3.49 bone:- skin:-
RNA-seq cerebrum:4.21 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:4.13 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:4.55 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:246.10 placenta:218.60 prostate:180.20 ovary:37.30 testis:220.60 heart:166 muscle:160.70 esophagus:- stomach:212.40 intestine:64.80 colon:169.60     liver/hepato:105.60        lung:263.90    bladder:- kidney:156 pituitary:- thyroid/parathyroid:491.20 adrenal gland:203.10 pancreas:124.50 breast:306.70 salivary:-
GeneChip uterus:7.11 placenta:7.50 prostate:7.33 ovary:6.76 testis:7.23 heart:8.73 muscle:8.16 esophagus:8.24 stomach:7.50 intestine:7.33 colon:7.45 liver/hepato:7.59 lung:7.29 bladder:- kidney:8.61 pituitary:7.12 thyroid/parathyroid:7.90 adrenal gland:7.69 pancreas:6.23 breast:7.49 salivary:7.20
CAGE uterus:3.44 placenta:3.51 prostate:3.23 ovary:3.27 testis:3.46 heart:4.38 muscle:4.85 esophagus:3.64 stomach:- intestine:4.41 colon:3.87     liver/hepato:3.49    lung:3.39 bladder:3.20 kidney:4.03 pituitary:3.22 thyroid/parathyroid:3.70 adrenal gland:- pancreas:3.34 breast:3.43 salivary:4.16
RNA-seq uterus:- placenta:- prostate:4.66 ovary:4.48 testis:4.47 heart:6.53 muscle:6.74 esophagus:- stomach:- intestine:- colon:4.25     liver/hepato:3.64        lung:4.49    bladder:- kidney:5.36 pituitary:- thyroid/parathyroid:6.05 adrenal gland:4.45 pancreas:- breast:5.24 salivary:-

Gene Information

IDs

Refseq ID NM_002541
Gene ID 4967
Unigene ID Hs.488181
Probe set ID 201282_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000105953
GTEx ID ENSG00000105953

Orthologous Gene

Mouse[3]  NM_010956
Rat[1]  NM_001017461

Chromosomal Region

7p13  [44,646,171  -  44,748,665]

Gene Family (Interpro ID)

-

Link to Pubmed  (Pubmed ID)

1542694
2188967
7622061
8020988
8889548
9727038
9847074
12477932
15466852
15649899
16009940
16189514
16344560
17000644
17343268
17370265
17456239
18029348
18781797
19615732
20877624
21139048
21611730
21890473
22169199
22939629
23475850
23874603
24654937
24816145

Gene Ontology  (GO ID)

Biological Process

GO:0006103  2-oxoglutarate metabolic process
GO:0044237  cellular metabolic process
GO:0034641  cellular nitrogen compound metabolic process
GO:0021695  cerebellar cortex development
GO:0006091  generation of precursor metabolites and energy
GO:0006096  glycolysis
GO:0021766  hippocampus development
GO:0006554  lysine catabolic process
GO:0006734  NADH metabolic process
GO:0021860  pyramidal neuron development
GO:0021756  striatum development
GO:0006104  succinyl-CoA metabolic process
GO:0022028  tangential migration from the subventricular zone to the olfactory bulb
GO:0021794  thalamus development
GO:0006099  tricarboxylic acid cycle

Cellular Component

GO:0005759  mitochondrial matrix
GO:0031966  mitochondrial membrane
GO:0005739  mitochondrion
GO:0045252  oxoglutarate dehydrogenase complex

Molecular Function

GO:0051087  chaperone binding
GO:0031072  heat shock protein binding
GO:0034602  oxoglutarate dehydrogenase (NAD+) activity
GO:0004591  oxoglutarate dehydrogenase (succinyl-transferring) activity
GO:0030976  thiamin pyrophosphate binding