purinergic receptor P2X, ligand-gated ion channel, 4

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Synonym

P2X purinoceptor 4, P2X4R, P2X4, P2RX4

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:13 cerebellum:88.20 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:30.70 spine:- retina:- eye:11.80 artery/aorta:- vein:- lymphnode:30.30 peripheral blood:255.10 spleen:75.60 thymus:- bone marrow:- adipose:- bone:51.20 skin:9.60
GeneChip cerebrum:6.01 cerebellum:7.20 brain stem:6.10 corpus callosum/glia:6.13 pineal gland:- peripheral nerve:6.14 spine:6.26 retina:- eye:- artery/aorta:6.25 vein:6.20 lymphnode:6.30 peripheral blood:- spleen:6.37 thymus:5.95 bone marrow:6.25 adipose:6.32 bone:- skin:6.08
CAGE cerebrum:1.87 cerebellum:- brain stem:1.86 corpus callosum/glia:2.23 pineal gland:1.18 peripheral nerve:- spine:1.88 retina:- eye:- artery/aorta:2.50 vein:2.16 lymphnode:2.38 peripheral blood:- spleen:2.23 thymus:1.43 bone marrow:- adipose:2.64 bone:- skin:-
RNA-seq cerebrum:1.32 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:3.04 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:2.70 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:9.10 placenta:94.70 prostate:22.50 ovary:- testis:30.30 heart:38.30 muscle:- esophagus:- stomach:- intestine:32.40 colon:93.30     liver/hepato:31.70        lung:29.30    bladder:- kidney:41.60 pituitary:- thyroid/parathyroid:- adrenal gland:50.80 pancreas:71.10 breast:9.30 salivary:-
GeneChip uterus:6.37 placenta:8.17 prostate:7.09 ovary:6.74 testis:6.20 heart:6 muscle:5.59 esophagus:5.54 stomach:6.59 intestine:7.18 colon:7.08 liver/hepato:6.02 lung:6.94 bladder:- kidney:6.89 pituitary:6.43 thyroid/parathyroid:5.98 adrenal gland:6.06 pancreas:7.61 breast:6.45 salivary:7.29
CAGE uterus:1.86 placenta:3.08 prostate:2.12 ovary:2.10 testis:1.58 heart:1.37 muscle:0.79 esophagus:1.81 stomach:- intestine:2.82 colon:2.75     liver/hepato:2.41    lung:2.48 bladder:1.75 kidney:2.18 pituitary:2.14 thyroid/parathyroid:1.67 adrenal gland:- pancreas:2.86 breast:2.59 salivary:3.01
RNA-seq uterus:- placenta:- prostate:3.08 ovary:3.07 testis:2.67 heart:1.12 muscle:0.00 esophagus:- stomach:- intestine:- colon:2.45     liver/hepato:2.98        lung:2.98    bladder:- kidney:2.75 pituitary:- thyroid/parathyroid:2.75 adrenal gland:3.22 pancreas:- breast:1.95 salivary:-

Gene Information

IDs

Refseq ID NM_002560
Gene ID 5025
Unigene ID Hs.321709
Probe set ID 204088_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000135124
GTEx ID ENSG00000135124

Orthologous Gene

Mouse[4]  NM_011026
Rat [0]  

Chromosomal Region

12q24.31  [121,647,660  -  121,671,909]

Gene Family (Interpro ID)

IPR001429  P2X purinoreceptor
IPR003044  P2X1 purinoceptor
IPR003047  P2X4 purinoceptor

Link to Pubmed  (Pubmed ID)

8125298
9016352
9221902
10515189
10899068
10969036
11299224
11606481
12088286
12270951
12477932
12714321
12819199
14978347
15006691
15130891
15167446
15262999
16533808
16949036
17197037
17264311
17785580
17895406
17897319
18487206
18635539
18678988
18852390
19056867
19226284
19283779
19552691
19562525
19913121
19953327
20628086
20660288
20699225
21106936
21768526
21808018
21899776
21988832
22068874
22219189
22528681
22753954
22837036
22988022
22996386
23086000
23138503
23303206
23434541
23936165
23959888

Gene Ontology  (GO ID)

Biological Process

GO:0042118  endothelial cell activation
GO:0051899  membrane depolarization
GO:0010614  negative regulation of cardiac muscle hypertrophy
GO:0051928  positive regulation of calcium ion transport
GO:0010524  positive regulation of calcium ion transport into cytosol
GO:0050850  positive regulation of calcium-mediated signaling
GO:0045429  positive regulation of nitric oxide biosynthetic process
GO:0032308  positive regulation of prostaglandin secretion
GO:0008217  regulation of blood pressure
GO:0055117  regulation of cardiac muscle contraction
GO:0002028  regulation of sodium ion transport
GO:0055119  relaxation of cardiac muscle
GO:0033198  response to ATP
GO:0034405  response to fluid shear stress
GO:0019233  sensory perception of pain
GO:0007165  signal transduction
GO:0001894  tissue homeostasis
GO:0006810  transport

Cellular Component

GO:0030054  cell junction
GO:0005887  integral to plasma membrane
GO:0016020  membrane
GO:0048471  perinuclear region of cytoplasm
GO:0005886  plasma membrane

Molecular Function

GO:0005524  ATP binding
GO:0004931  ATP-gated cation channel activity
GO:0045296  cadherin binding
GO:0005507  copper ion binding
GO:0042803  protein homodimerization activity
GO:0001614  purinergic nucleotide receptor activity
GO:0005102  receptor binding
GO:0008270  zinc ion binding