purinergic receptor P2X, ligand-gated ion channel, 7

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Synonym

P2Z receptor, P2X purinoceptor 7, P2X7, MGC20089, P2RX7

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:93.60 cerebellum:25.20 brain stem:- corpus callosum/glia:379.10 pineal gland:- peripheral nerve:- spine:- retina:- eye:5.90 artery/aorta:- vein:- lymphnode:10.10 peripheral blood:200.40 spleen:189.10 thymus:25.80 bone marrow:19.70 adipose:40.30 bone:230.30 skin:38.40
GeneChip cerebrum:6.55 cerebellum:4.96 brain stem:6.19 corpus callosum/glia:7.87 pineal gland:- peripheral nerve:5.83 spine:6.77 retina:- eye:- artery/aorta:4.70 vein:4.52 lymphnode:5.01 peripheral blood:- spleen:5.34 thymus:4.72 bone marrow:4.54 adipose:4.80 bone:- skin:5.32
CAGE cerebrum:2.96 cerebellum:- brain stem:3.64 corpus callosum/glia:3.97 pineal gland:1.17 peripheral nerve:- spine:3.41 retina:- eye:- artery/aorta:0.59 vein:0.88 lymphnode:1.06 peripheral blood:- spleen:1.02 thymus:0.83 bone marrow:- adipose:1.41 bone:- skin:-
RNA-seq cerebrum:2.36 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:0.00 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0.15 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:45.60 placenta:21.90 prostate:11.30 ovary:- testis:- heart:- muscle:20.10 esophagus:- stomach:21.20 intestine:64.80 colon:-     liver/hepato:10.60        lung:24.40    bladder:125.60 kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:18.60 salivary:-
GeneChip uterus:4.75 placenta:4.42 prostate:4.60 ovary:4.96 testis:4.51 heart:4.35 muscle:4.41 esophagus:4.99 stomach:4.39 intestine:4.62 colon:4.48 liver/hepato:4.84 lung:5.17 bladder:- kidney:4.36 pituitary:4.81 thyroid/parathyroid:4.45 adrenal gland:4.69 pancreas:5.06 breast:5.16 salivary:4.77
CAGE uterus:1.55 placenta:0.54 prostate:1.28 ovary:1.16 testis:0.77 heart:0.28 muscle:0.27 esophagus:0.73 stomach:- intestine:0.53 colon:0.75     liver/hepato:0.90    lung:1.27 bladder:1.24 kidney:0.15 pituitary:0.62 thyroid/parathyroid:0.41 adrenal gland:- pancreas:0.58 breast:0.55 salivary:1.00
RNA-seq uterus:- placenta:- prostate:1.24 ovary:1.12 testis:0.14 heart:0.00 muscle:0.00 esophagus:- stomach:- intestine:- colon:0.59     liver/hepato:0        lung:0.00    bladder:- kidney:0.00 pituitary:- thyroid/parathyroid:0.00 adrenal gland:0.13 pancreas:- breast:0.61 salivary:-

IDs

Refseq ID NM_002562
Gene ID 5027
Unigene ID Hs.507102
Probe set ID 207091_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000089041
GTEx ID ENSG00000089041

Orthologous Gene

Mouse[4]  NM_001038839, NM_001038845, NM_001038887, NM_011027
Rat [0]  

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed  (Pubmed ID)

8125298
9038151
9826911
11150303
11341329
11707406
11852049
11943260
12107182
12270951
12404161
12422208
12456589
12477932
12493261
12586825
12633871
12759456
12787128
12874219
12874700
12880424
12931211
14510944
14607949
14702039
14976257
15004138
15089763
15120006
15123679
15155383
15184265
15304508
15472991
15475073
15489334
15571247
15728711
15777864
15778408
15830104
15862308
15896293
15899033
15901833
15923180
15942904
15972634
15991050
16117789
16228288
16263709
16321858
16344560
16424024
16514055
16541075
16624800
16673375
16740600
16822851
17032903
17036048
17040997
17065062
17065105
17095747
17130901
17142754
17197037
17257221
17286963
17314141
17474147
17482244
17483156
17488689
17558311
17785580
17895406
17928361
17947359
18040764
18071294
18089587
18211888
18268501
18436590
18523309
18543274
18545980
18596211
18614336
18617511
18676680
18678419
18682393
18765670
18801407
18852390
18937793
18971257
18987356
19017759
19068080
19074885
19076224
19151591
19160446
19170196
19186133
19201928
19204004
19211924
19225709
19226284
19264037
19309360
19328558
19330776
19396427
19430700
19453261
19494237
19548263
19552691
19625176
19682070
19692168
19700502
19748989
19882109
19889958
19891999
19913121
19931869
20007545
20138022
20164546
20185692
20188863
20196868
20226536
20351714
20360457
20378545
20379614
20424473
20446288
20450227
20453110
20488797
20493226
20495003
20508067
20535134
20605778
20628086
20661107
20668222
20813842
20819262
20837475
20846359
21041608
21187936
21205829
21233486
21262970
21266468
21335057
21438144
21470339
21492831
21508263
21565445
21635566
21640086
21645266
21651910
21670495
21697458
21821797
21865551
21911484
21941410
21978920
21988719
21988832
22017219
22048123
22134903
22137490
22163032
22183411
22234152
22250198
22274585
22295949
22377955
22447075
22450808
22461619
22476940
22490780
22493010
22505653
22547202
22613720
22623165
22662160
22703695
22707062
22743305
22768094
22776862
22806078
22891241
22898868
22906303
22946048
22948816
22952630
22996386
23047057
23050672
23095809
23144325
23144326
23204228
23210974
23250993
23293841
23303206
23319734
23404811
23408402
23428418
23435013
23479230
23524196
23602648
23648388
23691096
23843215
23936165
23947898
24013409
24220590
24487066

Gene Ontology  (GO ID)

Biological Process

GO:0000187  activation of MAPK activity
GO:0032060  bleb formation
GO:0000902  cell morphogenesis
GO:0007166  cell surface receptor linked signal transduction
GO:0006884  cell volume homeostasis
GO:0031668  cellular response to extracellular stimulus
GO:0046513  ceramide biosynthetic process
GO:0032963  collagen metabolic process
GO:0019835  cytolysis
GO:0050830  defense response to Gram-positive bacterium
GO:0048873  homeostasis of number of cells within a tissue
GO:0006954  inflammatory response
GO:0045087  innate immune response
GO:0006900  membrane budding
GO:0051899  membrane depolarization
GO:0006509  membrane protein ectodomain proteolysis
GO:0007005  mitochondrion organization
GO:0044254  multicellular organismal protein catabolic process
GO:0043132  NAD transport
GO:0045779  negative regulation of bone resorption
GO:0043409  negative regulation of MAPKKK cascade
GO:0001845  phagolysosome formation
GO:0006649  phospholipid transfer to membrane
GO:0045332  phospholipid translocation
GO:0007009  plasma membrane organization
GO:0046931  pore complex assembly
GO:0043065  positive regulation of apoptosis
GO:0030501  positive regulation of bone mineralization
GO:0010524  positive regulation of calcium ion transport into cytosol
GO:0045919  positive regulation of cytolysis
GO:0051495  positive regulation of cytoskeleton organization
GO:0014054  positive regulation of gamma-aminobutyric acid secretion
GO:0014049  positive regulation of glutamate secretion
GO:0050717  positive regulation of interleukin-1 alpha secretion
GO:0050718  positive regulation of interleukin-1 beta secretion
GO:0032755  positive regulation of interleukin-6 production
GO:0051901  positive regulation of mitochondrial depolarization
GO:0032308  positive regulation of prostaglandin secretion
GO:0001916  positive regulation of T cell mediated cytotoxicity
GO:0006468  protein amino acid phosphorylation
GO:0051259  protein oligomerization
GO:0016485  protein processing
GO:0019228  regulation of action potential in neuron
GO:0051709  regulation of killing of cells of another organism
GO:0002028  regulation of sodium ion transport
GO:0051209  release of sequestered calcium ion into cytosol
GO:0033198  response to ATP
GO:0051592  response to calcium ion
GO:0042493  response to drug
GO:0051602  response to electrical stimulus
GO:0034405  response to fluid shear stress
GO:0032496  response to lipopolysaccharide
GO:0009612  response to mechanical stimulus
GO:0010043  response to zinc ion
GO:0019233  sensory perception of pain
GO:0048705  skeletal system morphogenesis
GO:0016079  synaptic vesicle exocytosis
GO:0043029  T cell homeostasis
GO:0042098  T cell proliferation

Cellular Component

GO:0032059  bleb
GO:0043025  cell soma
GO:0005911  cell-cell junction
GO:0005737  cytoplasm
GO:0009897  external side of plasma membrane
GO:0005639  integral to nuclear inner membrane
GO:0005887  integral to plasma membrane
GO:0016020  membrane
GO:0045121  membrane raft
GO:0031594  neuromuscular junction
GO:0005886  plasma membrane
GO:0043234  protein complex
GO:0043195  terminal button

Molecular Function

GO:0005524  ATP binding
GO:0004931  ATP-gated cation channel activity
GO:0005507  copper ion binding
GO:0001530  lipopolysaccharide binding
GO:0000287  magnesium ion binding
GO:0042803  protein homodimerization activity
GO:0001614  purinergic nucleotide receptor activity
GO:0005102  receptor binding
GO:0008270  zinc ion binding