platelet-activating factor acetylhydrolase, isoform Ib, subunit 1 (45kDa)

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Synonym

LIS2, PAFAHA, PAFAH alpha, Lissencephaly-1 protein, PAFAH, PAFAH1B1, LIS-1, LIS1, PAF-AH 45 kDa subunit, PAF-AH alpha, PAF acetylhydrolase 45 kDa subunit

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:379.20 cerebellum:415.60 brain stem:- corpus callosum/glia:87.50 pineal gland:296.70 peripheral nerve:184 spine:336.90 retina:118.60 eye:217.40 artery/aorta:119.90 vein:133.30 lymphnode:80.90 peripheral blood:109.30 spleen:113.40 thymus:309.20 bone marrow:78.70 adipose:80.70 bone:76.80 skin:177.60
GeneChip cerebrum:9.28 cerebellum:9.54 brain stem:9.29 corpus callosum/glia:8.67 pineal gland:- peripheral nerve:9.38 spine:8.78 retina:- eye:- artery/aorta:8.02 vein:7.90 lymphnode:7.87 peripheral blood:- spleen:7.98 thymus:8.50 bone marrow:7.08 adipose:8.02 bone:- skin:8.29
CAGE cerebrum:4.77 cerebellum:- brain stem:4.78 corpus callosum/glia:4.44 pineal gland:4.55 peripheral nerve:- spine:4.36 retina:- eye:- artery/aorta:4.03 vein:3.87 lymphnode:3.74 peripheral blood:- spleen:3.81 thymus:4.35 bone marrow:- adipose:3.90 bone:- skin:-
RNA-seq cerebrum:6.23 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:4.42 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:4.53 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:200.50 placenta:116.60 prostate:169 ovary:149.10 testis:203.30 heart:102.20 muscle:40.20 esophagus:- stomach:106.20 intestine:64.80 colon:144.20     liver/hepato:73.90        lung:195.50    bladder:125.60 kidney:93.60 pituitary:232 thyroid/parathyroid:- adrenal gland:- pancreas:44.50 breast:102.20 salivary:656.80
GeneChip uterus:8.46 placenta:7.96 prostate:8.37 ovary:8.45 testis:7.43 heart:7.98 muscle:8.83 esophagus:8.10 stomach:7.89 intestine:7.91 colon:7.12 liver/hepato:7.28 lung:8.16 bladder:- kidney:7.77 pituitary:8.58 thyroid/parathyroid:8.39 adrenal gland:7.88 pancreas:6.43 breast:8.24 salivary:7.52
CAGE uterus:4.12 placenta:3.96 prostate:3.93 ovary:4.04 testis:4.39 heart:4.20 muscle:4.82 esophagus:4.06 stomach:- intestine:4.26 colon:3.99     liver/hepato:3.75    lung:4.23 bladder:4.15 kidney:3.91 pituitary:4.36 thyroid/parathyroid:4.02 adrenal gland:- pancreas:3.52 breast:3.52 salivary:3.73
RNA-seq uterus:- placenta:- prostate:4.88 ovary:5.30 testis:5.39 heart:5.02 muscle:5.21 esophagus:- stomach:- intestine:- colon:4.82     liver/hepato:3.48        lung:4.31    bladder:- kidney:4.92 pituitary:- thyroid/parathyroid:5.78 adrenal gland:4.73 pancreas:- breast:4.92 salivary:-

Gene Information

IDs

Refseq ID NM_000430
Gene ID 5048
Unigene ID Hs.77318
Probe set ID 200816_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000007168
GTEx ID ENSG00000007168

Orthologous Gene

Mouse[3]  NM_013625
Rat [0]  

Chromosomal Region

17p13.3  [2,496,923  -  2,588,909]

Gene Family (Interpro ID)

IPR020472  G-protein beta WD-40 repeat, region
IPR006594  LisH dimerisation motif
IPR001680  WD40 repeat
IPR019782  WD40 repeat 2
IPR019781  WD40 repeat, subgroup
IPR011046  WD40 repeat-like-containing domain
IPR017986  WD40-repeat-containing domain
IPR015943  WD40/YVTN repeat-like-containing domain

Link to Pubmed  (Pubmed ID)

7573359
7790358
8028668
8355785
8586424
9044400
9063735
9131135
9218411
9384577
9601647
9626899
10441340
10491172
10727864
10729324
10931877
11001923
11056532
11076968
11163258
11163260
11294621
11502906
11734602
11754098
11803439
11889140
11916011
11940666
12110797
12185771
12221128
12477932
12496397
12556484
12796778
12852856
12885786
14578885
14581661
14584027
14733918
14962739
14970193
15007136
15057976
15081260
15173193
15489334
15698475
15762842
16009940
16027700
16086290
16138011
16144905
16169070
16203747
16258276
16411107
16462731
16549273
16642511
16689754
16761416
16766276
16806233
17018134
17041588
17043677
17664403
17850624
18029348
18285425
18421979
18431085
18524253
18781797
18784752
18818748
19019335
19020519
19050731
19056867
19136950
19251251
19527514
19622634
19632097
19667223
19913121
20048338
20084519
20133715
20140262
20168084
20301752
20360068
20452482
20452996
20464283
20628086
20634891
20673868
20675372
21036906
21092859
21107783
21139048
21319273
21565611
21569763
21593204
21652625
21890215
21906983
21911489
22006948
22328561
22373868
22505724
22749159
22863883
22956769
23813913
24487275
24654937

Gene Ontology  (GO ID)

Biological Process

GO:0001675  acrosome assembly
GO:0030036  actin cytoskeleton organization
GO:0008344  adult locomotory behavior
GO:0001667  ameboidal cell migration
GO:0048854  brain morphogenesis
GO:0021987  cerebral cortex development
GO:0021895  cerebral cortex neuron differentiation
GO:0021540  corpus callosum morphogenesis
GO:0051660  establishment of centrosome localization
GO:0000132  establishment of mitotic spindle orientation
GO:0000086  G2/M transition of mitotic cell cycle
GO:0021766  hippocampus development
GO:0021819  layer formation in the cerebral cortex
GO:0007611  learning or memory
GO:0016042  lipid catabolic process
GO:0000226  microtubule cytoskeleton organization
GO:0031023  microtubule organizing center organization
GO:0007017  microtubule-based process
GO:0007067  mitosis
GO:0000278  mitotic cell cycle
GO:0046329  negative regulation of JNK cascade
GO:0010977  negative regulation of neuron projection development
GO:0007405  neuroblast proliferation
GO:0050885  neuromuscular process controlling balance
GO:0001764  neuron migration
GO:0051081  nuclear envelope disassembly
GO:0007097  nuclear migration
GO:0046469  platelet activating factor metabolic process
GO:0045773  positive regulation of axon extension
GO:0001961  positive regulation of cytokine-mediated signaling pathway
GO:0045931  positive regulation of mitotic cell cycle
GO:0009306  protein secretion
GO:0032319  regulation of Rho GTPase activity
GO:0008090  retrograde axon cargo transport
GO:0017145  stem cell division
GO:0007268  synaptic transmission
GO:0019226  transmission of nerve impulse
GO:0047496  vesicle transport along microtubule

Cellular Component

GO:0000235  astral microtubule
GO:0005938  cell cortex
GO:0031252  cell leading edge
GO:0043025  cell soma
GO:0005813  centrosome
GO:0005737  cytoplasm
GO:0005829  cytosol
GO:0030426  growth cone
GO:0005871  kinesin complex
GO:0000776  kinetochore
GO:0005875  microtubule associated complex
GO:0031512  motile primary cilium
GO:0031513  nonmotile primary cilium
GO:0005635  nuclear envelope
GO:0031965  nuclear membrane
GO:0005730  nucleolus
GO:0005634  nucleus
GO:0048471  perinuclear region of cytoplasm
GO:0031982  vesicle

Molecular Function

GO:0034452  dynactin binding
GO:0045502  dynein binding
GO:0045505  dynein intermediate chain binding
GO:0008201  heparin binding
GO:0008017  microtubule binding
GO:0043274  phospholipase binding
GO:0051219  phosphoprotein binding
GO:0005515  protein binding
GO:0032403  protein complex binding
GO:0042803  protein homodimerization activity