misshapen-like kinase 1 (zebrafish)

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Synonym

hMINK, YSK2, ZC3, MGC21111, MAPK/ERK kinase kinase kinase 6, MEKKK 6, MINK, MEK kinase kinase 6, misshapen-like kinase 1 (zebrafish), MAP4K6, B55, GCK family kinase MiNK, hMINKbeta, Misshapen/NIK-related kinase, MINK1, Misshapen-like kinase 1

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:52.10 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:30.70 spine:224.60 retina:- eye:146.90 artery/aorta:- vein:- lymphnode:50.60 peripheral blood:36.40 spleen:75.60 thymus:51.50 bone marrow:59 adipose:- bone:12.80 skin:72
GeneChip cerebrum:8.29 cerebellum:8.02 brain stem:7.73 corpus callosum/glia:8.85 pineal gland:- peripheral nerve:8.05 spine:8.90 retina:- eye:- artery/aorta:7.63 vein:6.62 lymphnode:8.43 peripheral blood:- spleen:8.31 thymus:7.52 bone marrow:7.56 adipose:7.60 bone:- skin:8.48
CAGE cerebrum:4.71 cerebellum:- brain stem:4.77 corpus callosum/glia:4.88 pineal gland:3.61 peripheral nerve:- spine:4.49 retina:- eye:- artery/aorta:3.46 vein:3.64 lymphnode:3.68 peripheral blood:- spleen:3.47 thymus:3.46 bone marrow:- adipose:3.56 bone:- skin:-
RNA-seq cerebrum:0.70 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:0.67 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0.61 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:54.70 placenta:80.10 prostate:11.30 ovary:149.10 testis:34.60 heart:12.80 muscle:- esophagus:- stomach:85 intestine:32.40 colon:195     liver/hepato:10.60        lung:44    bladder:- kidney:31.20 pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:62.20 breast:55.80 salivary:-
GeneChip uterus:7.28 placenta:7.93 prostate:7.35 ovary:7.53 testis:7.94 heart:6.74 muscle:5.52 esophagus:8.80 stomach:7.79 intestine:7.37 colon:7.86 liver/hepato:7.34 lung:8.31 bladder:- kidney:7.79 pituitary:8.08 thyroid/parathyroid:7.97 adrenal gland:8.25 pancreas:7.03 breast:8.42 salivary:7.72
CAGE uterus:3.91 placenta:3.88 prostate:3.59 ovary:4.02 testis:3.99 heart:3.22 muscle:2.96 esophagus:4.19 stomach:- intestine:4.22 colon:4.10     liver/hepato:2.92    lung:3.58 bladder:3.43 kidney:3.58 pituitary:4.01 thyroid/parathyroid:3.28 adrenal gland:- pancreas:3.77 breast:2.87 salivary:4.01
RNA-seq uterus:- placenta:- prostate:1.01 ovary:2.46 testis:1.07 heart:0.38 muscle:0.00 esophagus:- stomach:- intestine:- colon:1.32     liver/hepato:0.97        lung:0.43    bladder:- kidney:1.95 pituitary:- thyroid/parathyroid:1.41 adrenal gland:1.23 pancreas:- breast:1.87 salivary:-

Gene Information

IDs

Refseq ID NM_001024937
Gene ID 50488
Unigene ID Hs.443417
Probe set ID 214246_x_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000141503
GTEx ID ENSG00000141503

Orthologous Gene

Mouse[4]  NM_001045959, NM_001045964, NM_016713, NM_176893
Rat[4]  NM_001045959, NM_001045964, NM_016713, NM_176893

Chromosomal Region

17p13.2  [4,736,635  -  4,801,355]

Gene Family (Interpro ID)

IPR000719  Protein kinase, catalytic domain
IPR011009  Protein kinase-like domain
IPR002290  Serine/threonine-protein kinase domain
IPR017442  Serine/threonine-protein kinase-like domain
IPR001245  Tyrosine-protein kinase, catalytic domain
IPR020635  Tyrosine-protein kinase, subgroup, catalytic domain

Link to Pubmed  (Pubmed ID)

8889548
10708748
12087176
12107410
12477932
12665801
12668260
14702039
15032605
15302935
15469942
15489334
16344560
16760206
17081983
17165161
18752142
18930710
19056867
19953087
21048137
21890473
21906983
21963094
22037766
22665485
22939624
23000965
24250222

Gene Ontology  (GO ID)

Biological Process

GO:0031532  actin cytoskeleton reorganization
GO:0048813  dendrite morphogenesis
GO:0007254  JNK cascade
GO:0007275  multicellular organismal development
GO:0045060  negative thymic T cell selection
GO:0046330  positive regulation of JNK cascade
GO:0046777  protein amino acid autophosphorylation
GO:0006468  protein amino acid phosphorylation
GO:0007243  protein kinase cascade
GO:0030334  regulation of cell migration
GO:0022407  regulation of cell-cell adhesion
GO:0001952  regulation of cell-matrix adhesion
GO:0006950  response to stress
GO:0007268  synaptic transmission

Cellular Component

GO:0030424  axon
GO:0030054  cell junction
GO:0005737  cytoplasm
GO:0030425  dendrite
GO:0005794  Golgi apparatus
GO:0005886  plasma membrane
GO:0014069  postsynaptic density
GO:0045211  postsynaptic membrane

Molecular Function

GO:0005524  ATP binding
GO:0005515  protein binding
GO:0004672  protein kinase activity
GO:0004674  protein serine/threonine kinase activity
GO:0005083  small GTPase regulator activity