NADPH oxidase 4

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Synonym

NADPH oxidase 4, Kidney superoxide-producing NADPH oxidase, KOX, NOX4, KOX-1, Renal NAD(P)H-oxidase, RENOX

normal 40 tissues
cell lines, primary cells, adult tissues and fetal tissues (FANTOM5 CAGE)

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain

blood

connective

EST

cerebrum:7.10

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:237.30

eye:11.80

artery/aorta:60

vein:-

lymphnode:-

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:-

bone:38.40

skin:33.60

GeneChip

cerebrum:2.98

cerebellum:2.98

brain stem:3.01

corpus callosum/glia:3.03

pineal gland:-

peripheral nerve:3.60

spine:3.12

retina:-

eye:-

artery/aorta:5.28

vein:5.02

lymphnode:2.91

peripheral blood:-

spleen:2.84

thymus:3.07

bone marrow:3.07

adipose:3.58

bone:-

skin:3.71

CAGE

cerebrum:0.36

cerebellum:-

brain stem:0.24

corpus callosum/glia:0.99

pineal gland:0.35

peripheral nerve:-

spine:0.89

retina:-

eye:-

artery/aorta:4.07

vein:1.76

lymphnode:0.41

peripheral blood:-

spleen:0.56

thymus:0.18

bone marrow:-

adipose:2.46

bone:-

skin:-

RNA-seq

cerebrum:0.00

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:1.10

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:0.00

bone:-

skin:-

reproductive

muscular

alimentary

liver

lung

urinary

endo/exo-crine

EST

uterus:36.50

placenta:3.60

prostate:-

ovary:37.30

testis:-

heart:-

muscle:-

esophagus:-

stomach:21.20

intestine:32.40

colon:8.50

liver/hepato:31.70

lung:-

bladder:-

kidney:280.70

pituitary:-

thyroid/parathyroid:-

adrenal gland:-

pancreas:-

breast:18.60

salivary:-

GeneChip

uterus:3.75

placenta:3.58

prostate:3.13

ovary:3.17

testis:2.87

heart:4.38

muscle:3.42

esophagus:3.07

stomach:3.03

intestine:3.37

colon:3.08

liver/hepato:2.92

lung:3.09

bladder:-

kidney:7

pituitary:3.04

thyroid/parathyroid:3.28

adrenal gland:2.97

pancreas:3.23

breast:3.35

salivary:2.92

CAGE

uterus:1.80

placenta:1.11

prostate:1.58

ovary:0.76

testis:0.73

heart:2.42

muscle:2.05

esophagus:1.26

stomach:-

intestine:0.27

colon:0.73

liver/hepato:0.14

lung:1.08

bladder:1.52

kidney:4.28

pituitary:0.50

thyroid/parathyroid:1.23

adrenal gland:-

pancreas:0.94

breast:2.53

salivary:0.62

RNA-seq

uterus:-

placenta:-

prostate:0.52

ovary:0.00

testis:0

heart:0.14

muscle:0

esophagus:-

stomach:-

intestine:-

colon:0

liver/hepato:0.08

lung:0.00

bladder:-

kidney:0.26

pituitary:-

thyroid/parathyroid:0

adrenal gland:0

pancreas:-

breast:0.00

salivary:-

IDs

Refseq ID	NM_001143836
Gene ID	50507
Unigene ID	Hs.371036
Probe set ID	219773_at [HG-U133_Plus_2]
Ensembl ID	ENSG00000086991
GTEx ID	ENSG00000086991

Orthologous Gene

Mouse[2]	NM_015760
Rat [0]

Chromosomal Region

11q14.3 [89,057,524 - 89,322,779]

Search genes near this gene
- Between -5kb and +5kb
- Between -10kb and +10kb

Gene Family (Interpro ID)

Gene Ontology (GO ID)

Biological Process

GO:0045453	bone resorption
GO:0035051	cardiac cell differentiation
GO:0007569	cell aging
GO:0000902	cell morphogenesis
GO:0071320	cellular response to cAMP
GO:0071480	cellular response to gamma radiation
GO:0071333	cellular response to glucose stimulus
GO:0050667	homocysteine metabolic process
GO:0006954	inflammatory response
GO:0008285	negative regulation of cell proliferation
GO:0055114	oxidation reduction
GO:0043065	positive regulation of apoptosis
GO:0070374	positive regulation of ERK1 and ERK2 cascade
GO:0043406	positive regulation of MAP kinase activity
GO:0051897	positive regulation of protein kinase B signaling cascade
GO:0014911	positive regulation of smooth muscle cell migration
GO:0051496	positive regulation of stress fiber formation
GO:0001666	response to hypoxia
GO:0042554	superoxide anion generation

Cellular Component

GO:0016324	apical plasma membrane
GO:0005789	endoplasmic reticulum membrane
GO:0005925	focal adhesion
GO:0016021	integral to membrane
GO:0005739	mitochondrion
GO:0043020	NADPH oxidase complex
GO:0005634	nucleus
GO:0048471	perinuclear region of cytoplasm

Molecular Function

GO:0009055	electron carrier activity
GO:0050660	FAD binding
GO:0020037	heme binding
GO:0016174	NAD(P)H oxidase activity
GO:0000166	nucleotide binding
GO:0019826	oxygen sensor activity
GO:0016175	superoxide-generating NADPH oxidase activity

NADPH oxidase 4

Synonym

Expression Pattern

Choropleth map on BodyParts3D

Classification in 40 Organs

Gene Information

IDs

Orthologous Gene

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

Cellular Component

Molecular Function