p21 protein (Cdc42/Rac)-activated kinase 1

Synonym

PAK-1, MGC130001, PAKalpha, Alpha-PAK, MGC130000, PAK1, Serine/threonine-protein kinase PAK 1, P65-PAK, p21-activated kinase 1

normal 40 tissues
cell lines, primary cells, adult tissues and fetal tissues (FANTOM5 CAGE)

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain

blood

connective

EST

cerebrum:77

cerebellum:138.50

brain stem:-

corpus callosum/glia:58.30

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:35.30

artery/aorta:60

vein:-

lymphnode:-

peripheral blood:36.40

spleen:18.90

thymus:77.30

bone marrow:177.10

adipose:40.30

bone:25.60

skin:211.20

GeneChip

cerebrum:4.29

cerebellum:4.37

brain stem:4.12

corpus callosum/glia:3.26

pineal gland:-

peripheral nerve:3.47

spine:3.23

retina:-

eye:-

artery/aorta:3.35

vein:3.19

lymphnode:3.43

peripheral blood:-

spleen:3.15

thymus:3.58

bone marrow:4.77

adipose:3.38

bone:-

skin:3.51

CAGE

cerebrum:5.01

cerebellum:-

brain stem:4.35

corpus callosum/glia:4.01

pineal gland:3.30

peripheral nerve:-

spine:3.79

retina:-

eye:-

artery/aorta:3.48

vein:3.58

lymphnode:3.67

peripheral blood:-

spleen:3.77

thymus:3.70

bone marrow:-

adipose:3.52

bone:-

skin:-

RNA-seq

cerebrum:5.91

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:2.94

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:2.23

bone:-

skin:-

reproductive

muscular

alimentary

liver

lung

urinary

endo/exo-crine

EST

uterus:91.10

placenta:69.20

prostate:90.10

ovary:-

testis:17.30

heart:25.50

muscle:40.20

esophagus:-

stomach:-

intestine:64.80

colon:178.10

liver/hepato:31.70

lung:14.70

bladder:-

kidney:41.60

pituitary:116

thyroid/parathyroid:163.70

adrenal gland:-

pancreas:62.20

breast:213.70

salivary:-

GeneChip

uterus:3.72

placenta:3.63

prostate:3.81

ovary:3.67

testis:4.38

heart:3.20

muscle:3.69

esophagus:3.60

stomach:3.53

intestine:3.84

colon:3.91

liver/hepato:3.22

lung:3.45

bladder:-

kidney:3.46

pituitary:3.53

thyroid/parathyroid:3.57

adrenal gland:3.17

pancreas:3.59

breast:3.31

salivary:3.47

CAGE

uterus:3.87

placenta:4.18

prostate:4.38

ovary:3.69

testis:3.51

heart:2.90

muscle:4.00

esophagus:3.52

stomach:-

intestine:4.25

colon:3.96

liver/hepato:2.65

lung:3.51

bladder:3.95

kidney:3.46

pituitary:4.03

thyroid/parathyroid:3.57

adrenal gland:-

pancreas:3.34

breast:3.12

salivary:3.58

RNA-seq

uterus:-

placenta:-

prostate:4.19

ovary:4.02

testis:3.93

heart:1.94

muscle:3.21

esophagus:-

stomach:-

intestine:-

colon:3.73

liver/hepato:1.66

lung:3.18

bladder:-

kidney:3.52

pituitary:-

thyroid/parathyroid:4.31

adrenal gland:2.39

pancreas:-

breast:3.08

salivary:-

IDs

Refseq ID	NM_002576
Gene ID	5058
Unigene ID	Hs.435714
Probe set ID	209615_s_at [HG-U133_Plus_2]
Ensembl ID	ENSG00000149269
GTEx ID	ENSG00000149269

Orthologous Gene

Mouse[3]	NM_011035
Rat [0]

Chromosomal Region

11q14.1 [77,032,752 - 77,185,680]

Search genes near this gene
- Between -5kb and +5kb
- Between -10kb and +10kb

Gene Family (Interpro ID)

IPR000719	Protein kinase, catalytic domain
IPR011009	Protein kinase-like domain
IPR002290	Serine/threonine-protein kinase domain
IPR017442	Serine/threonine-protein kinase-like domain
IPR001245	Tyrosine-protein kinase, catalytic domain
IPR020635	Tyrosine-protein kinase, subgroup, catalytic domain

Gene Ontology (GO ID)

Biological Process

GO:0031532	actin cytoskeleton reorganization
GO:0006915	apoptosis
GO:0007411	axon guidance
GO:0048754	branching morphogenesis of a tube
GO:0032869	cellular response to insulin stimulus
GO:0033554	cellular response to stress
GO:0016358	dendrite development
GO:0006887	exocytosis
GO:0045087	innate immune response
GO:0000165	MAPKKK cascade
GO:0060244	negative regulation of cell proliferation involved in contact inhibition
GO:0007528	neuromuscular junction development
GO:0048812	neuron projection morphogenesis
GO:0033148	positive regulation of estrogen receptor signaling pathway
GO:0043507	positive regulation of JUN kinase activity
GO:0033138	positive regulation of peptidyl-serine phosphorylation
GO:0051496	positive regulation of stress fiber formation
GO:0046777	protein amino acid autophosphorylation
GO:0006468	protein amino acid phosphorylation
GO:0043113	receptor clustering
GO:0001666	response to hypoxia
GO:0031295	T cell costimulation
GO:0050852	T cell receptor signaling pathway
GO:0042060	wound healing

Cellular Component

GO:0030424	axon
GO:0005911	cell-cell junction
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0030425	dendrite
GO:0031941	filamentous actin
GO:0005925	focal adhesion
GO:0005794	Golgi apparatus
GO:0030426	growth cone
GO:0014704	intercalated disc
GO:0031965	nuclear membrane
GO:0005886	plasma membrane
GO:0043234	protein complex
GO:0001726	ruffle
GO:0030018	Z disc

Molecular Function

GO:0005524	ATP binding
GO:0005518	collagen binding
GO:0042802	identical protein binding
GO:0005515	protein binding
GO:0004672	protein kinase activity
GO:0019901	protein kinase binding
GO:0004674	protein serine/threonine kinase activity

p21 protein (Cdc42/Rac)-activated kinase 1

Synonym

Expression Pattern

Choropleth map on BodyParts3D

Classification in 40 Organs

Gene Information

IDs

Orthologous Gene

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

Cellular Component

Molecular Function