peptidylglycine alpha-amidating monooxygenase

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Synonym

PAM, peptidylglycine alpha-amidating monooxygenase, PHM, PAL

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:327.10 cerebellum:289.70 brain stem:- corpus callosum/glia:145.80 pineal gland:296.70 peripheral nerve:368.10 spine:336.90 retina:118.60 eye:70.50 artery/aorta:179.90 vein:66.60 lymphnode:10.10 peripheral blood:36.40 spleen:189.10 thymus:64.40 bone marrow:- adipose:121 bone:371.10 skin:225.60
GeneChip cerebrum:7.11 cerebellum:6.55 brain stem:7.23 corpus callosum/glia:6.26 pineal gland:- peripheral nerve:7.46 spine:6.88 retina:- eye:- artery/aorta:8.06 vein:8.45 lymphnode:6.56 peripheral blood:- spleen:6.87 thymus:5.20 bone marrow:6.04 adipose:7.21 bone:- skin:6.85
CAGE cerebrum:4.11 cerebellum:- brain stem:3.78 corpus callosum/glia:3.54 pineal gland:5.05 peripheral nerve:- spine:3.67 retina:- eye:- artery/aorta:5.86 vein:4.43 lymphnode:3.66 peripheral blood:- spleen:4.00 thymus:2.35 bone marrow:- adipose:4.63 bone:- skin:-
RNA-seq cerebrum:2.79 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:1.51 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:3.23 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:574.10 placenta:284.20 prostate:123.90 ovary:37.30 testis:64.90 heart:344.80 muscle:120.50 esophagus:- stomach:361.10 intestine:129.60 colon:50.90     liver/hepato:84.40        lung:523    bladder:- kidney:124.80 pituitary:232 thyroid/parathyroid:163.70 adrenal gland:253.90 pancreas:586.80 breast:148.70 salivary:-
GeneChip uterus:8.15 placenta:8 prostate:7.19 ovary:7.59 testis:5.72 heart:8.96 muscle:7.46 esophagus:6.87 stomach:7.46 intestine:7.37 colon:7.11 liver/hepato:6.30 lung:7.13 bladder:- kidney:7.29 pituitary:7.89 thyroid/parathyroid:7.39 adrenal gland:7.95 pancreas:7.41 breast:7.03 salivary:8.96
CAGE uterus:5.14 placenta:4.98 prostate:4.48 ovary:4.51 testis:3.71 heart:6.53 muscle:4.71 esophagus:4.26 stomach:- intestine:3.98 colon:4.35     liver/hepato:2.28    lung:4.52 bladder:4.58 kidney:4.40 pituitary:5.14 thyroid/parathyroid:4.81 adrenal gland:- pancreas:4.58 breast:4.70 salivary:5.90
RNA-seq uterus:- placenta:- prostate:3.86 ovary:3.54 testis:3.33 heart:5.88 muscle:4.02 esophagus:- stomach:- intestine:- colon:4.23     liver/hepato:1.03        lung:3.89    bladder:- kidney:1.72 pituitary:- thyroid/parathyroid:2.40 adrenal gland:2.69 pancreas:- breast:3.43 salivary:-

Gene Information

IDs

Refseq ID NM_000919
Gene ID 5066
Unigene ID Hs.369430
Probe set ID 214620_x_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000145730
GTEx ID ENSG00000145730

Orthologous Gene

Mouse[2]  NM_013626
Rat [0]  

Chromosomal Region

5q21.1  [102,089,685  -  102,366,809]

Gene Family (Interpro ID)

IPR001258  NHL repeat
IPR013017  NHL repeat, subgroup

Link to Pubmed  (Pubmed ID)

1448112
2357221
7590286
7606087
7760848
7999037
8094086
8102327
8144680
8288234
8486658
8518727
8530412
8543779
8619474
9110174
9139723
9562574
9837933
10574929
11668475
12364573
12477932
12699694
14559897
15489334
15840729
16107699
16344560
17081983
19199708
19571808
19693765
19946888
20351714
20379614
20534529
21890473
21906983
22080626
22554821
23000965
24464100

Gene Ontology  (GO ID)

Biological Process

GO:0007417  central nervous system development
GO:0007507  heart development
GO:0060173  limb development
GO:0001676  long-chain fatty acid metabolic process
GO:0060135  maternal process involved in female pregnancy
GO:0042476  odontogenesis
GO:0022602  ovulation cycle process
GO:0001519  peptide amidation
GO:0006518  peptide metabolic process
GO:0018032  protein amino acid amidation
GO:0051260  protein homooligomerization
GO:0006464  protein modification process
GO:0032956  regulation of actin cytoskeleton organization
GO:0050708  regulation of protein secretion
GO:0006357  regulation of transcription from RNA polymerase II promoter
GO:0046688  response to copper ion
GO:0042493  response to drug
GO:0032355  response to estradiol stimulus
GO:0051384  response to glucocorticoid stimulus
GO:0001666  response to hypoxia
GO:0009268  response to pH
GO:0009404  toxin metabolic process

Cellular Component

GO:0009986  cell surface
GO:0005576  extracellular region
GO:0016021  integral to membrane
GO:0043005  neuron projection
GO:0043204  perikaryon
GO:0048471  perinuclear region of cytoplasm
GO:0005886  plasma membrane
GO:0030141  secretory granule
GO:0030667  secretory granule membrane
GO:0005802  trans-Golgi network

Molecular Function

GO:0005509  calcium ion binding
GO:0005507  copper ion binding
GO:0031418  L-ascorbic acid binding
GO:0004598  peptidylamidoglycolate lyase activity
GO:0004504  peptidylglycine monooxygenase activity
GO:0005515  protein binding
GO:0019901  protein kinase binding
GO:0008270  zinc ion binding