lymphoid enhancer-binding factor 1

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Synonym

LEF1, LEF-1, lymphoid enhancer-binding factor 1, TCF1ALPHA, TCF1-alpha, T cell-specific transcription factor 1-alpha, Lymphoid enhancer-binding factor 1, DKFZp586H0919

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST nodata
GeneChip cerebrum:6.44 cerebellum:5.45 brain stem:6.36 corpus callosum/glia:6.07 pineal gland:- peripheral nerve:7.28 spine:6.36 retina:- eye:- artery/aorta:5.11 vein:5.31 lymphnode:9.06 peripheral blood:- spleen:7.88 thymus:12.16 bone marrow:7.26 adipose:5.83 bone:- skin:6.20
CAGE cerebrum:1.85 cerebellum:- brain stem:2.14 corpus callosum/glia:2.35 pineal gland:2.00 peripheral nerve:- spine:1.88 retina:- eye:- artery/aorta:1.57 vein:4.83 lymphnode:4.18 peripheral blood:- spleen:2.83 thymus:6.71 bone marrow:- adipose:1.21 bone:- skin:-
RNA-seq cerebrum:0.13 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:1.32 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0.00 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST nodata
GeneChip uterus:7.38 placenta:5.91 prostate:6.42 ovary:6.37 testis:8.02 heart:4.90 muscle:4.88 esophagus:5.56 stomach:5.60 intestine:5.59 colon:5.74 liver/hepato:5.12 lung:6.07 bladder:- kidney:5.76 pituitary:5.32 thyroid/parathyroid:6.31 adrenal gland:8.46 pancreas:4.39 breast:6.52 salivary:4.82
CAGE uterus:2.52 placenta:1.86 prostate:1.91 ovary:1.87 testis:2.95 heart:0.70 muscle:0.49 esophagus:2.01 stomach:- intestine:1.52 colon:1.21     liver/hepato:0    lung:2.19 bladder:1.76 kidney:1.86 pituitary:1.11 thyroid/parathyroid:2.16 adrenal gland:- pancreas:1.21 breast:2.02 salivary:1.58
RNA-seq uterus:- placenta:- prostate:0.00 ovary:0.28 testis:1.25 heart:0.03 muscle:0.00 esophagus:- stomach:- intestine:- colon:0.68     liver/hepato:0.00        lung:0.51    bladder:- kidney:0.45 pituitary:- thyroid/parathyroid:0.34 adrenal gland:0.07 pancreas:- breast:0.06 salivary:-

Gene Information

IDs

Refseq ID NM_001130714
Gene ID 51176
Unigene ID -
Probe set ID 221558_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000138795
GTEx ID ENSG00000138795

Orthologous Gene

Mouse[1]  NM_010703
Rat [0]  

Chromosomal Region

4q25  [108,968,701  -  109,090,112]

Gene Family (Interpro ID)

IPR000910  High mobility group, HMG1/HMG2
IPR009071  High mobility group, superfamily

Link to Pubmed  (Pubmed ID)

1783375
1827423
1989880
2010090
7537238
7657162
7958926
8125298
8631802
8757136
9119227
9119228
9308964
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14661054
14759258
14990565
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15489334
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15756419
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20098615
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23001182
23068607
23224985
23325550
23375451
23572277
23770605
23913826
24098538
24394665
24419084
24816145

Gene Ontology  (GO ID)

Biological Process

GO:0046632  alpha-beta T cell differentiation
GO:0060033  anatomical structure regression
GO:0060561  apoptosis involved in morphogenesis
GO:0042100  B cell proliferation
GO:0030509  BMP signaling pathway
GO:0007420  brain development
GO:0060326  cell chemotaxis
GO:0071345  cellular response to cytokine stimulus
GO:0071353  cellular response to interleukin-4
GO:0060710  chorio-allantoic fusion
GO:0021542  dentate gyrus development
GO:0030326  embryonic limb morphogenesis
GO:0001837  epithelial to mesenchymal transition
GO:0048069  eye pigmentation
GO:0060325  face morphogenesis
GO:0021873  forebrain neuroblast division
GO:0021879  forebrain neuron differentiation
GO:0021943  formation of radial glial scaffolds
GO:0048699  generation of neurons
GO:0043966  histone H3 acetylation
GO:0043967  histone H4 acetylation
GO:0021854  hypothalamus development
GO:0006917  induction of apoptosis
GO:0030879  mammary gland development
GO:0048747  muscle fiber development
GO:0043066  negative regulation of apoptosis
GO:0043154  negative regulation of caspase activity
GO:0022408  negative regulation of cell-cell adhesion
GO:0043392  negative regulation of DNA binding
GO:0032696  negative regulation of interleukin-13 production
GO:0032713  negative regulation of interleukin-4 production
GO:0032714  negative regulation of interleukin-5 production
GO:0045843  negative regulation of striated muscle tissue development
GO:0000122  negative regulation of transcription from RNA polymerase II promoter
GO:0045892  negative regulation of transcription, DNA-dependent
GO:0090090  negative regulation of Wnt receptor signaling pathway through beta-catenin
GO:0001755  neural crest cell migration
GO:0022008  neurogenesis
GO:0030223  neutrophil differentiation
GO:0042475  odontogenesis of dentine-containing tooth
GO:0001649  osteoblast differentiation
GO:0060021  palate development
GO:0048341  paraxial mesoderm formation
GO:0001569  patterning of blood vessels
GO:0043923  positive regulation by host of viral transcription
GO:0090068  positive regulation of cell cycle process
GO:0030307  positive regulation of cell growth
GO:0030335  positive regulation of cell migration
GO:0008284  positive regulation of cell proliferation
GO:0022409  positive regulation of cell-cell adhesion
GO:0010718  positive regulation of epithelial to mesenchymal transition
GO:0010628  positive regulation of gene expression
GO:0030854  positive regulation of granulocyte differentiation
GO:0045944  positive regulation of transcription from RNA polymerase II promoter
GO:0045893  positive regulation of transcription, DNA-dependent
GO:0021861  radial glial cell differentiation in the forebrain
GO:0022407  regulation of cell-cell adhesion
GO:0016202  regulation of striated muscle tissue development
GO:0050909  sensory perception of taste
GO:0001756  somitogenesis
GO:0002040  sprouting angiogenesis
GO:0033153  T cell receptor V(D)J recombination
GO:0045063  T-helper 1 cell differentiation
GO:0043586  tongue development
GO:0006366  transcription from RNA polymerase II promoter
GO:0016055  Wnt receptor signaling pathway
GO:0060070  Wnt receptor signaling pathway through beta-catenin

Cellular Component

GO:0005737  cytoplasm
GO:0005634  nucleus
GO:0032993  protein-DNA complex
GO:0005667  transcription factor complex

Molecular Function

GO:0070016  armadillo repeat domain binding
GO:0008013  beta-catenin binding
GO:0070742  C2H2 zinc finger domain binding
GO:0043027  caspase inhibitor activity
GO:0003682  chromatin binding
GO:0008301  DNA bending activity
GO:0003677  DNA binding
GO:0044212  DNA regulatory region binding
GO:0030284  estrogen receptor activity
GO:0030331  estrogen receptor binding
GO:0045295  gamma-catenin binding
GO:0042393  histone binding
GO:0005515  protein binding
GO:0003705  RNA polymerase II transcription factor activity, enhancer binding
GO:0043565  sequence-specific DNA binding
GO:0003700  transcription factor activity
GO:0008134  transcription factor binding