vaccinia related kinase 3

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Synonym

VRK3, Vaccinia-related kinase 3, Serine/threonine-protein kinase VRK3, vaccinia related kinase 3

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:85.30 cerebellum:151.10 brain stem:- corpus callosum/glia:116.60 pineal gland:- peripheral nerve:30.70 spine:112.30 retina:- eye:129.30 artery/aorta:89.90 vein:66.60 lymphnode:20.20 peripheral blood:145.70 spleen:151.30 thymus:154.60 bone marrow:39.40 adipose:- bone:38.40 skin:52.80
GeneChip cerebrum:7.16 cerebellum:6.92 brain stem:7.04 corpus callosum/glia:7.24 pineal gland:- peripheral nerve:7.16 spine:7.21 retina:- eye:- artery/aorta:7.54 vein:7.15 lymphnode:7.74 peripheral blood:- spleen:7.64 thymus:7.71 bone marrow:7.73 adipose:7.54 bone:- skin:7.32
CAGE cerebrum:2.76 cerebellum:- brain stem:2.81 corpus callosum/glia:3.04 pineal gland:3.27 peripheral nerve:- spine:2.71 retina:- eye:- artery/aorta:2.77 vein:2.95 lymphnode:2.88 peripheral blood:- spleen:2.86 thymus:3.52 bone marrow:- adipose:2.81 bone:- skin:-
RNA-seq cerebrum:1.65 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:3.03 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:2.60 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:91.10 placenta:87.40 prostate:67.60 ovary:149.10 testis:307.20 heart:12.80 muscle:40.20 esophagus:- stomach:- intestine:162 colon:84.80     liver/hepato:52.80        lung:78.20    bladder:- kidney:93.60 pituitary:- thyroid/parathyroid:- adrenal gland:50.80 pancreas:62.20 breast:18.60 salivary:328.40
GeneChip uterus:7.28 placenta:7.18 prostate:7.57 ovary:7.72 testis:9.58 heart:7.21 muscle:7.51 esophagus:7.31 stomach:7.37 intestine:7.54 colon:7.66 liver/hepato:7.91 lung:7.41 bladder:- kidney:7.77 pituitary:7.57 thyroid/parathyroid:7.70 adrenal gland:7.43 pancreas:7.64 breast:7.50 salivary:7.47
CAGE uterus:3.07 placenta:2.85 prostate:2.82 ovary:2.95 testis:4.87 heart:2.47 muscle:2.78 esophagus:2.60 stomach:- intestine:3.35 colon:3.07     liver/hepato:3.07    lung:2.78 bladder:2.65 kidney:3.24 pituitary:2.93 thyroid/parathyroid:3.10 adrenal gland:- pancreas:2.90 breast:2.53 salivary:3.34
RNA-seq uterus:- placenta:- prostate:3.29 ovary:3.05 testis:4.47 heart:1.89 muscle:3.23 esophagus:- stomach:- intestine:- colon:2.54     liver/hepato:2.85        lung:2.39    bladder:- kidney:3.64 pituitary:- thyroid/parathyroid:2.95 adrenal gland:2.67 pancreas:- breast:2.60 salivary:-

Gene Information

IDs

Refseq ID NM_016440
Gene ID 51231
Unigene ID Hs.443330
Probe set ID 218022_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000105053
GTEx ID ENSG00000105053

Orthologous Gene

Mouse[1]  NM_133945
Rat[1]  NM_001005561

Chromosomal Region

19q13.33  [50,479,726  -  50,528,805]

Gene Family (Interpro ID)

IPR000719  Protein kinase, catalytic domain
IPR011009  Protein kinase-like domain
IPR002290  Serine/threonine-protein kinase domain
IPR017442  Serine/threonine-protein kinase-like domain

Link to Pubmed  (Pubmed ID)

8125298
12477932
14645249
15489334
17353931
18617507
21890473
21900206
23082977
24250222

Gene Ontology  (GO ID)

Biological Process

GO:0070373  negative regulation of ERK1 and ERK2 cascade
GO:0032516  positive regulation of phosphoprotein phosphatase activity

Cellular Component

GO:0005634  nucleus

Molecular Function

GO:0005524  ATP binding
GO:0004672  protein kinase activity
GO:0019903  protein phosphatase binding