TAO kinase 3

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Synonym

JNK/SAPK-inhibitory kinase, Jun kinase-inhibitory kinase, JIK, FLJ31808, Cutaneous T-cell lymphoma tumor antigen HD-CL-09, TAOK3, TAO kinase 3, Thousand and one amino acid protein 3, Serine/threonine-protein kinase TAO3, hKFC-A, CTCL tumor antigen HD-CL-09, Dendritic cell-derived protein kinase, DPK, Kinase from chicken homolog A, KDS, MAP3K18, DKFZp666H245

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:- cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
GeneChip cerebrum:7.52 cerebellum:7.28 brain stem:7.24 corpus callosum/glia:7.50 pineal gland:- peripheral nerve:6.92 spine:7.20 retina:- eye:- artery/aorta:6.57 vein:6.51 lymphnode:7.24 peripheral blood:- spleen:7.03 thymus:7.53 bone marrow:7.01 adipose:6.40 bone:- skin:6.72
CAGE cerebrum:4.24 cerebellum:- brain stem:4.28 corpus callosum/glia:4.08 pineal gland:4.73 peripheral nerve:- spine:4.42 retina:- eye:- artery/aorta:3.65 vein:3.99 lymphnode:4.06 peripheral blood:- spleen:4.36 thymus:4.36 bone marrow:- adipose:3.88 bone:- skin:-
RNA-seq cerebrum:3.04 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:3.30 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:2.89 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:3.60 prostate:- ovary:- testis:- heart:- muscle:- esophagus:- stomach:- intestine:- colon:-     liver/hepato:-        lung:4.90    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-
GeneChip uterus:6.95 placenta:6.28 prostate:8.10 ovary:6.72 testis:6.16 heart:6.43 muscle:6 esophagus:7.12 stomach:6.94 intestine:6.45 colon:5.99 liver/hepato:6.30 lung:7.19 bladder:- kidney:6.33 pituitary:7.25 thyroid/parathyroid:7.22 adrenal gland:6.92 pancreas:5.42 breast:6.82 salivary:6.35
CAGE uterus:3.87 placenta:3.50 prostate:4.02 ovary:3.52 testis:3.41 heart:3.68 muscle:3.79 esophagus:3.92 stomach:- intestine:4.62 colon:4.16     liver/hepato:3.29    lung:4.04 bladder:3.96 kidney:3.64 pituitary:4.17 thyroid/parathyroid:3.91 adrenal gland:- pancreas:3.10 breast:3.78 salivary:3.84
RNA-seq uterus:- placenta:- prostate:3.64 ovary:3.22 testis:3.18 heart:2.80 muscle:2.82 esophagus:- stomach:- intestine:- colon:3.10     liver/hepato:2.39        lung:2.80    bladder:- kidney:3.26 pituitary:- thyroid/parathyroid:3.70 adrenal gland:3.11 pancreas:- breast:3.11 salivary:-

Gene Information

IDs

Refseq ID NM_016281
Gene ID 51347
Unigene ID Hs.644420
Probe set ID 220761_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000135090
GTEx ID ENSG00000135090

Orthologous Gene

Mouse[6]  NM_001081308, NM_001199685, NM_183306
Rat[1]  NM_001024254, NM_001199685, NM_183306

Chromosomal Region

12q24.23  [118,587,606  -  118,810,750]

Gene Family (Interpro ID)

IPR000719  Protein kinase, catalytic domain
IPR011009  Protein kinase-like domain
IPR002290  Serine/threonine-protein kinase domain
IPR017442  Serine/threonine-protein kinase-like domain
IPR001245  Tyrosine-protein kinase, catalytic domain
IPR020635  Tyrosine-protein kinase, subgroup, catalytic domain

Link to Pubmed  (Pubmed ID)

10559204
10924369
11278723
12477932
13679851
14702039
14996095
15489334
16344560
17396146
17478428
18029348
20195357
20379614
20949042
22939624
24250222
24816145

Gene Ontology  (GO ID)

Biological Process

GO:0006281  DNA repair
GO:0031572  G2/M transition DNA damage checkpoint
GO:0000165  MAPKKK cascade
GO:0046329  negative regulation of JNK cascade
GO:0006469  negative regulation of protein kinase activity
GO:0046330  positive regulation of JNK cascade
GO:0043507  positive regulation of JUN kinase activity
GO:0032874  positive regulation of stress-activated MAPK cascade
GO:0046777  protein amino acid autophosphorylation
GO:0006468  protein amino acid phosphorylation
GO:0006974  response to DNA damage stimulus

Cellular Component

GO:0005739  mitochondrion
GO:0005886  plasma membrane

Molecular Function

GO:0005524  ATP binding
GO:0005515  protein binding
GO:0004860  protein kinase inhibitor activity
GO:0004674  protein serine/threonine kinase activity
GO:0016740  transferase activity