phosphodiesterase 2A, cGMP-stimulated

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Synonym

Cyclic GMP-stimulated phosphodiesterase, CGS-PDE, cGSPDE, PDE2A1, PED2A4, phosphodiesterase 2A, cGMP-stimulated, cGMP-dependent 3',5'-cyclic phosphodiesterase, PDE2A

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:263.10 cerebellum:37.80 brain stem:- corpus callosum/glia:29.20 pineal gland:- peripheral nerve:30.70 spine:224.60 retina:- eye:35.30 artery/aorta:30 vein:- lymphnode:10.10 peripheral blood:18.20 spleen:226.90 thymus:64.40 bone marrow:19.70 adipose:80.70 bone:- skin:33.60
GeneChip cerebrum:7.78 cerebellum:5.01 brain stem:6.46 corpus callosum/glia:6.42 pineal gland:- peripheral nerve:6.32 spine:5.75 retina:- eye:- artery/aorta:6.89 vein:6.77 lymphnode:6.54 peripheral blood:- spleen:9.65 thymus:4.73 bone marrow:5.65 adipose:7.85 bone:- skin:7.03
CAGE cerebrum:3.58 cerebellum:- brain stem:2.61 corpus callosum/glia:2.51 pineal gland:4.10 peripheral nerve:- spine:1.56 retina:- eye:- artery/aorta:2.46 vein:2.60 lymphnode:1.97 peripheral blood:- spleen:4.10 thymus:0.50 bone marrow:- adipose:4.15 bone:- skin:-
RNA-seq cerebrum:1.31 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:0.00 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0.00 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:100.20 placenta:18.20 prostate:33.80 ovary:298.10 testis:30.30 heart:76.60 muscle:20.10 esophagus:- stomach:- intestine:64.80 colon:8.50     liver/hepato:21.10        lung:14.70    bladder:- kidney:10.40 pituitary:- thyroid/parathyroid:- adrenal gland:101.60 pancreas:8.90 breast:9.30 salivary:-
GeneChip uterus:6.20 placenta:5.92 prostate:5.80 ovary:6.13 testis:5.56 heart:7.20 muscle:5.71 esophagus:6.51 stomach:6.32 intestine:6.23 colon:6.57 liver/hepato:6.56 lung:6.49 bladder:- kidney:6.55 pituitary:6.26 thyroid/parathyroid:6.34 adrenal gland:8.59 pancreas:5.70 breast:7.02 salivary:5.26
CAGE uterus:2.96 placenta:1.43 prostate:2.58 ovary:2.19 testis:1.84 heart:2.91 muscle:2.36 esophagus:2.08 stomach:- intestine:1.79 colon:2.66     liver/hepato:2.07    lung:2.02 bladder:2.78 kidney:2.15 pituitary:1.88 thyroid/parathyroid:2.10 adrenal gland:- pancreas:0.94 breast:4.35 salivary:1.28
RNA-seq uterus:- placenta:- prostate:0 ovary:0.00 testis:0.00 heart:0.13 muscle:0 esophagus:- stomach:- intestine:- colon:0.05     liver/hepato:0.00        lung:0    bladder:- kidney:0 pituitary:- thyroid/parathyroid:0.00 adrenal gland:0.00 pancreas:- breast:0.00 salivary:-

Gene Information

IDs

Refseq ID NM_002599
Gene ID 5138
Unigene ID Hs.503163
Probe set ID 204134_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000186642
GTEx ID ENSG00000186642

Orthologous Gene

Mouse[3]  NM_001008548, NM_001143848, NM_001143849
Rat[2]  NM_001143847, NM_031079, NM_001143849

Chromosomal Region

11q13.4  [72,287,185  -  72,385,635]

Gene Family (Interpro ID)

IPR003018  GAF
IPR003607  Metal-dependent phosphohydrolase, HD domain

Link to Pubmed  (Pubmed ID)

8557689
9210593
10375378
11156964
12038792
12271124
12477932
14687666
14702039
15650061
15938621
16344560
17329248
17704206
19252089
19390057
19506089
19689430
19828435
19913121
20351714
20395239
20628086
21697861
21724846
21766240
21987572
22446963
23381931
23810893
23899287

Gene Ontology  (GO ID)

Biological Process

GO:0007596  blood coagulation
GO:0070588  calcium ion transmembrane transport
GO:0006198  cAMP catabolic process
GO:0019933  cAMP-mediated signaling
GO:0071321  cellular response to cGMP
GO:0071260  cellular response to mechanical stimulus
GO:0046069  cGMP catabolic process
GO:0019934  cGMP-mediated signaling
GO:0008152  metabolic process
GO:0030224  monocyte differentiation
GO:0030818  negative regulation of cAMP biosynthetic process
GO:0033159  negative regulation of protein import into nucleus, translocation
GO:0000122  negative regulation of transcription from RNA polymerase II promoter
GO:0043116  negative regulation of vascular permeability
GO:0050729  positive regulation of inflammatory response
GO:0043117  positive regulation of vascular permeability
GO:0006626  protein targeting to mitochondrion

Cellular Component

GO:0030424  axon
GO:0005737  cytoplasm
GO:0005829  cytosol
GO:0030425  dendrite
GO:0005783  endoplasmic reticulum
GO:0005794  Golgi apparatus
GO:0005759  mitochondrial matrix
GO:0005634  nucleus
GO:0048471  perinuclear region of cytoplasm
GO:0005886  plasma membrane
GO:0042734  presynaptic membrane

Molecular Function

GO:0005262  calcium channel activity
GO:0030552  cAMP binding
GO:0030553  cGMP binding
GO:0004118  cGMP-stimulated cyclic-nucleotide phosphodiesterase activity
GO:0004112  cyclic-nucleotide phosphodiesterase activity
GO:0008144  drug binding
GO:0046872  metal ion binding
GO:0005515  protein binding
GO:0042803  protein homodimerization activity
GO:0030911  TPR domain binding