TP53 regulated inhibitor of apoptosis 1

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Synonym

TP53-regulated inhibitor of apoptosis 1, Protein 15E1.1, P53CSV, HSPC132, p53-inducible cell-survival factor, TP53 regulated inhibitor of apoptosis 1, 15E1.1, TRIAP1, WF-1, p53CSV

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:8.30 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:30.70 spine:- retina:- eye:29.40 artery/aorta:30 vein:133.30 lymphnode:60.70 peripheral blood:18.20 spleen:- thymus:25.80 bone marrow:- adipose:- bone:- skin:14.40
GeneChip cerebrum:6.83 cerebellum:6.67 brain stem:6.83 corpus callosum/glia:6.79 pineal gland:- peripheral nerve:6.90 spine:6.66 retina:- eye:- artery/aorta:7.15 vein:6.92 lymphnode:7.15 peripheral blood:- spleen:6.83 thymus:7.42 bone marrow:6.77 adipose:7.25 bone:- skin:7.64
CAGE cerebrum:2.37 cerebellum:- brain stem:2.36 corpus callosum/glia:2.06 pineal gland:1.65 peripheral nerve:- spine:2.23 retina:- eye:- artery/aorta:2.68 vein:2.57 lymphnode:2.48 peripheral blood:- spleen:2.39 thymus:2.23 bone marrow:- adipose:2.31 bone:- skin:-
RNA-seq cerebrum:3.77 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:3.78 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:3.62 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:36.50 placenta:58.30 prostate:22.50 ovary:- testis:13 heart:- muscle:40.20 esophagus:- stomach:- intestine:64.80 colon:-     liver/hepato:31.70        lung:24.40    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:50.80 pancreas:- breast:18.60 salivary:-
GeneChip uterus:7.19 placenta:7.39 prostate:7.44 ovary:7.39 testis:7.11 heart:7.12 muscle:8.41 esophagus:7.40 stomach:7 intestine:7.46 colon:7.16 liver/hepato:7.77 lung:7.10 bladder:- kidney:7.05 pituitary:6.82 thyroid/parathyroid:6.92 adrenal gland:7.24 pancreas:7.68 breast:7.53 salivary:7.17
CAGE uterus:2.15 placenta:2.73 prostate:2.44 ovary:2.06 testis:2.38 heart:2.65 muscle:2.82 esophagus:2.41 stomach:- intestine:2.44 colon:2.46     liver/hepato:3.06    lung:2.43 bladder:2.14 kidney:2.46 pituitary:2.14 thyroid/parathyroid:2.26 adrenal gland:- pancreas:3.42 breast:3.12 salivary:3.11
RNA-seq uterus:- placenta:- prostate:4.02 ovary:3.82 testis:4.15 heart:3.01 muscle:3.51 esophagus:- stomach:- intestine:- colon:4.23     liver/hepato:4.46        lung:3.20    bladder:- kidney:4.03 pituitary:- thyroid/parathyroid:4.37 adrenal gland:4.41 pancreas:- breast:4.70 salivary:-

Gene Information

IDs

Refseq ID NM_016399
Gene ID 51499
Unigene ID Hs.69499
Probe set ID 218403_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000170855
GTEx ID ENSG00000170855

Orthologous Gene

Mouse[1]  NM_026933
Rat[1]  NM_001126099

Chromosomal Region

12q24.31  [120,881,764  -  120,884,215]

Gene Family (Interpro ID)

-

Link to Pubmed  (Pubmed ID)

11042152
12477932
15489334
15735003
15735665
16541075
16712791
19171422
20877624
21890473
21901158
21988832
23684607
23824909
23931759

Gene Ontology  (GO ID)

Biological Process

GO:0034644  cellular response to UV
GO:0030330  DNA damage response, signal transduction by p53 class mediator
GO:0006977  DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0043154  negative regulation of caspase activity
GO:0045944  positive regulation of transcription from RNA polymerase II promoter

Cellular Component

GO:0005739  mitochondrion
GO:0048471  perinuclear region of cytoplasm

Molecular Function

GO:0043027  caspase inhibitor activity
GO:0005515  protein binding