platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)

Synonym

PDGFB, FLJ12858, PDGF2, SIS, c-sis, PDGF-2, Platelet-derived growth factor beta polypeptide, SSV, PDGF B-chain, Becaplermin, Platelet-derived growth factor B chain precursor

normal 40 tissues
cell lines, primary cells, adult tissues and fetal tissues (FANTOM5 CAGE)

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain

blood

connective

EST

cerebrum:-

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:5.90

artery/aorta:-

vein:-

lymphnode:-

peripheral blood:-

spleen:18.90

thymus:-

bone marrow:-

adipose:-

bone:-

skin:-

GeneChip

cerebrum:6.80

cerebellum:6.97

brain stem:6.81

corpus callosum/glia:6.78

pineal gland:-

peripheral nerve:6.73

spine:6.72

retina:-

eye:-

artery/aorta:6.81

vein:6.88

lymphnode:6.79

peripheral blood:-

spleen:6.61

thymus:6.02

bone marrow:6.64

adipose:7.14

bone:-

skin:6.78

CAGE

cerebrum:2.35

cerebellum:-

brain stem:2.72

corpus callosum/glia:3.04

pineal gland:2.23

peripheral nerve:-

spine:2.81

retina:-

eye:-

artery/aorta:2.68

vein:2.74

lymphnode:1.69

peripheral blood:-

spleen:1.62

thymus:0.94

bone marrow:-

adipose:3.31

bone:-

skin:-

RNA-seq

cerebrum:0.39

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:1.29

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:1.32

bone:-

skin:-

reproductive

muscular

alimentary

liver

lung

urinary

endo/exo-crine

EST

uterus:-

placenta:-

prostate:-

ovary:-

testis:-

heart:-

muscle:-

esophagus:-

stomach:-

intestine:-

colon:8.50

liver/hepato:-

lung:-

bladder:-

kidney:41.60

pituitary:-

thyroid/parathyroid:-

adrenal gland:-

pancreas:-

breast:-

salivary:-

GeneChip

uterus:6.58

placenta:7.09

prostate:6.32

ovary:6.63

testis:6.39

heart:7.16

muscle:7.01

esophagus:6.79

stomach:6.73

intestine:6.80

colon:6.90

liver/hepato:6.63

lung:7

bladder:-

kidney:6.98

pituitary:6.71

thyroid/parathyroid:6.84

adrenal gland:6.98

pancreas:7.17

breast:6.76

salivary:6.70

CAGE

uterus:2.78

placenta:3.82

prostate:2.11

ovary:2.04

testis:2.33

heart:3.25

muscle:2.70

esophagus:2.46

stomach:-

intestine:1.74

colon:2.60

liver/hepato:1.07

lung:3.42

bladder:2.51

kidney:2.59

pituitary:1.60

thyroid/parathyroid:2.37

adrenal gland:-

pancreas:1.87

breast:3.66

salivary:1.67

RNA-seq

uterus:-

placenta:-

prostate:1.13

ovary:0.36

testis:0.67

heart:1.39

muscle:0.84

esophagus:-

stomach:-

intestine:-

colon:0.73

liver/hepato:0.08

lung:3.49

bladder:-

kidney:1.41

pituitary:-

thyroid/parathyroid:0.49

adrenal gland:0.87

pancreas:-

breast:1.13

salivary:-

IDs

Refseq ID	NM_002608
Gene ID	5155
Unigene ID	Hs.197613
Probe set ID	216061_x_at [HG-U133_Plus_2]
Ensembl ID	ENSG00000100311
GTEx ID	ENSG00000100311

Orthologous Gene

Mouse[2]	NM_011057
Rat[2]	NM_031524

Chromosomal Region

22q13.1 [39,619,364 - 39,640,756]

Search genes near this gene
- Between -5kb and +5kb
- Between -10kb and +10kb

Gene Family (Interpro ID)

Gene Ontology (GO ID)

Biological Process

GO:0030036	actin cytoskeleton organization
GO:0032147	activation of protein kinase activity
GO:0032148	activation of protein kinase B activity
GO:0007596	blood coagulation
GO:0048514	blood vessel morphogenesis
GO:0060445	branching involved in salivary gland morphogenesis
GO:0060326	cell chemotaxis
GO:0016049	cell growth
GO:0030031	cell projection assembly
GO:0071363	cellular response to growth factor stimulus
GO:0071506	cellular response to mycophenolic acid
GO:0006260	DNA replication
GO:0001892	embryonic placenta development
GO:0007173	epidermal growth factor receptor signaling pathway
GO:0060664	epithelial cell proliferation involved in salivary gland morphogenesis
GO:0030198	extracellular matrix organization
GO:0008543	fibroblast growth factor receptor signaling pathway
GO:0007507	heart development
GO:0030097	hemopoiesis
GO:0045087	innate immune response
GO:0002548	monocyte chemotaxis
GO:0030336	negative regulation of cell migration
GO:0010512	negative regulation of phosphatidylinositol biosynthetic process
GO:0010544	negative regulation of platelet activation
GO:0045892	negative regulation of transcription, DNA-dependent
GO:0048011	nerve growth factor receptor signaling pathway
GO:0018105	peptidyl-serine phosphorylation
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0048015	phosphoinositide-mediated signaling
GO:0030168	platelet activation
GO:0002576	platelet degranulation
GO:0048008	platelet-derived growth factor receptor signaling pathway
GO:0050918	positive chemotaxis
GO:0043536	positive regulation of blood vessel endothelial cell migration
GO:0051781	positive regulation of cell division
GO:0030335	positive regulation of cell migration
GO:0008284	positive regulation of cell proliferation
GO:0050921	positive regulation of chemotaxis
GO:0045737	positive regulation of cyclin-dependent protein kinase activity
GO:0045740	positive regulation of DNA replication
GO:0001938	positive regulation of endothelial cell proliferation
GO:0070374	positive regulation of ERK1 and ERK2 cascade
GO:0045743	positive regulation of fibroblast growth factor receptor signaling pathway
GO:0048146	positive regulation of fibroblast proliferation
GO:0003104	positive regulation of glomerular filtration
GO:0043406	positive regulation of MAP kinase activity
GO:0043410	positive regulation of MAPKKK cascade
GO:0045840	positive regulation of mitosis
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation
GO:0043552	positive regulation of phosphoinositide 3-kinase activity
GO:0014068	positive regulation of phosphoinositide 3-kinase cascade
GO:0031954	positive regulation of protein amino acid autophosphorylation
GO:0014911	positive regulation of smooth muscle cell migration
GO:0048661	positive regulation of smooth muscle cell proliferation
GO:0045893	positive regulation of transcription, DNA-dependent
GO:0006468	protein amino acid phosphorylation
GO:0042493	response to drug
GO:0032355	response to estradiol stimulus
GO:0001666	response to hypoxia
GO:0032868	response to insulin stimulus
GO:0009611	response to wounding
GO:0006929	substrate-bound cell migration
GO:0007179	transforming growth factor beta receptor signaling pathway

Cellular Component

GO:0016323	basolateral plasma membrane
GO:0009986	cell surface
GO:0005737	cytoplasm
GO:0005788	endoplasmic reticulum lumen
GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0000139	Golgi membrane
GO:0031093	platelet alpha granule lumen

Molecular Function

GO:0042056	chemoattractant activity
GO:0005518	collagen binding
GO:0008083	growth factor activity
GO:0048407	platelet-derived growth factor binding
GO:0005161	platelet-derived growth factor receptor binding
GO:0005515	protein binding
GO:0046982	protein heterodimerization activity
GO:0042803	protein homodimerization activity
GO:0016176	superoxide-generating NADPH oxidase activator activity

platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)

Synonym

Expression Pattern

Choropleth map on BodyParts3D

Classification in 40 Organs

Gene Information

IDs

Orthologous Gene

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

Cellular Component

Molecular Function