platelet-derived growth factor receptor, alpha polypeptide

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Synonym

PDGFR2, PDGF-R-alpha, CD140A, CD140a antigen, CD140a, PDGFRA, MGC74795

normal 40 tissues
cell lines, primary cells, adult tissues and fetal tissues (FANTOM5 CAGE)

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain

blood

connective

EST

cerebrum:53.30

cerebellum:-

brain stem:-

corpus callosum/glia:29.20

pineal gland:-

peripheral nerve:306.70

spine:112.30

retina:-

eye:82.30

artery/aorta:149.90

vein:-

lymphnode:10.10

peripheral blood:-

spleen:113.40

thymus:38.70

bone marrow:39.40

adipose:121

bone:115.20

skin:-

GeneChip

cerebrum:7.10

cerebellum:5.41

brain stem:7.10

corpus callosum/glia:7.42

pineal gland:-

peripheral nerve:7.82

spine:7.53

retina:-

eye:-

artery/aorta:8.71

vein:8.16

lymphnode:7.18

peripheral blood:-

spleen:9.30

thymus:6.39

bone marrow:5.26

adipose:8.75

bone:-

skin:8.21

CAGE

cerebrum:3.10

cerebellum:-

brain stem:3.52

corpus callosum/glia:3.60

pineal gland:3.07

peripheral nerve:-

spine:3.80

retina:-

eye:-

artery/aorta:4.20

vein:3.66

lymphnode:3.76

peripheral blood:-

spleen:5.23

thymus:1.49

bone marrow:-

adipose:4.90

bone:-

skin:-

RNA-seq

cerebrum:2.38

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:5.69

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:5.73

bone:-

skin:-

reproductive

muscular

alimentary

liver

lung

urinary

endo/exo-crine

EST

uterus:200.50

placenta:69.20

prostate:45.10

ovary:335.40

testis:43.30

heart:153.30

muscle:40.20

esophagus:-

stomach:-

intestine:64.80

colon:25.40

liver/hepato:42.20

lung:88

bladder:-

kidney:31.20

pituitary:-

thyroid/parathyroid:-

adrenal gland:-

pancreas:26.70

breast:27.90

salivary:-

GeneChip

uterus:9.39

placenta:7.45

prostate:7.89

ovary:9.70

testis:7.21

heart:8.35

muscle:7.33

esophagus:7.53

stomach:9.14

intestine:8.65

colon:8.34

liver/hepato:6.94

lung:8.66

bladder:-

kidney:6.71

pituitary:5.24

thyroid/parathyroid:7.10

adrenal gland:9.25

pancreas:7.27

breast:8.49

salivary:6.41

CAGE

uterus:4.78

placenta:3.84

prostate:4.30

ovary:5.36

testis:3.89

heart:4.01

muscle:3.11

esophagus:4.41

stomach:-

intestine:4.18

colon:4.05

liver/hepato:3.39

lung:4.12

bladder:4.89

kidney:4.41

pituitary:2.02

thyroid/parathyroid:3.71

adrenal gland:-

pancreas:2.94

breast:4.20

salivary:2.88

RNA-seq

uterus:-

placenta:-

prostate:4.87

ovary:5.93

testis:5.14

heart:3.31

muscle:2.14

esophagus:-

stomach:-

intestine:-

colon:5.64

liver/hepato:2.92

lung:4.30

bladder:-

kidney:4.90

pituitary:-

thyroid/parathyroid:4.08

adrenal gland:3.92

pancreas:-

breast:3.77

salivary:-

IDs

Refseq ID	NM_006206
Gene ID	5156
Unigene ID	Hs.74615
Probe set ID	203131_at [HG-U133_Plus_2]
Ensembl ID	ENSG00000134853
GTEx ID	ENSG00000134853

Orthologous Gene

Mouse[4]	NM_001083316, NM_011058
Rat[3]	NM_012802, NM_011058

Chromosomal Region

4q12 [55,095,264 - 55,164,414]

Search genes near this gene
- Between -5kb and +5kb
- Between -10kb and +10kb

Gene Family (Interpro ID)

Gene Ontology (GO ID)

Biological Process

GO:0030325	adrenal gland development
GO:0055003	cardiac myofibril assembly
GO:0001775	cell activation
GO:0060326	cell chemotaxis
GO:0071230	cellular response to amino acid stimulus
GO:0007204	elevation of cytosolic calcium ion concentration
GO:0048701	embryonic cranial skeleton morphogenesis
GO:0048557	embryonic digestive tract morphogenesis
GO:0048704	embryonic skeletal system morphogenesis
GO:0007173	epidermal growth factor receptor signaling pathway
GO:0008210	estrogen metabolic process
GO:0030198	extracellular matrix organization
GO:0060325	face morphogenesis
GO:0008543	fibroblast growth factor receptor signaling pathway
GO:0001701	in utero embryonic development
GO:0045087	innate immune response
GO:0033327	Leydig cell differentiation
GO:0030324	lung development
GO:0001553	luteinization
GO:0030539	male genitalia development
GO:0010544	negative regulation of platelet activation
GO:0048011	nerve growth factor receptor signaling pathway
GO:0042475	odontogenesis of dentine-containing tooth
GO:0060021	palate development
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0048015	phosphoinositide-mediated signaling
GO:0070527	platelet aggregation
GO:0048008	platelet-derived growth factor receptor signaling pathway
GO:0030335	positive regulation of cell migration
GO:0008284	positive regulation of cell proliferation
GO:0045740	positive regulation of DNA replication
GO:0070374	positive regulation of ERK1 and ERK2 cascade
GO:0048146	positive regulation of fibroblast proliferation
GO:0043552	positive regulation of phosphoinositide 3-kinase activity
GO:0014068	positive regulation of phosphoinositide 3-kinase cascade
GO:0010863	positive regulation of phospholipase C activity
GO:0046777	protein amino acid autophosphorylation
GO:0050920	regulation of chemotaxis
GO:0048010	vascular endothelial growth factor receptor signaling pathway
GO:0019048	virus-host interaction
GO:0042060	wound healing

Cellular Component

GO:0005737	cytoplasm
GO:0009897	external side of plasma membrane
GO:0005887	integral to plasma membrane
GO:0031226	intrinsic to plasma membrane
GO:0005634	nucleus
GO:0005886	plasma membrane

Molecular Function

GO:0005524	ATP binding
GO:0005018	platelet-derived growth factor alpha-receptor activity
GO:0048407	platelet-derived growth factor binding
GO:0005161	platelet-derived growth factor receptor binding
GO:0005515	protein binding
GO:0042803	protein homodimerization activity
GO:0004714	transmembrane receptor protein tyrosine kinase activity
GO:0005021	vascular endothelial growth factor receptor activity

IPR000719	Protein kinase, catalytic domain
IPR011009	Protein kinase-like domain
IPR002290	Serine/threonine-protein kinase domain
IPR017442	Serine/threonine-protein kinase-like domain
IPR020685	Tyrosine-protein kinase
IPR001245	Tyrosine-protein kinase, catalytic domain
IPR016243	Tyrosine-protein kinase, CSF-1/PDGF receptor
IPR020933	Tyrosine-protein kinase, fibroblast growth factor receptor, conserved region
IPR020635	Tyrosine-protein kinase, subgroup, catalytic domain
IPR009134	Tyrosine-protein kinase, vascular endothelial growth factor receptor (VEGFR), N-terminal

platelet-derived growth factor receptor, alpha polypeptide

Synonym

Expression Pattern

Choropleth map on BodyParts3D

Classification in 40 Organs

Gene Information

IDs

Orthologous Gene

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

Cellular Component

Molecular Function