platelet-derived growth factor receptor, beta polypeptide

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Synonym

PDGF-R-beta, CD140b antigen, PDGFRB, PDGFR1, PDGFR, JTK12, CD140b, CD140B

normal 40 tissues
cell lines, primary cells, adult tissues and fetal tissues (FANTOM5 CAGE)

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain

blood

connective

EST

cerebrum:47.40

cerebellum:-

brain stem:-

corpus callosum/glia:29.20

pineal gland:-

peripheral nerve:184

spine:336.90

retina:-

eye:135.20

artery/aorta:30

vein:66.60

lymphnode:-

peripheral blood:36.40

spleen:94.50

thymus:-

bone marrow:19.70

adipose:-

bone:115.20

skin:72

GeneChip

cerebrum:6.85

cerebellum:6.33

brain stem:6.82

corpus callosum/glia:6.93

pineal gland:-

peripheral nerve:7.99

spine:6.75

retina:-

eye:-

artery/aorta:8.63

vein:8.93

lymphnode:7.62

peripheral blood:-

spleen:7.98

thymus:6.01

bone marrow:6.19

adipose:8.57

bone:-

skin:8.04

CAGE

cerebrum:3.40

cerebellum:-

brain stem:3.46

corpus callosum/glia:3.48

pineal gland:2.80

peripheral nerve:-

spine:3.34

retina:-

eye:-

artery/aorta:5.35

vein:4.50

lymphnode:4.02

peripheral blood:-

spleen:4.44

thymus:2.00

bone marrow:-

adipose:5.62

bone:-

skin:-

RNA-seq

cerebrum:2.39

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:5.73

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:6.35

bone:-

skin:-

reproductive

muscular

alimentary

liver

lung

urinary

endo/exo-crine

EST

uterus:136.70

placenta:54.60

prostate:90.10

ovary:298.10

testis:56.20

heart:89.40

muscle:-

esophagus:-

stomach:63.70

intestine:-

colon:59.40

liver/hepato:10.60

lung:97.80

bladder:-

kidney:52

pituitary:-

thyroid/parathyroid:-

adrenal gland:-

pancreas:62.20

breast:65.10

salivary:-

GeneChip

uterus:9.13

placenta:8.10

prostate:7.35

ovary:8.58

testis:7.12

heart:8.25

muscle:6.99

esophagus:7.39

stomach:7.52

intestine:7.83

colon:7.75

liver/hepato:6.76

lung:8.65

bladder:-

kidney:7.41

pituitary:6.92

thyroid/parathyroid:7.62

adrenal gland:8

pancreas:7.07

breast:8.50

salivary:6.62

CAGE

uterus:5.60

placenta:4.61

prostate:4.75

ovary:5.33

testis:4.44

heart:4.69

muscle:4.76

esophagus:4.59

stomach:-

intestine:3.31

colon:4.16

liver/hepato:2.78

lung:4.66

bladder:4.67

kidney:3.96

pituitary:1.99

thyroid/parathyroid:4.27

adrenal gland:-

pancreas:2.94

breast:5.75

salivary:3.05

RNA-seq

uterus:-

placenta:-

prostate:4.92

ovary:5.45

testis:5.22

heart:3.54

muscle:3.56

esophagus:-

stomach:-

intestine:-

colon:4.74

liver/hepato:1.57

lung:5.52

bladder:-

kidney:4.17

pituitary:-

thyroid/parathyroid:4.31

adrenal gland:4.98

pancreas:-

breast:4.88

salivary:-

IDs

Refseq ID	NM_002609
Gene ID	5159
Unigene ID	Hs.509067
Probe set ID	202273_at [HG-U133_Plus_2]
Ensembl ID	ENSG00000113721
GTEx ID	ENSG00000113721

Orthologous Gene

Mouse[4]	NM_001146268, NM_008809
Rat [0]

Chromosomal Region

5q32 [149,493,400 - 149,535,423]

Search genes near this gene
- Between -5kb and +5kb
- Between -10kb and +10kb

Gene Family (Interpro ID)

Gene Ontology (GO ID)

Biological Process

GO:0030325	adrenal gland development
GO:0055003	cardiac myofibril assembly
GO:0060326	cell chemotaxis
GO:0016477	cell migration
GO:0060981	cell migration involved in coronary angiogenesis
GO:0007173	epidermal growth factor receptor signaling pathway
GO:0008543	fibroblast growth factor receptor signaling pathway
GO:0006024	glycosaminoglycan biosynthetic process
GO:0001701	in utero embryonic development
GO:0045087	innate immune response
GO:0048839	inner ear development
GO:0048011	nerve growth factor receptor signaling pathway
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0046488	phosphatidylinositol metabolic process
GO:0048015	phosphoinositide-mediated signaling
GO:0048008	platelet-derived growth factor receptor signaling pathway
GO:0030335	positive regulation of cell migration
GO:0008284	positive regulation of cell proliferation
GO:0050921	positive regulation of chemotaxis
GO:0032967	positive regulation of collagen biosynthetic process
GO:0070374	positive regulation of ERK1 and ERK2 cascade
GO:0043406	positive regulation of MAP kinase activity
GO:0045840	positive regulation of mitosis
GO:0043552	positive regulation of phosphoinositide 3-kinase activity
GO:0014068	positive regulation of phosphoinositide 3-kinase cascade
GO:0010863	positive regulation of phospholipase C activity
GO:0032516	positive regulation of phosphoprotein phosphatase activity
GO:0014911	positive regulation of smooth muscle cell migration
GO:0048661	positive regulation of smooth muscle cell proliferation
GO:0046777	protein amino acid autophosphorylation
GO:0007243	protein kinase cascade
GO:0032956	regulation of actin cytoskeleton organization
GO:0050730	regulation of peptidyl-tyrosine phosphorylation
GO:0032355	response to estradiol stimulus
GO:0034405	response to fluid shear stress
GO:0042542	response to hydrogen peroxide
GO:0055093	response to hyperoxia
GO:0032526	response to retinoic acid
GO:0009636	response to toxin
GO:0007165	signal transduction
GO:0048705	skeletal system morphogenesis
GO:0048745	smooth muscle tissue development
GO:0001894	tissue homeostasis
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0048010	vascular endothelial growth factor receptor signaling pathway
GO:0042060	wound healing

Cellular Component

GO:0016324	apical plasma membrane
GO:0005737	cytoplasm
GO:0016023	cytoplasmic membrane-bounded vesicle
GO:0005887	integral to plasma membrane
GO:0031226	intrinsic to plasma membrane
GO:0043202	lysosomal lumen
GO:0016020	membrane
GO:0005634	nucleus
GO:0005886	plasma membrane

Molecular Function

GO:0005524	ATP binding
GO:0043548	phosphoinositide 3-kinase binding
GO:0004992	platelet activating factor receptor activity
GO:0005019	platelet-derived growth factor beta-receptor activity
GO:0048407	platelet-derived growth factor binding
GO:0005017	platelet-derived growth factor receptor activity
GO:0005161	platelet-derived growth factor receptor binding
GO:0005515	protein binding
GO:0004713	protein tyrosine kinase activity
GO:0005102	receptor binding
GO:0005021	vascular endothelial growth factor receptor activity

IPR000719	Protein kinase, catalytic domain
IPR011009	Protein kinase-like domain
IPR002290	Serine/threonine-protein kinase domain
IPR017442	Serine/threonine-protein kinase-like domain
IPR020685	Tyrosine-protein kinase
IPR001245	Tyrosine-protein kinase, catalytic domain
IPR016243	Tyrosine-protein kinase, CSF-1/PDGF receptor
IPR020933	Tyrosine-protein kinase, fibroblast growth factor receptor, conserved region
IPR020635	Tyrosine-protein kinase, subgroup, catalytic domain
IPR009134	Tyrosine-protein kinase, vascular endothelial growth factor receptor (VEGFR), N-terminal

platelet-derived growth factor receptor, beta polypeptide

Synonym

Expression Pattern

Choropleth map on BodyParts3D

Classification in 40 Organs

Gene Information

IDs

Orthologous Gene

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

Cellular Component

Molecular Function