3-phosphoinositide dependent protein kinase-1

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Synonym

MGC20087, 3-phosphoinositide-dependent protein kinase 1, 3-phosphoinositide dependent protein kinase-1, PkB kinase, PkB-like 1, MGC35290, PDPK1, PDK1, PRO0461, PkB-like, hPDK1

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:96 cerebellum:163.70 brain stem:- corpus callosum/glia:87.50 pineal gland:- peripheral nerve:30.70 spine:- retina:118.60 eye:123.40 artery/aorta:- vein:- lymphnode:131.40 peripheral blood:91.10 spleen:37.80 thymus:103.10 bone marrow:118.10 adipose:40.30 bone:51.20 skin:100.80
GeneChip cerebrum:8.38 cerebellum:8.45 brain stem:8.34 corpus callosum/glia:8.30 pineal gland:- peripheral nerve:8.31 spine:8.26 retina:- eye:- artery/aorta:8.15 vein:8.42 lymphnode:8.26 peripheral blood:- spleen:8.43 thymus:8 bone marrow:8.32 adipose:8.23 bone:- skin:8.18
CAGE cerebrum:3.43 cerebellum:- brain stem:2.97 corpus callosum/glia:3.14 pineal gland:3.36 peripheral nerve:- spine:2.87 retina:- eye:- artery/aorta:2.98 vein:2.75 lymphnode:3.00 peripheral blood:- spleen:2.73 thymus:2.95 bone marrow:- adipose:2.60 bone:- skin:-
RNA-seq cerebrum:2.64 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:2.39 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:1.85 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:91.10 placenta:80.10 prostate:67.60 ovary:37.30 testis:151.40 heart:51.10 muscle:40.20 esophagus:- stomach:106.20 intestine:32.40 colon:195     liver/hepato:105.60        lung:73.30    bladder:- kidney:114.40 pituitary:116 thyroid/parathyroid:- adrenal gland:- pancreas:97.80 breast:46.50 salivary:-
GeneChip uterus:8.12 placenta:8.25 prostate:7.95 ovary:8.11 testis:8.17 heart:8.31 muscle:8.16 esophagus:8.32 stomach:8.39 intestine:8.28 colon:8.48 liver/hepato:8.44 lung:8.34 bladder:- kidney:8.47 pituitary:8.32 thyroid/parathyroid:8.26 adrenal gland:8.42 pancreas:8.43 breast:8.19 salivary:8.52
CAGE uterus:2.88 placenta:3.18 prostate:2.82 ovary:2.55 testis:2.88 heart:2.74 muscle:2.92 esophagus:2.70 stomach:- intestine:3.20 colon:3.05     liver/hepato:2.84    lung:2.94 bladder:2.75 kidney:2.93 pituitary:2.95 thyroid/parathyroid:2.98 adrenal gland:- pancreas:3.65 breast:3.12 salivary:3.17
RNA-seq uterus:- placenta:- prostate:2.44 ovary:2.74 testis:2.77 heart:2.60 muscle:2.60 esophagus:- stomach:- intestine:- colon:1.96     liver/hepato:1.62        lung:1.96    bladder:- kidney:2.58 pituitary:- thyroid/parathyroid:2.21 adrenal gland:1.87 pancreas:- breast:1.90 salivary:-

IDs

Refseq ID NM_002613
Gene ID 5170
Unigene ID Hs.459691
Probe set ID 32029_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000140992
GTEx ID ENSG00000140992

Orthologous Gene

Mouse[3]  NM_001080773, NM_011062
Rat [0]  

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed  (Pubmed ID)

Gene Ontology  (GO ID)

Biological Process

GO:0030036  actin cytoskeleton organization
GO:0032148  activation of protein kinase B activity
GO:0007596  blood coagulation
GO:0032869  cellular response to insulin stimulus
GO:0007173  epidermal growth factor receptor signaling pathway
GO:0008543  fibroblast growth factor receptor signaling pathway
GO:0048041  focal adhesion formation
GO:0006972  hyperosmotic response
GO:0045087  innate immune response
GO:0008286  insulin receptor signaling pathway
GO:0010667  negative regulation of cardiac muscle cell apoptosis
GO:0006469  negative regulation of protein kinase activity
GO:0034122  negative regulation of toll-like receptor signaling pathway
GO:0030512  negative regulation of transforming growth factor beta receptor signaling pathway
GO:0048011  nerve growth factor receptor signaling pathway
GO:0003323  pancreatic B cell development
GO:0018107  peptidyl-threonine phosphorylation
GO:0048015  phosphoinositide-mediated signaling
GO:0030168  platelet activation
GO:0090004  positive regulation of establishment of protein localization in plasma membrane
GO:0046777  protein amino acid autophosphorylation
GO:0006468  protein amino acid phosphorylation
GO:0010594  regulation of endothelial cell migration
GO:0043122  regulation of I-kappaB kinase/NF-kappaB cascade
GO:0043304  regulation of mast cell degranulation
GO:0006355  regulation of transcription, DNA-dependent
GO:0007268  synaptic transmission
GO:0031295  T cell costimulation
GO:0050852  T cell receptor signaling pathway
GO:0006351  transcription, DNA-dependent

Cellular Component

GO:0005737  cytoplasm
GO:0016023  cytoplasmic membrane-bounded vesicle
GO:0005829  cytosol
GO:0005925  focal adhesion
GO:0016020  membrane
GO:0005654  nucleoplasm
GO:0005886  plasma membrane

Molecular Function

GO:0004676  3-phosphoinositide-dependent protein kinase activity
GO:0005524  ATP binding
GO:0005158  insulin receptor binding
GO:0016301  kinase activity
GO:0005515  protein binding
GO:0019901  protein kinase binding
GO:0004674  protein serine/threonine kinase activity