3-phosphoinositide dependent protein kinase-1

Synonym

MGC20087, 3-phosphoinositide-dependent protein kinase 1, 3-phosphoinositide dependent protein kinase-1, PkB kinase, PkB-like 1, MGC35290, PDPK1, PDK1, PRO0461, PkB-like, hPDK1

normal 40 tissues
cell lines, primary cells, adult tissues and fetal tissues (FANTOM5 CAGE)

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain

blood

connective

EST

cerebrum:96

cerebellum:163.70

brain stem:-

corpus callosum/glia:87.50

pineal gland:-

peripheral nerve:30.70

spine:-

retina:118.60

eye:123.40

artery/aorta:-

vein:-

lymphnode:131.40

peripheral blood:91.10

spleen:37.80

thymus:103.10

bone marrow:118.10

adipose:40.30

bone:51.20

skin:100.80

GeneChip

cerebrum:8.38

cerebellum:8.45

brain stem:8.34

corpus callosum/glia:8.30

pineal gland:-

peripheral nerve:8.31

spine:8.26

retina:-

eye:-

artery/aorta:8.15

vein:8.42

lymphnode:8.26

peripheral blood:-

spleen:8.43

thymus:8

bone marrow:8.32

adipose:8.23

bone:-

skin:8.18

CAGE

cerebrum:3.43

cerebellum:-

brain stem:2.97

corpus callosum/glia:3.14

pineal gland:3.36

peripheral nerve:-

spine:2.87

retina:-

eye:-

artery/aorta:2.98

vein:2.75

lymphnode:3.00

peripheral blood:-

spleen:2.73

thymus:2.95

bone marrow:-

adipose:2.60

bone:-

skin:-

RNA-seq

cerebrum:2.46

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:2.01

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:1.22

bone:-

skin:-

reproductive

muscular

alimentary

liver

lung

urinary

endo/exo-crine

EST

uterus:91.10

placenta:80.10

prostate:67.60

ovary:37.30

testis:151.40

heart:51.10

muscle:40.20

esophagus:-

stomach:106.20

intestine:32.40

colon:195

liver/hepato:105.60

lung:73.30

bladder:-

kidney:114.40

pituitary:116

thyroid/parathyroid:-

adrenal gland:-

pancreas:97.80

breast:46.50

salivary:-

GeneChip

uterus:8.12

placenta:8.25

prostate:7.95

ovary:8.11

testis:8.17

heart:8.31

muscle:8.16

esophagus:8.32

stomach:8.39

intestine:8.28

colon:8.48

liver/hepato:8.44

lung:8.34

bladder:-

kidney:8.47

pituitary:8.32

thyroid/parathyroid:8.26

adrenal gland:8.42

pancreas:8.43

breast:8.19

salivary:8.52

CAGE

uterus:2.88

placenta:3.18

prostate:2.82

ovary:2.55

testis:2.88

heart:2.74

muscle:2.92

esophagus:2.70

stomach:-

intestine:3.20

colon:3.05

liver/hepato:2.84

lung:2.94

bladder:2.75

kidney:2.93

pituitary:2.95

thyroid/parathyroid:2.98

adrenal gland:-

pancreas:3.65

breast:3.12

salivary:3.17

RNA-seq

uterus:-

placenta:-

prostate:2.20

ovary:1.60

testis:0.58

heart:0.86

muscle:2.08

esophagus:-

stomach:-

intestine:-

colon:1.34

liver/hepato:2.05

lung:0.78

bladder:-

kidney:2.54

pituitary:-

thyroid/parathyroid:2.63

adrenal gland:1.88

pancreas:-

breast:1.55

salivary:-

IDs

Refseq ID	NM_031268
Gene ID	5170
Unigene ID	Hs.459691
Probe set ID	32029_at [HG-U133_Plus_2]
Ensembl ID	ENSG00000140992
GTEx ID	ENSG00000140992

Orthologous Gene

Mouse[3]	NM_001080773, NM_011062
Rat [0]

Chromosomal Region

16p13.3 [2,587,965 - 2,653,189]

Search genes near this gene
- Between -5kb and +5kb
- Between -10kb and +10kb

Gene Family (Interpro ID)

IPR000719	Protein kinase, catalytic domain
IPR011009	Protein kinase-like domain
IPR002290	Serine/threonine-protein kinase domain
IPR017442	Serine/threonine-protein kinase-like domain
IPR001245	Tyrosine-protein kinase, catalytic domain
IPR020635	Tyrosine-protein kinase, subgroup, catalytic domain

Gene Ontology (GO ID)

Biological Process

GO:0030036	actin cytoskeleton organization
GO:0032148	activation of protein kinase B activity
GO:0007596	blood coagulation
GO:0032869	cellular response to insulin stimulus
GO:0007173	epidermal growth factor receptor signaling pathway
GO:0008543	fibroblast growth factor receptor signaling pathway
GO:0048041	focal adhesion formation
GO:0006972	hyperosmotic response
GO:0045087	innate immune response
GO:0008286	insulin receptor signaling pathway
GO:0010667	negative regulation of cardiac muscle cell apoptosis
GO:0006469	negative regulation of protein kinase activity
GO:0034122	negative regulation of toll-like receptor signaling pathway
GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway
GO:0048011	nerve growth factor receptor signaling pathway
GO:0003323	pancreatic B cell development
GO:0018107	peptidyl-threonine phosphorylation
GO:0048015	phosphoinositide-mediated signaling
GO:0030168	platelet activation
GO:0090004	positive regulation of establishment of protein localization in plasma membrane
GO:0046777	protein amino acid autophosphorylation
GO:0006468	protein amino acid phosphorylation
GO:0010594	regulation of endothelial cell migration
GO:0043122	regulation of I-kappaB kinase/NF-kappaB cascade
GO:0043304	regulation of mast cell degranulation
GO:0006355	regulation of transcription, DNA-dependent
GO:0007268	synaptic transmission
GO:0031295	T cell costimulation
GO:0050852	T cell receptor signaling pathway
GO:0006351	transcription, DNA-dependent

Cellular Component

GO:0005737	cytoplasm
GO:0016023	cytoplasmic membrane-bounded vesicle
GO:0005829	cytosol
GO:0005925	focal adhesion
GO:0016020	membrane
GO:0005654	nucleoplasm
GO:0005886	plasma membrane

Molecular Function

GO:0004676	3-phosphoinositide-dependent protein kinase activity
GO:0005524	ATP binding
GO:0005158	insulin receptor binding
GO:0016301	kinase activity
GO:0005515	protein binding
GO:0019901	protein kinase binding
GO:0004674	protein serine/threonine kinase activity

3-phosphoinositide dependent protein kinase-1

Synonym

Expression Pattern

Choropleth map on BodyParts3D

Classification in 40 Organs

Gene Information

IDs

Orthologous Gene

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

Cellular Component

Molecular Function