SIX homeobox 4

 jump to detail

Synonym

SIX4, MGC119452, MGC119453, sine oculis homeobox homolog 4 (Drosophila), Sine oculis homeobox homolog 4, AREC3, MGC119450, sine oculis homeobox (Drosophila) homolog 4, Homeobox protein SIX4

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:- cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:30.70 spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:12.90 bone marrow:19.70 adipose:- bone:- skin:9.60
GeneChip nodata
CAGE cerebrum:0.81 cerebellum:- brain stem:1.02 corpus callosum/glia:0.47 pineal gland:0.47 peripheral nerve:- spine:0.82 retina:- eye:- artery/aorta:1.91 vein:1.10 lymphnode:0.52 peripheral blood:- spleen:0 thymus:0.71 bone marrow:- adipose:1.16 bone:- skin:-
RNA-seq cerebrum:0.37 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:0.56 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0.44 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:7.30 prostate:11.30 ovary:- testis:- heart:- muscle:20.10 esophagus:- stomach:- intestine:- colon:8.50     liver/hepato:10.60        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:18.60 salivary:-
GeneChip nodata
CAGE uterus:0.99 placenta:1.17 prostate:1.59 ovary:1.44 testis:0.48 heart:0.81 muscle:2.57 esophagus:0.68 stomach:- intestine:0.27 colon:0.36     liver/hepato:0.14    lung:1.29 bladder:1.09 kidney:0.44 pituitary:1.96 thyroid/parathyroid:1.56 adrenal gland:- pancreas:1.42 breast:1.80 salivary:2.88
RNA-seq uterus:- placenta:- prostate:0.93 ovary:1.20 testis:0.75 heart:0.31 muscle:3.81 esophagus:- stomach:- intestine:- colon:0.37     liver/hepato:0.15        lung:1.73    bladder:- kidney:0.88 pituitary:- thyroid/parathyroid:1.38 adrenal gland:0.10 pancreas:- breast:0.80 salivary:-

Gene Information

IDs

Refseq ID NM_017420
Gene ID 51804
Unigene ID Hs.97849
Probe set ID -
Ensembl ID ENSG00000100625
GTEx ID ENSG00000100625

Orthologous Gene

Mouse[2]  NM_011382
Rat[1]  NM_001106739

Chromosomal Region

14q23.1  [61,176,246  -  61,191,066]

Gene Family (Interpro ID)

IPR001356  Homeobox
IPR009057  Homeodomain-like
IPR012287  Homeodomain-related

Link to Pubmed  (Pubmed ID)

8628654
10490620
10512683
10640827
10906137
12215533
12441302
12477932
15489334
19471022
21693764
22939629

Gene Ontology  (GO ID)

Biological Process

GO:0009653  anatomical structure morphogenesis
GO:0048701  embryonic cranial skeleton morphogenesis
GO:0048699  generation of neurons
GO:0042472  inner ear morphogenesis
GO:0051451  myoblast migration
GO:0043524  negative regulation of neuron apoptosis
GO:0090190  positive regulation of branching involved in ureteric bud morphogenesis
GO:0045944  positive regulation of transcription from RNA polymerase II promoter
GO:0032880  regulation of protein localization
GO:0008582  regulation of synaptic growth at neuromuscular junction
GO:0007519  skeletal muscle tissue development
GO:0048538  thymus development

Cellular Component

GO:0005634  nucleus

Molecular Function

GO:0043565  sequence-specific DNA binding
GO:0003700  transcription factor activity