serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2

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Synonym

nexin, SERPINE2, GDN, Protease inhibitor 7, Protease nexin I, PNI, Glia-derived nexin precursor, PN1, PN-1, PI7

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:132.70 cerebellum:50.40 brain stem:- corpus callosum/glia:29.20 pineal gland:- peripheral nerve:122.70 spine:224.60 retina:- eye:47 artery/aorta:60 vein:- lymphnode:- peripheral blood:18.20 spleen:18.90 thymus:64.40 bone marrow:196.80 adipose:- bone:345.50 skin:96
GeneChip cerebrum:9.33 cerebellum:8.62 brain stem:9.23 corpus callosum/glia:9.17 pineal gland:- peripheral nerve:9.87 spine:9.84 retina:- eye:- artery/aorta:7.95 vein:8 lymphnode:7.36 peripheral blood:- spleen:7.98 thymus:6.77 bone marrow:5.85 adipose:6.76 bone:- skin:6.93
CAGE cerebrum:4.74 cerebellum:- brain stem:4.52 corpus callosum/glia:4.51 pineal gland:2.86 peripheral nerve:- spine:5.07 retina:- eye:- artery/aorta:3.91 vein:3.18 lymphnode:3.29 peripheral blood:- spleen:3.33 thymus:2.66 bone marrow:- adipose:2.86 bone:- skin:-
RNA-seq cerebrum:0.00 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:0.00 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0.00 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:145.80 placenta:364.30 prostate:11.30 ovary:37.30 testis:99.50 heart:89.40 muscle:20.10 esophagus:342.80 stomach:21.20 intestine:32.40 colon:50.90     liver/hepato:21.10        lung:29.30    bladder:- kidney:135.20 pituitary:- thyroid/parathyroid:- adrenal gland:50.80 pancreas:26.70 breast:46.50 salivary:-
GeneChip uterus:7.19 placenta:11.44 prostate:6.46 ovary:8.46 testis:8.96 heart:7.92 muscle:5.79 esophagus:7.57 stomach:7.37 intestine:7.98 colon:7.28 liver/hepato:6.01 lung:6.44 bladder:- kidney:8 pituitary:6.74 thyroid/parathyroid:7.70 adrenal gland:6.71 pancreas:6.75 breast:7.37 salivary:5.76
CAGE uterus:3.27 placenta:6.73 prostate:3.29 ovary:4.74 testis:4.28 heart:4.90 muscle:1.63 esophagus:4.15 stomach:- intestine:3.31 colon:2.82     liver/hepato:1.95    lung:2.22 bladder:4.45 kidney:3.89 pituitary:1.74 thyroid/parathyroid:3.09 adrenal gland:- pancreas:2.34 breast:3.78 salivary:1.58
RNA-seq uterus:- placenta:- prostate:0.58 ovary:3.66 testis:3.31 heart:0.80 muscle:0.00 esophagus:- stomach:- intestine:- colon:1.74     liver/hepato:0.00        lung:0.00    bladder:- kidney:2.58 pituitary:- thyroid/parathyroid:0.92 adrenal gland:2.09 pancreas:- breast:0.00 salivary:-

Gene Information

IDs

Refseq ID NM_006216
Gene ID 5270
Unigene ID Hs.38449
Probe set ID 212190_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000135919
GTEx ID ENSG00000135919

Orthologous Gene

Mouse[1]  NM_009255
Rat[1]  NM_019197

Chromosomal Region

2q36.1  [224,839,829  -  224,904,036]

Gene Family (Interpro ID)

-

Link to Pubmed  (Pubmed ID)

1334458
1691280
1939253
2037625
2877744
3279057
3427015
3997857
7665170
8006028
8125298
9184208
11827452
11925594
12106474
12356769
12477932
12859287
15340161
15489334
16015279
16085935
16344560
16358219
16741952
16921128
17379830
17446335
17690329
17703087
17934860
18550614
18617644
19017876
19111454
19249338
19322201
19439404
19584287
19604412
19626039
19789190
19855083
19911255
19949669
20035713
20233420
20298363
20463177
20525719
20623540
20805453
20819545
20881960
20942929
21067581
21403095
21426587
21436250
21611750
21806836
22028159
22145704
22331468
22618708
22863883
23041623
23385179
23648065
23661674
24023701
24172014

Gene Ontology  (GO ID)

Biological Process

GO:0007596  blood coagulation
GO:0021683  cerebellar granular layer morphogenesis
GO:0050974  detection of mechanical stimulus involved in sensory perception
GO:0060384  innervation
GO:0060291  long-term synaptic potentiation
GO:0042628  mating plug formation
GO:0030195  negative regulation of blood coagulation
GO:0030308  negative regulation of cell growth
GO:0008285  negative regulation of cell proliferation
GO:0010951  negative regulation of endopeptidase activity
GO:0014067  negative regulation of phosphoinositide 3-kinase cascade
GO:0010757  negative regulation of plasminogen activation
GO:0010544  negative regulation of platelet activation
GO:0042177  negative regulation of protein catabolic process
GO:0010955  negative regulation of protein maturation by peptide bond cleavage
GO:0045861  negative regulation of proteolysis
GO:0045879  negative regulation of smoothened signaling pathway
GO:0010766  negative regulation of sodium ion transport
GO:0048711  positive regulation of astrocyte differentiation
GO:0030334  regulation of cell migration
GO:0051966  regulation of synaptic transmission, glutamatergic
GO:0048505  regulation of timing of cell differentiation
GO:0032940  secretion by cell
GO:0033363  secretory granule organization

Cellular Component

GO:0005829  cytosol
GO:0031012  extracellular matrix
GO:0005576  extracellular region
GO:0005615  extracellular space
GO:0031232  extrinsic to external side of plasma membrane
GO:0031594  neuromuscular junction
GO:0031091  platelet alpha granule

Molecular Function

GO:0005539  glycosaminoglycan binding
GO:0008201  heparin binding
GO:0005515  protein binding
GO:0005102  receptor binding
GO:0004867  serine-type endopeptidase inhibitor activity