phosphoinositide-3-kinase, catalytic, beta polypeptide

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Synonym

PI3-kinase p110 subunit beta, MGC133043, p110-BETA, PI3Kbeta, PIK3CB, PIK3C1, DKFZp779K1237

normal 40 tissues
cell lines, primary cells, adult tissues and fetal tissues (FANTOM5 CAGE)

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain

blood

connective

EST

cerebrum:51

cerebellum:25.20

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:61.30

spine:-

retina:-

eye:17.60

artery/aorta:60

vein:66.60

lymphnode:40.40

peripheral blood:18.20

spleen:-

thymus:-

bone marrow:157.40

adipose:-

bone:25.60

skin:96

GeneChip

cerebrum:6.88

cerebellum:6.83

brain stem:7.02

corpus callosum/glia:6.04

pineal gland:-

peripheral nerve:6.10

spine:6.60

retina:-

eye:-

artery/aorta:5.84

vein:5.39

lymphnode:5.68

peripheral blood:-

spleen:5.34

thymus:6.23

bone marrow:6.94

adipose:5.96

bone:-

skin:6.48

CAGE

cerebrum:3.56

cerebellum:-

brain stem:3.72

corpus callosum/glia:3.41

pineal gland:3.24

peripheral nerve:-

spine:3.33

retina:-

eye:-

artery/aorta:2.94

vein:3.15

lymphnode:3.08

peripheral blood:-

spleen:3.17

thymus:3.41

bone marrow:-

adipose:3.20

bone:-

skin:-

RNA-seq

cerebrum:3.69

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:2.40

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:3.13

bone:-

skin:-

reproductive

muscular

alimentary

liver

lung

urinary

endo/exo-crine

EST

uterus:18.20

placenta:25.50

prostate:33.80

ovary:37.30

testis:17.30

heart:-

muscle:20.10

esophagus:-

stomach:21.20

intestine:32.40

colon:76.30

liver/hepato:21.10

lung:19.60

bladder:-

kidney:62.40

pituitary:-

thyroid/parathyroid:-

adrenal gland:-

pancreas:35.60

breast:46.50

salivary:-

GeneChip

uterus:5.61

placenta:7.09

prostate:6.81

ovary:5.99

testis:5.44

heart:5.79

muscle:6.45

esophagus:6.21

stomach:5.61

intestine:6.02

colon:5.38

liver/hepato:5.29

lung:5.88

bladder:-

kidney:6.63

pituitary:5.43

thyroid/parathyroid:7.13

adrenal gland:5.30

pancreas:6.05

breast:6.27

salivary:6.37

CAGE

uterus:3.21

placenta:3.72

prostate:3.07

ovary:2.81

testis:2.70

heart:3.09

muscle:3.16

esophagus:3.21

stomach:-

intestine:3.70

colon:3.32

liver/hepato:2.91

lung:3.16

bladder:3.18

kidney:3.49

pituitary:3.02

thyroid/parathyroid:3.81

adrenal gland:-

pancreas:3.61

breast:2.41

salivary:3.77

RNA-seq

uterus:-

placenta:-

prostate:3.08

ovary:2.52

testis:2.85

heart:3.14

muscle:3.12

esophagus:-

stomach:-

intestine:-

colon:2.95

liver/hepato:2.08

lung:2.36

bladder:-

kidney:3.41

pituitary:-

thyroid/parathyroid:3.72

adrenal gland:1.93

pancreas:-

breast:3.20

salivary:-

IDs

Refseq ID	NM_006219
Gene ID	5291
Unigene ID	Hs.239818
Probe set ID	212688_at [HG-U133_Plus_2]
Ensembl ID	ENSG00000051382
GTEx ID	ENSG00000051382

Orthologous Gene

Mouse[1]	NM_029094
Rat [0]

Chromosomal Region

3q22.3 [138,372,860 - 138,553,780]

Search genes near this gene
- Between -5kb and +5kb
- Between -10kb and +10kb

Gene Family (Interpro ID)

IPR016024	Armadillo-type fold
IPR008973	C2 calcium/lipid-binding domain, CaLB
IPR000403	Phosphatidylinositol 3-/4-kinase, catalytic
IPR001263	Phosphoinositide 3-kinase, accessory (PIK) domain
IPR002420	Phosphoinositide 3-kinase, C2
IPR011009	Protein kinase-like domain

Gene Ontology (GO ID)

Biological Process

GO:0000187	activation of MAPK activity
GO:0006914	autophagy
GO:0007596	blood coagulation
GO:0016477	cell migration
GO:0006874	cellular calcium ion homeostasis
GO:0006935	chemotaxis
GO:0040016	embryonic cleavage
GO:0007173	epidermal growth factor receptor signaling pathway
GO:0008543	fibroblast growth factor receptor signaling pathway
GO:0007186	G-protein coupled receptor protein signaling pathway
GO:0007156	homophilic cell adhesion
GO:0045087	innate immune response
GO:0008286	insulin receptor signaling pathway
GO:0050900	leukocyte migration
GO:0048011	nerve growth factor receptor signaling pathway
GO:0006661	phosphatidylinositol biosynthetic process
GO:0014065	phosphoinositide 3-kinase cascade
GO:0048015	phosphoinositide-mediated signaling
GO:0006644	phospholipid metabolic process
GO:0030168	platelet activation
GO:0070527	platelet aggregation
GO:0010508	positive regulation of autophagy
GO:0001952	regulation of cell-matrix adhesion
GO:0007165	signal transduction
GO:0050852	T cell receptor signaling pathway
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway

Cellular Component

GO:0005829	cytosol
GO:0005634	nucleus
GO:0005942	phosphoinositide 3-kinase complex
GO:0005886	plasma membrane

Molecular Function

GO:0016303	1-phosphatidylinositol-3-kinase activity
GO:0005524	ATP binding
GO:0043560	insulin receptor substrate binding
GO:0046934	phosphatidylinositol-4,5-bisphosphate 3-kinase activity
GO:0035005	phosphatidylinositol-4-phosphate 3-kinase activity
GO:0035004	phosphoinositide 3-kinase activity
GO:0005515	protein binding

phosphoinositide-3-kinase, catalytic, beta polypeptide

Synonym

Expression Pattern

Choropleth map on BodyParts3D

Classification in 40 Organs

Gene Information

IDs

Orthologous Gene

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

Cellular Component

Molecular Function