phosphoinositide-3-kinase, regulatory subunit 1 (alpha)

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Synonym

p85-ALPHA, GRB1, PIK3R1, PI3-kinase p85-subunit alpha, PI3K p85, PtdIns-3-kinase p85-alpha

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:282.10 cerebellum:37.80 brain stem:- corpus callosum/glia:- pineal gland:296.70 peripheral nerve:92 spine:224.60 retina:- eye:129.30 artery/aorta:30 vein:- lymphnode:111.20 peripheral blood:72.90 spleen:113.40 thymus:77.30 bone marrow:59 adipose:201.70 bone:76.80 skin:52.80
GeneChip cerebrum:8.34 cerebellum:7.44 brain stem:8.07 corpus callosum/glia:7.79 pineal gland:- peripheral nerve:8.67 spine:7.65 retina:- eye:- artery/aorta:8.01 vein:7.43 lymphnode:7.13 peripheral blood:- spleen:8.10 thymus:8.16 bone marrow:6.50 adipose:7.90 bone:- skin:8.02
CAGE cerebrum:5.07 cerebellum:- brain stem:4.97 corpus callosum/glia:4.54 pineal gland:5.33 peripheral nerve:- spine:4.93 retina:- eye:- artery/aorta:4.42 vein:4.76 lymphnode:3.99 peripheral blood:- spleen:4.86 thymus:4.56 bone marrow:- adipose:5.19 bone:- skin:-
RNA-seq cerebrum:3.66 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:2.82 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:3.66 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:100.20 placenta:21.90 prostate:112.60 ovary:37.30 testis:8.70 heart:166 muscle:60.30 esophagus:- stomach:21.20 intestine:- colon:50.90     liver/hepato:105.60        lung:63.50    bladder:125.60 kidney:62.40 pituitary:116 thyroid/parathyroid:- adrenal gland:50.80 pancreas:106.70 breast:74.30 salivary:-
GeneChip uterus:8.70 placenta:7.01 prostate:8.37 ovary:8.08 testis:5.87 heart:8.26 muscle:6.56 esophagus:7.07 stomach:7.11 intestine:7.23 colon:6.91 liver/hepato:8.58 lung:7.69 bladder:- kidney:6.40 pituitary:6.76 thyroid/parathyroid:7.02 adrenal gland:7.15 pancreas:5.51 breast:8.72 salivary:7.82
CAGE uterus:5.13 placenta:4.37 prostate:4.74 ovary:4.55 testis:3.82 heart:4.57 muscle:5.23 esophagus:4.89 stomach:- intestine:4.54 colon:4.39     liver/hepato:4.70    lung:4.76 bladder:5.15 kidney:4.79 pituitary:3.97 thyroid/parathyroid:3.88 adrenal gland:- pancreas:3.10 breast:5.41 salivary:4.78
RNA-seq uterus:- placenta:- prostate:3.49 ovary:3.01 testis:3.02 heart:5.09 muscle:3.39 esophagus:- stomach:- intestine:- colon:3.64     liver/hepato:3.07        lung:2.89    bladder:- kidney:2.37 pituitary:- thyroid/parathyroid:3.98 adrenal gland:2.32 pancreas:- breast:2.79 salivary:-

IDs

Refseq ID NM_181523
Gene ID 5295
Unigene ID Hs.132225
Probe set ID 212239_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000145675
GTEx ID ENSG00000145675

Orthologous Gene

Mouse[6]  NM_001024955, NM_001077495
Rat [0]  

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed  (Pubmed ID)

1314371
1336372
1351056
1372092
1381348
1383690
1648445
1849461
2174051
7504174
7509796
7513258
7522165
7528218
7537265
7537275
7537361
7537362
7537849
7541045
7559499
7592789
7629060
7642542
7642581
7657594
7662955
7681364
7689147
7689724
7737275
7737969
7759531
7782332
7791764
7807015
7876130
7929193
7982920
8034624
8052599
8084603
8125298
8139559
8175658
8246987
8253717
8276809
8294442
8313897
8384556
8385099
8388538
8394019
8440175
8596638
8599763
8603569
8612729
8621607
8621719
8628286
8631888
8636073
8647200
8648629
8649427
8662998
8670861
8695807
8697095
8702385
8702949
8702998
8766817
8798481
8805332
8810341
8896416
8910607
8916957
8918464
8918688
8941725
8947469
8961927
8962058
8995243
9032108
9079809
9092538
9113989
9123823
9130710
9139718
9150145
9162069
9174058
9178760
9178903
9223670
9233773
9234717
9247029
9259313
9268059
9312149
9334184
9341793
9356464
9360994
9361008
9381982
9394803
9414268
9435577
9446654
9446795
9461587
9461588
9489702
9541596
9564850
9610355
9614102
9632636
9658397
9687533
9708406
9756944
9774384
9774657
9801792
9804835
9808187
9852124
9886492
9890943
9891995
9892650
9918857
9988765
10022120
10022833
10025673
10068651
10086340
10097090
10187839
10208934
10212255
10339567
10358153
10358157
10358777
10358930
10373529
10377409
10383151
10422873
10426994
10437794
10455176
10459020
10467411
10477752
10487518
10500481
10521483
10527852
10542297
10572067
10579793
10620516
10627473
10648629
10652352
10697503
10723796
10768093
10797305
10799562
10806474
10871282
10899172
10918571
10921882
10962563
10967104
10970851
10985305
10995743
11029009
11030146
11042121
11071635
11071869
11087752
11094073
11133830
11136977
11154208
11156964
11157475
11160222
11163197
11278378
11287610
11289809
11313349
11334882
11337495
11341978
11368773
11375989
11418612
11431473
11445578
11526404
11546794
11567151
11604231
11606067
11689445
11689561
11689886
11711534
11716761
11739737
11741599
11782427
11812000
11842213
11850823
11855827
11865050
11912194
11940581
11944898
11986952
11994280
11994282
12009866
12029088
12052866
12074588
12077252
12086876
12107746
12112020
12167717
12173038
12185156
12186904
12210743
12220227
12359715
12393736
12397383
12454018
12470648
12477932
12526811
12529960
12538575
12538664
12551992
12582030
12584329
12588990
12594831
12621049
12637493
12644569
12660731
12668683
12704201
12714585
12730242
12734410
12774123
12783867
12878163
12933816
12960231
14511371
14530346
14551916
14597629
14602571
14699157
14702039
14729945
14769856
14965316
14968112
15007072
15016818
15107835
15117958
15127203
15192701
15324660
15351743
15377662
15388330
15476827
15488758
15489334
15490304
15502848
15514089
15536084
15556646
15629149
15638726
15644415
15689238
15735664
15741161
15809724
15826941
15872086
15910625
15932879
15951569
16007092
16043515
16081599
16135792
16168140
16219545
16228294
16230374
16273093
16289966
16306077
16344560
16354680
16377635
16412560
16491394
16524887
16638574
16644730
16717100
16787925
16843263
16844778
16917505
16921024
16964398
16982329
17006756
17013094
17016694
17038539
17157319
17207965
17214991
17237826
17242350
17242406
17302605
17404186
17437541
17442886
17452978
17474147
17486587
17570359
17626883
17632516
17632570
17827393
17890432
18029348
18079394
18227218
18245521
18249389
18328427
18335044
18372911
18374639
18387942
18418043
18453587
18534979
18606683
18624398
18660489
18711014
18854243
18974049
18990689
18996102
19190244
19218574
19286672
19304514
19336760
19351817
19380743
19454690
19482007
19531499
19561084
19578796
19634059
19635806
19639178
19640849
19747165
19807924
19861161
19885597
19903481
19903888
19913121
19946888
19962665
20018188
20019835
20056178
20086096
20212113
20237496
20379614
20407443
20457601
20501401
20530665
20598684
20602615
20628086
20702582
20713702
20714879
20800603
20818790
20846792
20936779
21029719
21057544
21077741
21113646
21139048
21145461
21200133
21203488
21241768
21362552
21430300
21478295
21487925
21533174
21701776
21706016
21743495
21765914
21984976
21988832
22027828
22064833
22120714
22271581
22355357
22558309
22684007
22728334
22745667
22752602
22939629
22974441
23166678
23215766
23221569
23251686
23275563
23301033
23419831
23562842
23569237
23583404
23599027
23603894
23604317
23810378
23810379
23810382
23980150
24004856
24073214
24113870
24229379
24657164
24830046

Gene Ontology  (GO ID)

Biological Process

GO:0030183  B cell differentiation
GO:0007596  blood coagulation
GO:0034644  cellular response to UV
GO:0007173  epidermal growth factor receptor signaling pathway
GO:0008543  fibroblast growth factor receptor signaling pathway
GO:0060396  growth hormone receptor signaling pathway
GO:0045087  innate immune response
GO:0008286  insulin receptor signaling pathway
GO:0048009  insulin-like growth factor receptor signaling pathway
GO:0050900  leukocyte migration
GO:0043066  negative regulation of apoptosis
GO:0001953  negative regulation of cell-matrix adhesion
GO:0045671  negative regulation of osteoclast differentiation
GO:0048011  nerve growth factor receptor signaling pathway
GO:0051531  NFAT protein import into nucleus
GO:0006661  phosphatidylinositol biosynthetic process
GO:0014065  phosphoinositide 3-kinase cascade
GO:0046854  phosphoinositide phosphorylation
GO:0048015  phosphoinositide-mediated signaling
GO:0006644  phospholipid metabolic process
GO:0030168  platelet activation
GO:0043065  positive regulation of apoptosis
GO:0030335  positive regulation of cell migration
GO:0090004  positive regulation of establishment of protein localization in plasma membrane
GO:0046326  positive regulation of glucose import
GO:0045944  positive regulation of transcription from RNA polymerase II promoter
GO:0006468  protein amino acid phosphorylation
GO:0043551  regulation of phosphoinositide 3-kinase activity
GO:0031295  T cell costimulation
GO:0050852  T cell receptor signaling pathway
GO:0019048  virus-host interaction

Cellular Component

GO:0005943  1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex
GO:0005829  cytosol
GO:0005942  phosphoinositide 3-kinase complex
GO:0005886  plasma membrane

Molecular Function

GO:0043125  ErbB-3 class receptor binding
GO:0043559  insulin binding
GO:0005158  insulin receptor binding
GO:0043560  insulin receptor substrate binding
GO:0005159  insulin-like growth factor receptor binding
GO:0005168  neurotrophin TRKA receptor binding
GO:0005545  phosphatidylinositol binding
GO:0043548  phosphoinositide 3-kinase binding
GO:0035014  phosphoinositide 3-kinase regulator activity
GO:0005515  protein binding
GO:0019903  protein phosphatase binding
GO:0005068  transmembrane receptor protein tyrosine kinase adaptor protein activity