phosphatidylinositol 4-kinase, catalytic, alpha

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Synonym

PI4K-alpha, PI4-kinase alpha, PIK4, PtdIns-4-kinase alpha, FLJ16556, pi4K230, PI4K-ALPHA, PIK4CA, Phosphatidylinositol 4-kinase alpha

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:209.80 cerebellum:163.70 brain stem:- corpus callosum/glia:- pineal gland:148.30 peripheral nerve:61.30 spine:- retina:- eye:64.60 artery/aorta:30 vein:- lymphnode:91 peripheral blood:18.20 spleen:56.70 thymus:116 bone marrow:157.40 adipose:201.70 bone:25.60 skin:67.20
GeneChip cerebrum:7.99 cerebellum:7.88 brain stem:7.42 corpus callosum/glia:6.56 pineal gland:- peripheral nerve:7.62 spine:6.78 retina:- eye:- artery/aorta:6.69 vein:5.97 lymphnode:7.11 peripheral blood:- spleen:6.99 thymus:7.80 bone marrow:6.26 adipose:6.54 bone:- skin:6.34
CAGE cerebrum:4.56 cerebellum:- brain stem:4.06 corpus callosum/glia:3.98 pineal gland:4.10 peripheral nerve:- spine:3.62 retina:- eye:- artery/aorta:3.53 vein:3.61 lymphnode:3.45 peripheral blood:- spleen:3.35 thymus:4.31 bone marrow:- adipose:3.47 bone:- skin:-
RNA-seq cerebrum:3.50 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:3.14 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:2.30 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:91.10 placenta:58.30 prostate:101.40 ovary:37.30 testis:151.40 heart:166 muscle:40.20 esophagus:- stomach:63.70 intestine:- colon:110.20     liver/hepato:31.70        lung:63.50    bladder:125.60 kidney:41.60 pituitary:- thyroid/parathyroid:- adrenal gland:50.80 pancreas:44.50 breast:74.30 salivary:-
GeneChip uterus:6.64 placenta:6.99 prostate:7.09 ovary:6.37 testis:7.69 heart:5.92 muscle:5.68 esophagus:6.43 stomach:6.42 intestine:6 colon:6.24 liver/hepato:6.35 lung:6.55 bladder:- kidney:6.64 pituitary:7.64 thyroid/parathyroid:6.93 adrenal gland:6.46 pancreas:5.08 breast:6.63 salivary:6.12
CAGE uterus:3.63 placenta:3.80 prostate:3.25 ovary:3.41 testis:3.85 heart:3.08 muscle:2.58 esophagus:3.21 stomach:- intestine:3.55 colon:3.54     liver/hepato:3.42    lung:3.32 bladder:3.12 kidney:3.31 pituitary:3.92 thyroid/parathyroid:3.17 adrenal gland:- pancreas:2.66 breast:3.62 salivary:3.38
RNA-seq uterus:- placenta:- prostate:2.86 ovary:2.45 testis:3.43 heart:0.35 muscle:2.40 esophagus:- stomach:- intestine:- colon:2.35     liver/hepato:2.57        lung:2.39    bladder:- kidney:2.79 pituitary:- thyroid/parathyroid:2.35 adrenal gland:3.01 pancreas:- breast:2.20 salivary:-

Gene Information

IDs

Refseq ID NM_002650
Gene ID 5297
Unigene ID Hs.529438
Probe set ID 207081_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000241973
GTEx ID ENSG00000241973

Orthologous Gene

Mouse[1]  NM_001001983
Rat [0]  

Chromosomal Region

22q11.21  [21,061,979  -  21,213,705]

Gene Family (Interpro ID)

IPR016024  Armadillo-type fold
IPR000403  Phosphatidylinositol 3-/4-kinase, catalytic
IPR001263  Phosphoinositide 3-kinase, accessory (PIK) domain
IPR011009  Protein kinase-like domain

Link to Pubmed  (Pubmed ID)

1318025
7761838
7961848
8246987
8662589
8889548
9360995
9654085
10101268
11907035
12477932
12497619
12594831
14676841
14702039
15489334
15607035
15634669
16169070
16344560
16606619
17131383
17215244
17555516
17893707
18077555
18521859
18585705
18615484
18646052
18976975
19304308
19605471
19608626
19738201
19913121
19946888
20052689
20530568
20628086
21139048
21238945
21297162
21330372
21601653
21697487
21890473
21900206
21906983
21963094
22022594
22535966
22623428
22896614
22939629
23000965
23675303
24077433
24250222
24415756

Gene Ontology  (GO ID)

Biological Process

GO:0006661  phosphatidylinositol biosynthetic process
GO:0048015  phosphoinositide-mediated signaling
GO:0006644  phospholipid metabolic process
GO:0007165  signal transduction
GO:0007268  synaptic transmission

Cellular Component

GO:0005829  cytosol
GO:0005798  Golgi-associated vesicle
GO:0005886  plasma membrane

Molecular Function

GO:0004430  1-phosphatidylinositol 4-kinase activity
GO:0005524  ATP binding
GO:0005515  protein binding