polycystic kidney disease 2 (autosomal dominant)

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Synonym

Polycystwin, Polycystin-2, PKD4, PKD2, Polycystic kidney disease 2 protein homolog, polycystic kidney disease 2 (autosomal dominant), APKD2, R48321, MGC138468, MGC138466

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:26.10 cerebellum:- brain stem:- corpus callosum/glia:29.20 pineal gland:- peripheral nerve:92 spine:- retina:- eye:41.10 artery/aorta:89.90 vein:66.60 lymphnode:70.80 peripheral blood:- spleen:- thymus:12.90 bone marrow:19.70 adipose:- bone:25.60 skin:48
GeneChip cerebrum:5.73 cerebellum:5.72 brain stem:5.78 corpus callosum/glia:6.57 pineal gland:- peripheral nerve:6.95 spine:6.21 retina:- eye:- artery/aorta:7.99 vein:7.35 lymphnode:6 peripheral blood:- spleen:5.72 thymus:6.05 bone marrow:5.40 adipose:7.32 bone:- skin:6.08
CAGE cerebrum:2.52 cerebellum:- brain stem:2.84 corpus callosum/glia:3.17 pineal gland:2.84 peripheral nerve:- spine:2.56 retina:- eye:- artery/aorta:4.82 vein:2.83 lymphnode:1.68 peripheral blood:- spleen:1.86 thymus:2.11 bone marrow:- adipose:3.23 bone:- skin:-
RNA-seq cerebrum:2.48 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:3.94 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:3.37 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:136.70 placenta:14.60 prostate:56.30 ovary:74.50 testis:13 heart:38.30 muscle:20.10 esophagus:342.80 stomach:21.20 intestine:- colon:33.90     liver/hepato:42.20        lung:73.30    bladder:- kidney:52 pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:142.30 breast:74.30 salivary:-
GeneChip uterus:7.99 placenta:6.57 prostate:6.73 ovary:8.04 testis:5.50 heart:6.70 muscle:4.85 esophagus:5.85 stomach:6.74 intestine:6.42 colon:5.35 liver/hepato:5.69 lung:7.15 bladder:- kidney:7.51 pituitary:5.80 thyroid/parathyroid:6.73 adrenal gland:7.02 pancreas:5.79 breast:6.74 salivary:5.15
CAGE uterus:3.84 placenta:2.71 prostate:3.24 ovary:3.30 testis:2.42 heart:3.03 muscle:1.91 esophagus:3.08 stomach:- intestine:2.50 colon:2.88     liver/hepato:1.69    lung:2.92 bladder:3.02 kidney:3.07 pituitary:2.49 thyroid/parathyroid:2.45 adrenal gland:- pancreas:2.48 breast:3.12 salivary:1.67
RNA-seq uterus:- placenta:- prostate:4.16 ovary:4.38 testis:3.80 heart:2.71 muscle:1.28 esophagus:- stomach:- intestine:- colon:4.24     liver/hepato:1.39        lung:3.92    bladder:- kidney:4.47 pituitary:- thyroid/parathyroid:3.29 adrenal gland:3.12 pancreas:- breast:3.92 salivary:-

IDs

Refseq ID NM_000297
Gene ID 5311
Unigene ID Hs.181272
Probe set ID 203688_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000118762
GTEx ID ENSG00000118762

Orthologous Gene

Mouse[1]  NM_008861
Rat [0]  

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed  (Pubmed ID)

Gene Ontology  (GO ID)

Biological Process

GO:0001658  branching involved in ureteric bud morphogenesis
GO:0070588  calcium ion transmembrane transport
GO:0006816  calcium ion transport
GO:0007050  cell cycle arrest
GO:0071498  cellular response to fluid shear stress
GO:0071464  cellular response to hydrostatic pressure
GO:0071470  cellular response to osmotic stress
GO:0034614  cellular response to reactive oxygen species
GO:0051298  centrosome duplication
GO:0042994  cytoplasmic sequestering of transcription factor
GO:0050982  detection of mechanical stimulus
GO:0003127  detection of nodal flow
GO:0007368  determination of left/right symmetry
GO:0001892  embryonic placenta development
GO:0007507  heart development
GO:0001947  heart looping
GO:0007259  JAK-STAT cascade
GO:0001889  liver development
GO:0008285  negative regulation of cell proliferation
GO:0060315  negative regulation of ryanodine-sensitive calcium-release channel activity
GO:0021915  neural tube development
GO:0060674  placenta blood vessel development
GO:0071158  positive regulation of cell cycle arrest
GO:0031659  positive regulation of cyclin-dependent protein kinase activity during G1/S
GO:0031587  positive regulation of inositol-1,4,5-trisphosphate receptor activity
GO:0045429  positive regulation of nitric oxide biosynthetic process
GO:0045944  positive regulation of transcription from RNA polymerase II promoter
GO:0030814  regulation of cAMP metabolic process
GO:0042127  regulation of cell proliferation
GO:0051209  release of sequestered calcium ion into cytosol
GO:0021510  spinal cord development

Cellular Component

GO:0045180  basal cortex
GO:0009925  basal plasma membrane
GO:0005911  cell-cell junction
GO:0005929  cilium
GO:0005737  cytoplasm
GO:0005783  endoplasmic reticulum
GO:0005789  endoplasmic reticulum membrane
GO:0031941  filamentous actin
GO:0071458  integral to cytosolic side of endoplasmic reticulum membrane
GO:0005887  integral to plasma membrane
GO:0030027  lamellipodium
GO:0005932  microtubule basal body
GO:0031512  motile primary cilium
GO:0031513  nonmotile primary cilium
GO:0005886  plasma membrane
GO:0002133  polycystin complex

Molecular Function

GO:0042805  actinin binding
GO:0051117  ATPase binding
GO:0005509  calcium ion binding
GO:0048763  calcium-induced calcium release activity
GO:0008092  cytoskeletal protein binding
GO:0043398  HLH domain binding
GO:0042802  identical protein binding
GO:0005267  potassium channel activity
GO:0005515  protein binding
GO:0042803  protein homodimerization activity
GO:0005102  receptor binding
GO:0005245  voltage-gated calcium channel activity
GO:0022843  voltage-gated cation channel activity
GO:0005244  voltage-gated ion channel activity
GO:0005248  voltage-gated sodium channel activity