phospholipase A2, group IVA (cytosolic, calcium-dependent)

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Synonym

PLA2G4A, PLA2G4, cPLA2-alpha, Cytosolic phospholipase A2, Phospholipase A2 group IVA, CPLA2, MGC126350, cPLA2

normal 40 tissues
cell lines, primary cells, adult tissues and fetal tissues (FANTOM5 CAGE)

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain

blood

connective

EST

cerebrum:8.30

cerebellum:12.60

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:30.70

spine:-

retina:-

eye:11.80

artery/aorta:-

vein:66.60

lymphnode:-

peripheral blood:-

spleen:-

thymus:-

bone marrow:39.40

adipose:-

bone:12.80

skin:28.80

GeneChip

cerebrum:2.97

cerebellum:2.69

brain stem:3.01

corpus callosum/glia:3.31

pineal gland:-

peripheral nerve:3.12

spine:3.60

retina:-

eye:-

artery/aorta:3.81

vein:4.74

lymphnode:4.30

peripheral blood:-

spleen:3.47

thymus:2.65

bone marrow:3.73

adipose:4.73

bone:-

skin:4.25

CAGE

cerebrum:1.73

cerebellum:-

brain stem:2.36

corpus callosum/glia:2.00

pineal gland:2.15

peripheral nerve:-

spine:2.68

retina:-

eye:-

artery/aorta:2.15

vein:2.11

lymphnode:2.12

peripheral blood:-

spleen:2.29

thymus:0.74

bone marrow:-

adipose:2.37

bone:-

skin:-

RNA-seq

cerebrum:0.88

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:2.85

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:1.72

bone:-

skin:-

reproductive

muscular

alimentary

liver

lung

urinary

endo/exo-crine

EST

uterus:9.10

placenta:18.20

prostate:22.50

ovary:37.30

testis:13

heart:12.80

muscle:-

esophagus:-

stomach:-

intestine:-

colon:42.40

liver/hepato:-

lung:-

bladder:-

kidney:20.80

pituitary:-

thyroid/parathyroid:-

adrenal gland:-

pancreas:-

breast:-

salivary:-

GeneChip

uterus:5.11

placenta:2.99

prostate:4.85

ovary:5.07

testis:3.06

heart:3.99

muscle:2.67

esophagus:4.71

stomach:4.21

intestine:3.87

colon:3.44

liver/hepato:2.72

lung:3.55

bladder:-

kidney:3.70

pituitary:2.81

thyroid/parathyroid:3.25

adrenal gland:5.92

pancreas:3.29

breast:4.06

salivary:3.48

CAGE

uterus:2.87

placenta:1.77

prostate:3.21

ovary:2.43

testis:1.82

heart:2.24

muscle:0.90

esophagus:2.48

stomach:-

intestine:3.07

colon:2.04

liver/hepato:1.12

lung:2.29

bladder:3.70

kidney:2.42

pituitary:1.50

thyroid/parathyroid:1.66

adrenal gland:-

pancreas:0.94

breast:2.19

salivary:1.75

RNA-seq

uterus:-

placenta:-

prostate:4.10

ovary:2.20

testis:3.08

heart:0.91

muscle:0.71

esophagus:-

stomach:-

intestine:-

colon:3.22

liver/hepato:0.64

lung:3.14

bladder:-

kidney:2.96

pituitary:-

thyroid/parathyroid:1.80

adrenal gland:2.77

pancreas:-

breast:4.14

salivary:-

IDs

Refseq ID	NM_024420
Gene ID	5321
Unigene ID	Hs.497200
Probe set ID	210145_at [HG-U133_Plus_2]
Ensembl ID	ENSG00000116711
GTEx ID	ENSG00000116711

Orthologous Gene

Mouse[1]	NM_008869
Rat [0]

Chromosomal Region

1q31.1 [186,798,085 - 186,958,113]

Search genes near this gene
- Between -5kb and +5kb
- Between -10kb and +10kb

Gene Family (Interpro ID)

IPR016035	Acyl transferase/acyl hydrolase/lysophospholipase
IPR000008	C2 calcium-dependent membrane targeting
IPR008973	C2 calcium/lipid-binding domain, CaLB
IPR018029	C2 membrane targeting protein
IPR002642	Lysophospholipase, catalytic domain

Gene Ontology (GO ID)

Biological Process

GO:0019369	arachidonic acid metabolic process
GO:0050482	arachidonic acid secretion
GO:0007596	blood coagulation
GO:0071236	cellular response to antibiotic
GO:0046474	glycerophospholipid biosynthetic process
GO:0046456	icosanoid biosynthetic process
GO:0006690	icosanoid metabolic process
GO:0006654	phosphatidic acid biosynthetic process
GO:0009395	phospholipid catabolic process
GO:0006644	phospholipid metabolic process
GO:0006663	platelet activating factor biosynthetic process
GO:0030168	platelet activation
GO:0042127	regulation of cell proliferation

Cellular Component

GO:0016023	cytoplasmic membrane-bounded vesicle
GO:0005829	cytosol
GO:0005789	endoplasmic reticulum membrane
GO:0005794	Golgi apparatus
GO:0005743	mitochondrial inner membrane

Molecular Function

GO:0005509	calcium ion binding
GO:0047498	calcium-dependent phospholipase A2 activity
GO:0005544	calcium-dependent phospholipid binding
GO:0004622	lysophospholipase activity
GO:0004623	phospholipase A2 activity

phospholipase A2, group IVA (cytosolic, calcium-dependent)

Synonym

Expression Pattern

Choropleth map on BodyParts3D

Classification in 40 Organs

Gene Information

IDs

Orthologous Gene

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

Cellular Component

Molecular Function