phospholipase C, gamma 1

Synonym

phospholipase Cgamma1, PLCG1, PLC148, Phospholipase C-gamma-1, PLC-gamma-1, PLC-II, PLC-148, phospholipase C, gamma 1, PLC1, PLCgamma1

normal 40 tissues
cell lines, primary cells, adult tissues and fetal tissues (FANTOM5 CAGE)

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain

blood

connective

EST

cerebrum:45

cerebellum:75.60

brain stem:-

corpus callosum/glia:29.20

pineal gland:-

peripheral nerve:61.30

spine:112.30

retina:-

eye:88.20

artery/aorta:-

vein:-

lymphnode:91

peripheral blood:18.20

spleen:-

thymus:193.30

bone marrow:59

adipose:40.30

bone:38.40

skin:62.40

GeneChip

cerebrum:7.09

cerebellum:7.45

brain stem:6.97

corpus callosum/glia:7.32

pineal gland:-

peripheral nerve:6.97

spine:7.02

retina:-

eye:-

artery/aorta:7.45

vein:7.19

lymphnode:7.73

peripheral blood:-

spleen:7.33

thymus:8.10

bone marrow:6.52

adipose:7.25

bone:-

skin:7.08

CAGE

cerebrum:3.92

cerebellum:-

brain stem:3.76

corpus callosum/glia:4.01

pineal gland:3.18

peripheral nerve:-

spine:3.82

retina:-

eye:-

artery/aorta:3.87

vein:4.35

lymphnode:3.77

peripheral blood:-

spleen:3.27

thymus:4.56

bone marrow:-

adipose:3.78

bone:-

skin:-

RNA-seq

cerebrum:0.78

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:3.72

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:2.84

bone:-

skin:-

reproductive

muscular

alimentary

liver

lung

urinary

endo/exo-crine

EST

uterus:36.50

placenta:40.10

prostate:11.30

ovary:186.30

testis:47.60

heart:25.50

muscle:40.20

esophagus:-

stomach:63.70

intestine:32.40

colon:195

liver/hepato:-

lung:63.50

bladder:-

kidney:20.80

pituitary:-

thyroid/parathyroid:163.70

adrenal gland:-

pancreas:-

breast:18.60

salivary:-

GeneChip

uterus:7.29

placenta:6.81

prostate:6.77

ovary:6.94

testis:7.33

heart:7.15

muscle:6.28

esophagus:6.82

stomach:6.93

intestine:6.80

colon:6.97

liver/hepato:6.46

lung:7.47

bladder:-

kidney:6.87

pituitary:6.77

thyroid/parathyroid:7.36

adrenal gland:7.17

pancreas:6.41

breast:7.25

salivary:6.59

CAGE

uterus:3.91

placenta:2.73

prostate:3.55

ovary:3.44

testis:3.48

heart:3.55

muscle:3.06

esophagus:3.31

stomach:-

intestine:3.30

colon:3.56

liver/hepato:2.33

lung:3.61

bladder:3.42

kidney:2.90

pituitary:3.02

thyroid/parathyroid:3.53

adrenal gland:-

pancreas:2.08

breast:4.39

salivary:3.03

RNA-seq

uterus:-

placenta:-

prostate:2.42

ovary:1.21

testis:2.59

heart:0.34

muscle:0.77

esophagus:-

stomach:-

intestine:-

colon:2.18

liver/hepato:0.00

lung:2.38

bladder:-

kidney:1.75

pituitary:-

thyroid/parathyroid:2.02

adrenal gland:2.27

pancreas:-

breast:1.48

salivary:-

IDs

Refseq ID	NM_182811
Gene ID	5335
Unigene ID	Hs.268177
Probe set ID	202789_at [HG-U133_Plus_2]
Ensembl ID	ENSG00000124181
GTEx ID	ENSG00000124181

Orthologous Gene

Mouse[1]	NM_021280
Rat[1]	NM_013187

Chromosomal Region

20q12 [39,765,600 - 39,804,361]

Search genes near this gene
- Between -5kb and +5kb
- Between -10kb and +10kb

Gene Family (Interpro ID)

IPR000008	C2 calcium-dependent membrane targeting
IPR008973	C2 calcium/lipid-binding domain, CaLB
IPR018029	C2 membrane targeting protein
IPR018249	EF-HAND 2
IPR001849	Pleckstrin homology

Gene Ontology (GO ID)

Biological Process

GO:0000186	activation of MAPKK activity
GO:0007202	activation of phospholipase C activity
GO:0007411	axon guidance
GO:0007596	blood coagulation
GO:0071364	cellular response to epidermal growth factor stimulus
GO:0019221	cytokine-mediated signaling pathway
GO:0007173	epidermal growth factor receptor signaling pathway
GO:0008543	fibroblast growth factor receptor signaling pathway
GO:0001701	in utero embryonic development
GO:0045087	innate immune response
GO:0043647	inositol phosphate metabolic process
GO:0050900	leukocyte migration
GO:0048011	nerve growth factor receptor signaling pathway
GO:0009395	phospholipid catabolic process
GO:0045766	positive regulation of angiogenesis
GO:0043536	positive regulation of blood vessel endothelial cell migration
GO:0010634	positive regulation of epithelial cell migration
GO:0007165	signal transduction
GO:0050852	T cell receptor signaling pathway
GO:0019048	virus-host interaction

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0030027	lamellipodium
GO:0005886	plasma membrane
GO:0001726	ruffle
GO:0008180	signalosome

Molecular Function

GO:0005509	calcium ion binding
GO:0035254	glutamate receptor binding
GO:0005168	neurotrophin TRKA receptor binding
GO:0004435	phosphoinositide phospholipase C activity
GO:0004629	phospholipase C activity
GO:0005543	phospholipid binding
GO:0005515	protein binding
GO:0005057	receptor signaling protein activity
GO:0030971	receptor tyrosine kinase binding

phospholipase C, gamma 1

Synonym

Expression Pattern

Choropleth map on BodyParts3D

Classification in 40 Organs

Gene Information

IDs

Orthologous Gene

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

Cellular Component

Molecular Function