phospholipase C, gamma 2 (phosphatidylinositol-specific)

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Synonym

PLCG2, PLC-gamma2, Phospholipase C-gamma-2, PLC-IV, PLC-gamma-2

normal 40 tissues
cell lines, primary cells, adult tissues and fetal tissues (FANTOM5 CAGE)

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain

blood

connective

EST

cerebrum:17.80

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:30.70

spine:-

retina:-

eye:5.90

artery/aorta:-

vein:199.90

lymphnode:192.10

peripheral blood:18.20

spleen:37.80

thymus:12.90

bone marrow:236.20

adipose:40.30

bone:12.80

skin:33.60

GeneChip

cerebrum:5.87

cerebellum:5.51

brain stem:5.84

corpus callosum/glia:6.19

pineal gland:-

peripheral nerve:6.18

spine:6.25

retina:-

eye:-

artery/aorta:6.53

vein:6.45

lymphnode:8.04

peripheral blood:-

spleen:8.11

thymus:6.51

bone marrow:7.77

adipose:6.86

bone:-

skin:6.42

CAGE

cerebrum:1.83

cerebellum:-

brain stem:2.37

corpus callosum/glia:2.56

pineal gland:2.02

peripheral nerve:-

spine:2.82

retina:-

eye:-

artery/aorta:2.99

vein:4.33

lymphnode:4.59

peripheral blood:-

spleen:4.35

thymus:2.69

bone marrow:-

adipose:2.99

bone:-

skin:-

RNA-seq

cerebrum:0.94

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:3.96

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:3.04

bone:-

skin:-

reproductive

muscular

alimentary

liver

lung

urinary

endo/exo-crine

EST

uterus:173.20

placenta:29.10

prostate:11.30

ovary:-

testis:30.30

heart:12.80

muscle:-

esophagus:-

stomach:106.20

intestine:64.80

colon:17

liver/hepato:52.80

lung:24.40

bladder:-

kidney:31.20

pituitary:-

thyroid/parathyroid:-

adrenal gland:-

pancreas:8.90

breast:65.10

salivary:-

GeneChip

uterus:6.45

placenta:6.27

prostate:5.75

ovary:6.02

testis:5.63

heart:6.38

muscle:5.75

esophagus:6.02

stomach:6.79

intestine:6.71

colon:6.70

liver/hepato:7.39

lung:7.13

bladder:-

kidney:7.61

pituitary:5.78

thyroid/parathyroid:6.28

adrenal gland:6.77

pancreas:6.40

breast:6.40

salivary:6.45

CAGE

uterus:3.17

placenta:2.44

prostate:2.61

ovary:1.98

testis:1.95

heart:2.40

muscle:1.83

esophagus:2.78

stomach:-

intestine:3.34

colon:3.58

liver/hepato:2.31

lung:3.35

bladder:2.94

kidney:3.50

pituitary:1.36

thyroid/parathyroid:2.09

adrenal gland:-

pancreas:1.59

breast:3.38

salivary:2.97

RNA-seq

uterus:-

placenta:-

prostate:2.32

ovary:1.48

testis:1.91

heart:0.85

muscle:1.04

esophagus:-

stomach:-

intestine:-

colon:1.87

liver/hepato:1.65

lung:2.39

bladder:-

kidney:3.48

pituitary:-

thyroid/parathyroid:1.77

adrenal gland:4.47

pancreas:-

breast:2.64

salivary:-

IDs

Refseq ID	NM_002661
Gene ID	5336
Unigene ID	Hs.413111
Probe set ID	204613_at [HG-U133_Plus_2]
Ensembl ID	ENSG00000197943
GTEx ID	ENSG00000197943

Orthologous Gene

Mouse[1]	NM_172285
Rat [0]

Chromosomal Region

16q23.3 [81,812,907 - 81,991,898]

Search genes near this gene
- Between -5kb and +5kb
- Between -10kb and +10kb

Gene Family (Interpro ID)

IPR000008	C2 calcium-dependent membrane targeting
IPR008973	C2 calcium/lipid-binding domain, CaLB
IPR018029	C2 membrane targeting protein
IPR001849	Pleckstrin homology

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

GO:0032237	activation of store-operated calcium channel activity
GO:0030183	B cell differentiation
GO:0050853	B cell receptor signaling pathway
GO:0007596	blood coagulation
GO:0019722	calcium-mediated signaling
GO:0002316	follicular B cell differentiation
GO:0045087	innate immune response
GO:0043647	inositol phosphate metabolic process
GO:0032959	inositol trisphosphate biosynthetic process
GO:0043069	negative regulation of programmed cell death
GO:0006661	phosphatidylinositol biosynthetic process
GO:0009395	phospholipid catabolic process
GO:0030168	platelet activation
GO:0010468	regulation of gene expression
GO:0051209	release of sequestered calcium ion into cytosol
GO:0032496	response to lipopolysaccharide
GO:0050852	T cell receptor signaling pathway
GO:0016055	Wnt receptor signaling pathway

Cellular Component

GO:0005829	cytosol
GO:0005886	plasma membrane

Molecular Function

GO:0004435	phosphoinositide phospholipase C activity
GO:0004629	phospholipase C activity
GO:0005543	phospholipid binding
GO:0005515	protein binding
GO:0004871	signal transducer activity

phospholipase C, gamma 2 (phosphatidylinositol-specific)

Synonym

Expression Pattern

Choropleth map on BodyParts3D

Classification in 40 Organs

Gene Information

IDs

Orthologous Gene

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

Cellular Component

Molecular Function