serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2

Synonym

Alpha-2-plasmin inhibitor, Alpha-2-antiplasmin precursor, Alpha-2-AP, API, PLI, ALPHA-2-PI, alpha-2-plasmin inhibitor, A2AP, AAP, SERPINF2, Alpha-2-PI

normal 40 tissues
cell lines, primary cells, adult tissues and fetal tissues (FANTOM5 CAGE)

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain

blood

connective

EST

cerebrum:5.90

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:118.60

eye:11.80

artery/aorta:-

vein:-

lymphnode:-

peripheral blood:-

spleen:37.80

thymus:-

bone marrow:19.70

adipose:-

bone:-

skin:-

GeneChip

cerebrum:5.27

cerebellum:5.64

brain stem:5.20

corpus callosum/glia:5.30

pineal gland:-

peripheral nerve:5.06

spine:5.09

retina:-

eye:-

artery/aorta:5.33

vein:5.48

lymphnode:5.48

peripheral blood:-

spleen:5.08

thymus:5.10

bone marrow:5.41

adipose:5.30

bone:-

skin:5.30

CAGE

cerebrum:0.36

cerebellum:-

brain stem:0.10

corpus callosum/glia:0.39

pineal gland:0.48

peripheral nerve:-

spine:0

retina:-

eye:-

artery/aorta:1.43

vein:0.96

lymphnode:2.55

peripheral blood:-

spleen:1.29

thymus:0.06

bone marrow:-

adipose:1.37

bone:-

skin:-

RNA-seq

cerebrum:0.13

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:1.66

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:1.52

bone:-

skin:-

reproductive

muscular

alimentary

liver

lung

urinary

endo/exo-crine

EST

uterus:-

placenta:-

prostate:33.80

ovary:-

testis:-

heart:-

muscle:20.10

esophagus:-

stomach:-

intestine:-

colon:8.50

liver/hepato:253.30

lung:-

bladder:-

kidney:166.40

pituitary:-

thyroid/parathyroid:-

adrenal gland:-

pancreas:-

breast:18.60

salivary:-

GeneChip

uterus:5.14

placenta:5.02

prostate:5.30

ovary:5.34

testis:5.29

heart:5.79

muscle:5.40

esophagus:5.35

stomach:5.30

intestine:5.38

colon:5.47

liver/hepato:10.25

lung:5.29

bladder:-

kidney:7.27

pituitary:5.32

thyroid/parathyroid:5.23

adrenal gland:5.44

pancreas:5.96

breast:5.24

salivary:5.33

CAGE

uterus:0.59

placenta:0.30

prostate:2.80

ovary:2.18

testis:3.39

heart:1.24

muscle:1.27

esophagus:0.90

stomach:-

intestine:0.53

colon:0.76

liver/hepato:7.84

lung:1.32

bladder:1.95

kidney:4.26

pituitary:0.71

thyroid/parathyroid:1.88

adrenal gland:-

pancreas:0.94

breast:2.27

salivary:0

RNA-seq

uterus:-

placenta:-

prostate:0.30

ovary:0.87

testis:2.81

heart:0.00

muscle:0.62

esophagus:-

stomach:-

intestine:-

colon:1.14

liver/hepato:6.29

lung:1.25

bladder:-

kidney:3.50

pituitary:-

thyroid/parathyroid:1.33

adrenal gland:2.58

pancreas:-

breast:0.69

salivary:-

IDs

Refseq ID	NM_001165921
Gene ID	5345
Unigene ID	Hs.159509
Probe set ID	205075_at [HG-U133_Plus_2]
Ensembl ID	ENSG00000167711
GTEx ID	ENSG00000167711

Orthologous Gene

Mouse[1]	NM_008878
Rat[1]	NM_001011892

Chromosomal Region

17p13.3 [1,646,130 - 1,658,560]

Search genes near this gene
- Between -5kb and +5kb
- Between -10kb and +10kb

Gene Family (Interpro ID)

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

GO:0006953	acute-phase response
GO:0007596	blood coagulation
GO:0048514	blood vessel morphogenesis
GO:0030199	collagen fibril organization
GO:0042730	fibrinolysis
GO:0010951	negative regulation of endopeptidase activity
GO:0051918	negative regulation of fibrinolysis
GO:0010757	negative regulation of plasminogen activation
GO:0030168	platelet activation
GO:0002576	platelet degranulation
GO:0045597	positive regulation of cell differentiation
GO:0032967	positive regulation of collagen biosynthetic process
GO:0070374	positive regulation of ERK1 and ERK2 cascade
GO:0046330	positive regulation of JNK cascade
GO:0048661	positive regulation of smooth muscle cell proliferation
GO:0051496	positive regulation of stress fiber formation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0002034	regulation of blood vessel size by renin-angiotensin
GO:0030162	regulation of proteolysis
GO:0010033	response to organic substance

Cellular Component

GO:0009986	cell surface
GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005577	fibrinogen complex
GO:0031093	platelet alpha granule lumen

Molecular Function

GO:0004866	endopeptidase inhibitor activity
GO:0002020	protease binding
GO:0005515	protein binding
GO:0042803	protein homodimerization activity
GO:0004867	serine-type endopeptidase inhibitor activity

serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2

Synonym

Expression Pattern

Choropleth map on BodyParts3D

Classification in 40 Organs

Gene Information

IDs

Orthologous Gene

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

Cellular Component

Molecular Function