ADAM metallopeptidase domain 22

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Synonym

a disintegrin and metalloproteinase domain 22, MDC2, ADAM 22 precursor, Metalloproteinase-disintegrin ADAM22-3, ADAM22, ADAM metallopeptidase domain 22, A disintegrin and metalloproteinase domain 22

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:28.40 cerebellum:12.60 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:224.60 retina:- eye:11.80 artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
GeneChip cerebrum:7.94 cerebellum:9.77 brain stem:7.88 corpus callosum/glia:6.64 pineal gland:- peripheral nerve:7.81 spine:7.45 retina:- eye:- artery/aorta:4.47 vein:5.18 lymphnode:4.87 peripheral blood:- spleen:4.34 thymus:5 bone marrow:4.36 adipose:4.74 bone:- skin:4.52
CAGE cerebrum:4.42 cerebellum:- brain stem:3.84 corpus callosum/glia:3.56 pineal gland:2.85 peripheral nerve:- spine:3.87 retina:- eye:- artery/aorta:2.30 vein:2.27 lymphnode:1.53 peripheral blood:- spleen:1.74 thymus:2.71 bone marrow:- adipose:1.88 bone:- skin:-
RNA-seq cerebrum:2.08 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:1.05 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0.33 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:- prostate:11.30 ovary:- testis:- heart:- muscle:- esophagus:- stomach:- intestine:- colon:8.50     liver/hepato:10.60        lung:-    bladder:- kidney:10.40 pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-
GeneChip uterus:5.59 placenta:3.96 prostate:6.07 ovary:4.80 testis:4.27 heart:4.21 muscle:4.60 esophagus:4.04 stomach:4.26 intestine:4.22 colon:4.33 liver/hepato:4.19 lung:4.32 bladder:- kidney:5.07 pituitary:5.83 thyroid/parathyroid:5.35 adrenal gland:6.19 pancreas:4.03 breast:4.50 salivary:4.15
CAGE uterus:3.29 placenta:0.30 prostate:3.05 ovary:2.48 testis:1.76 heart:1.36 muscle:0.97 esophagus:1.29 stomach:- intestine:1.13 colon:1.35     liver/hepato:0.55    lung:1.59 bladder:1.88 kidney:2.34 pituitary:3.13 thyroid/parathyroid:2.39 adrenal gland:- pancreas:1.21 breast:1.68 salivary:0.62
RNA-seq uterus:- placenta:- prostate:0.97 ovary:1.39 testis:1.07 heart:0.11 muscle:0.13 esophagus:- stomach:- intestine:- colon:0.54     liver/hepato:0.02        lung:0.90    bladder:- kidney:1.33 pituitary:- thyroid/parathyroid:0.32 adrenal gland:1.87 pancreas:- breast:1.47 salivary:-

Gene Information

IDs

Refseq ID NM_016351
Gene ID 53616
Unigene ID Hs.592282
Probe set ID 213411_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000008277
GTEx ID ENSG00000008277

Orthologous Gene

Mouse[3]  NM_001007220, NM_001007221, NM_001098225
Rat[3]  NM_001007220, NM_001007221, NM_001098225

Chromosomal Region

7q21.12  [87,563,458  -  87,832,204]

Gene Family (Interpro ID)

-

Link to Pubmed  (Pubmed ID)

9693107
10524237
11050470
12477932
12589811
12853948
14759258
15876356
15882968
16385342
16868027
16990550
17681454
17884303
18440780
18593599
18762889
19054571
20156119
20220021
20379614
21988832
22072566
23455922
23503679
23810013
24227725

Gene Ontology  (GO ID)

Biological Process

GO:0008344  adult locomotory behavior
GO:0007155  cell adhesion
GO:0007417  central nervous system development
GO:0022011  myelination in the peripheral nervous system
GO:0007162  negative regulation of cell adhesion
GO:0006508  proteolysis

Cellular Component

GO:0016021  integral to membrane

Molecular Function

GO:0005178  integrin binding
GO:0004222  metalloendopeptidase activity
GO:0005515  protein binding
GO:0008270  zinc ion binding