polymerase (DNA directed), alpha 1, catalytic subunit

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Synonym

POLA1, DNA polymerase alpha catalytic subunit, polymerase (DNA directed), alpha 1, POLA

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:11.90 cerebellum:25.20 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:61.30 spine:- retina:118.60 eye:23.50 artery/aorta:- vein:- lymphnode:30.30 peripheral blood:18.20 spleen:- thymus:25.80 bone marrow:39.40 adipose:- bone:25.60 skin:24
GeneChip cerebrum:5.63 cerebellum:5.69 brain stem:5.68 corpus callosum/glia:6.21 pineal gland:- peripheral nerve:6.45 spine:5.89 retina:- eye:- artery/aorta:6.05 vein:5.80 lymphnode:6.07 peripheral blood:- spleen:5.85 thymus:7.02 bone marrow:6.43 adipose:5.91 bone:- skin:5.84
CAGE cerebrum:2.10 cerebellum:- brain stem:2.46 corpus callosum/glia:2.65 pineal gland:2.40 peripheral nerve:- spine:2.81 retina:- eye:- artery/aorta:2.17 vein:2.40 lymphnode:2.27 peripheral blood:- spleen:2.36 thymus:3.31 bone marrow:- adipose:2.52 bone:- skin:-
RNA-seq cerebrum:1.41 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:1.79 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:1.76 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:36.50 placenta:18.20 prostate:56.30 ovary:- testis:26 heart:12.80 muscle:- esophagus:- stomach:- intestine:64.80 colon:59.40     liver/hepato:84.40        lung:19.60    bladder:- kidney:20.80 pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:55.80 salivary:-
GeneChip uterus:6.09 placenta:5.60 prostate:6 ovary:5.88 testis:5.64 heart:5.89 muscle:5.99 esophagus:5.92 stomach:5.92 intestine:5.73 colon:5.94 liver/hepato:5.50 lung:5.84 bladder:- kidney:5.64 pituitary:5.71 thyroid/parathyroid:5.81 adrenal gland:5.59 pancreas:5.55 breast:5.93 salivary:5.78
CAGE uterus:2.58 placenta:2.11 prostate:2.27 ovary:2.50 testis:2.06 heart:2.08 muscle:2.66 esophagus:2.18 stomach:- intestine:2.05 colon:2.42     liver/hepato:1.37    lung:2.10 bladder:2.45 kidney:1.87 pituitary:2.18 thyroid/parathyroid:2.10 adrenal gland:- pancreas:1.74 breast:2.11 salivary:2.17
RNA-seq uterus:- placenta:- prostate:2.45 ovary:3.00 testis:2.45 heart:1.42 muscle:1.43 esophagus:- stomach:- intestine:- colon:2.21     liver/hepato:0.73        lung:1.31    bladder:- kidney:1.62 pituitary:- thyroid/parathyroid:2.14 adrenal gland:2.10 pancreas:- breast:1.70 salivary:-

Gene Information

IDs

Refseq ID NM_016937
Gene ID 5422
Unigene ID Hs.567319
Probe set ID 204835_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000101868
GTEx ID ENSG00000101868

Orthologous Gene

Mouse[1]  NM_008892
Rat [0]  

Chromosomal Region

Xp22.11  [24,712,036  -  25,015,103]

Gene Family (Interpro ID)

IPR006172  DNA-directed DNA polymerase, family B
IPR004578  DNA-directed DNA polymerase, family B, pol2

Link to Pubmed  (Pubmed ID)

893425
1311258
1508673
1689958
1730053
1848671
1903085
2005899
2175912
2243771
2410918
3139084
3335506
3359994
3490907
3820307
3917431
4084590
6693436
7045121
7085672
7504813
7910375
8223465
8226963
8760400
8889548
9039979
9395244
9518481
9563011
9815285
9822671
10518787
10869558
10877824
11259605
11470886
11473323
11917009
11968016
12181327
12220650
12393188
12546699
12665598
12950174
14499601
15146197
15615704
16438930
16762037
16935576
17209555
17699597
17761813
18029348
19177015
19471022
19608746
19615732
21139048
21705323
21890473
21963094
22053931
22505724
22586326
22593576
22623531
22678362
22679391
22863883
22887995
22918585
22939629
23390603
24250222
24332808
24816145

Gene Ontology  (GO ID)

Biological Process

GO:0008283  cell proliferation
GO:0006281  DNA repair
GO:0006260  DNA replication
GO:0006270  DNA replication initiation
GO:0006269  DNA replication, synthesis of RNA primer
GO:0006271  DNA strand elongation during DNA replication
GO:0000731  DNA synthesis during DNA repair
GO:0006303  double-strand break repair via nonhomologous end joining
GO:0000082  G1/S transition of mitotic cell cycle
GO:0006273  lagging strand elongation
GO:0006272  leading strand elongation
GO:0000278  mitotic cell cycle
GO:0006297  nucleotide-excision repair, DNA gap filling
GO:0000083  regulation of transcription involved in G1/S-phase of mitotic cell cycle
GO:0000084  S phase of mitotic cell cycle
GO:0000723  telomere maintenance
GO:0000722  telomere maintenance via recombination
GO:0032201  telomere maintenance via semi-conservative replication
GO:0019985  translesion synthesis
GO:0019048  virus-host interaction

Cellular Component

GO:0005658  alpha DNA polymerase:primase complex
GO:0000785  chromatin
GO:0005737  cytoplasm
GO:0043231  intracellular membrane-bounded organelle
GO:0005635  nuclear envelope
GO:0016363  nuclear matrix
GO:0005730  nucleolus
GO:0005654  nucleoplasm
GO:0005634  nucleus

Molecular Function

GO:0008408  3'-5' exonuclease activity
GO:0051539  4 iron, 4 sulfur cluster binding
GO:0003682  chromatin binding
GO:0003677  DNA binding
GO:0003896  DNA primase activity
GO:0003887  DNA-directed DNA polymerase activity
GO:0046872  metal ion binding
GO:0001882  nucleoside binding
GO:0000166  nucleotide binding
GO:0005515  protein binding
GO:0046982  protein heterodimerization activity