wingless-type MMTV integration site family, member 4

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Synonym

WNT4, WNT-4, UNQ426/PRO864, Protein Wnt-4 precursor

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:56.90 cerebellum:25.20 brain stem:- corpus callosum/glia:145.80 pineal gland:- peripheral nerve:61.30 spine:112.30 retina:- eye:23.50 artery/aorta:929.20 vein:133.30 lymphnode:80.90 peripheral blood:18.20 spleen:18.90 thymus:141.70 bone marrow:39.40 adipose:40.30 bone:166.30 skin:67.20
GeneChip cerebrum:3.68 cerebellum:3.55 brain stem:3.82 corpus callosum/glia:3.53 pineal gland:- peripheral nerve:3.47 spine:3.90 retina:- eye:- artery/aorta:3.82 vein:3.89 lymphnode:3.88 peripheral blood:- spleen:3.30 thymus:3.42 bone marrow:3.74 adipose:3.96 bone:- skin:5.45
CAGE cerebrum:0.28 cerebellum:- brain stem:0.35 corpus callosum/glia:0.34 pineal gland:1.21 peripheral nerve:- spine:0.41 retina:- eye:- artery/aorta:0.59 vein:0.47 lymphnode:0.51 peripheral blood:- spleen:0 thymus:0.54 bone marrow:- adipose:0 bone:- skin:-
RNA-seq cerebrum:0.43 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:0.06 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0.08 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:109.40 placenta:116.60 prostate:33.80 ovary:- testis:99.50 heart:76.60 muscle:40.20 esophagus:- stomach:21.20 intestine:64.80 colon:17     liver/hepato:42.20        lung:122.20    bladder:125.60 kidney:176.80 pituitary:- thyroid/parathyroid:- adrenal gland:152.40 pancreas:71.10 breast:55.80 salivary:-
GeneChip uterus:4.54 placenta:3.87 prostate:4.29 ovary:4.72 testis:3.63 heart:3.61 muscle:4.08 esophagus:5.21 stomach:4.01 intestine:4.29 colon:4.06 liver/hepato:3.59 lung:3.65 bladder:- kidney:3.71 pituitary:4.48 thyroid/parathyroid:3.62 adrenal gland:5.94 pancreas:5.14 breast:4.86 salivary:4.02
CAGE uterus:1.22 placenta:2.08 prostate:1.85 ovary:3.15 testis:0.40 heart:0.18 muscle:0.47 esophagus:1.36 stomach:- intestine:1.24 colon:0.71     liver/hepato:0.55    lung:0.34 bladder:0.58 kidney:0.15 pituitary:0.96 thyroid/parathyroid:0.32 adrenal gland:- pancreas:0.58 breast:0 salivary:0.83
RNA-seq uterus:- placenta:- prostate:0.63 ovary:4.54 testis:0.74 heart:0.03 muscle:0.72 esophagus:- stomach:- intestine:- colon:0.40     liver/hepato:0.02        lung:0.37    bladder:- kidney:0.45 pituitary:- thyroid/parathyroid:0.24 adrenal gland:0.11 pancreas:- breast:0.55 salivary:-

Gene Information

IDs

Refseq ID NM_030761
Gene ID 54361
Unigene ID Hs.257664
Probe set ID 208606_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000162552
GTEx ID ENSG00000162552

Orthologous Gene

Mouse[1]  NM_009523
Rat[1]  NM_053402

Chromosomal Region

1p36.12  [22,446,461  -  22,470,462]

Gene Family (Interpro ID)

IPR005816  Secreted growth factor Wnt protein
IPR005817  Wnt superfamily
IPR009142  Wnt-4 protein

Link to Pubmed  (Pubmed ID)

2279700
8167409
8168088
9853965
9989404
10654605
10866835
11283799
11287180
12142017
12477932
12768078
12841867
12844346
12949260
12975309
15040835
15149334
15265686
15312687
15317892
15389636
15489334
15589122
15717329
16343436
16368682
16442268
16710414
16959810
16981135
17720811
17848411
17976063
18001722
18179883
18182450
18281035
18553255
19034702
19171330
19421142
19453261
19849868
19863181
19962424
20060343
20161747
20301714
20502698
20601957
20634891
20709709
21280163
21377155
21624127
21732829
21832049
21988832
22041457
22503279
22504420
22951804
23044875
23104006
23142796
23142810
23251661
23463699
23472165
23520208
24130753
24274766

Gene Ontology  (GO ID)

Biological Process

GO:0030325  adrenal gland development
GO:0006702  androgen biosynthetic process
GO:0001658  branching involved in ureteric bud morphogenesis
GO:0045165  cell fate commitment
GO:0007267  cell-cell signaling
GO:0001838  embryonic epithelial tube formation
GO:0001837  epithelial to mesenchymal transition
GO:0090002  establishment of protein localization in plasma membrane
GO:0008585  female gonad development
GO:0030237  female sex determination
GO:0033080  immature T cell proliferation in the thymus
GO:0001822  kidney development
GO:0001889  liver development
GO:0008584  male gonad development
GO:0060231  mesenchymal to epithelial transition
GO:0043066  negative regulation of apoptosis
GO:0045596  negative regulation of cell differentiation
GO:0030336  negative regulation of cell migration
GO:0040037  negative regulation of fibroblast growth factor receptor signaling pathway
GO:0010629  negative regulation of gene expression
GO:0010894  negative regulation of steroid biosynthetic process
GO:0045892  negative regulation of transcription, DNA-dependent
GO:0090090  negative regulation of Wnt receptor signaling pathway through beta-catenin
GO:0030182  neuron differentiation
GO:0048599  oocyte development
GO:0032349  positive regulation of aldosterone biosynthetic process
GO:0030501  positive regulation of bone mineralization
GO:0032967  positive regulation of collagen biosynthetic process
GO:0051894  positive regulation of focal adhesion formation
GO:0045836  positive regulation of meiosis
GO:0045669  positive regulation of osteoblast differentiation
GO:0032321  positive regulation of Rho GTPase activity
GO:0051496  positive regulation of stress fiber formation
GO:0045893  positive regulation of transcription, DNA-dependent
GO:0018345  protein palmitoylation
GO:0022407  regulation of cell-cell adhesion
GO:0051145  smooth muscle cell differentiation
GO:0060126  somatotropin secreting cell differentiation
GO:0060748  tertiary branching involved in mammary gland duct morphogenesis
GO:0060129  thyroid stimulating hormone secreting cell differentiation
GO:0060070  Wnt receptor signaling pathway through beta-catenin

Cellular Component

GO:0009986  cell surface
GO:0005737  cytoplasm
GO:0005788  endoplasmic reticulum lumen
GO:0005576  extracellular region
GO:0005615  extracellular space
GO:0005796  Golgi lumen
GO:0005886  plasma membrane
GO:0005578  proteinaceous extracellular matrix

Molecular Function

GO:0005201  extracellular matrix structural constituent
GO:0005109  frizzled binding
GO:0048018  receptor agonist activity
GO:0003714  transcription corepressor activity