mediator complex subunit 1

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Synonym

TRIP-2, Trap220, TRIP2, PPARGBP, PPAR-binding protein, RB18A, p53 regulatory protein RB18A, ARC205, MED1, MGC71488, PPARBP, CRSP200, TRAP220, CRSP1, DRIP205, Activator-recruited cofactor 205 kDa component, DRIP230, Thyroid receptor-interacting protein 2, PPAR binding protein

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:1.20 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:11.80 artery/aorta:- vein:- lymphnode:10.10 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:9.60
GeneChip cerebrum:5.87 cerebellum:5.94 brain stem:5.81 corpus callosum/glia:6.08 pineal gland:- peripheral nerve:6.36 spine:5.94 retina:- eye:- artery/aorta:6.17 vein:6.11 lymphnode:6.97 peripheral blood:- spleen:7.40 thymus:7.42 bone marrow:6.36 adipose:6.67 bone:- skin:6.62
CAGE cerebrum:2.30 cerebellum:- brain stem:2.48 corpus callosum/glia:2.82 pineal gland:1.90 peripheral nerve:- spine:2.28 retina:- eye:- artery/aorta:2.48 vein:2.49 lymphnode:2.75 peripheral blood:- spleen:2.82 thymus:3.21 bone marrow:- adipose:2.70 bone:- skin:-
RNA-seq cerebrum:2.24 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:2.86 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:2.91 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:9.10 placenta:- prostate:- ovary:- testis:- heart:- muscle:- esophagus:- stomach:- intestine:- colon:-     liver/hepato:-        lung:9.80    bladder:- kidney:10.40 pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-
GeneChip uterus:7.15 placenta:6.33 prostate:7.12 ovary:7.09 testis:6.67 heart:6.30 muscle:6.35 esophagus:6.40 stomach:6.62 intestine:6 colon:6.06 liver/hepato:6.26 lung:6.36 bladder:- kidney:6.33 pituitary:5.90 thyroid/parathyroid:6.59 adrenal gland:6.43 pancreas:5.57 breast:7.03 salivary:6.24
CAGE uterus:2.52 placenta:2.61 prostate:2.47 ovary:2.95 testis:2.74 heart:2.35 muscle:1.99 esophagus:2.34 stomach:- intestine:2.45 colon:2.56     liver/hepato:2.31    lung:2.41 bladder:2.49 kidney:2.41 pituitary:2.60 thyroid/parathyroid:2.33 adrenal gland:- pancreas:2.71 breast:2.47 salivary:2.01
RNA-seq uterus:- placenta:- prostate:2.99 ovary:3.49 testis:2.81 heart:2.46 muscle:2.37 esophagus:- stomach:- intestine:- colon:2.64     liver/hepato:1.79        lung:2.18    bladder:- kidney:2.39 pituitary:- thyroid/parathyroid:2.87 adrenal gland:3.03 pancreas:- breast:2.56 salivary:-

Gene Information

IDs

Refseq ID NM_004774
Gene ID 5469
Unigene ID Hs.643754
Probe set ID 203497_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000125686
GTEx ID ENSG00000125686

Orthologous Gene

Mouse[12]  NM_001080118, NM_013634, NM_134027
Rat[1]  NM_001134361, NM_013634, NM_134027

Chromosomal Region

17q12  [37,560,538  -  37,607,521]

Gene Family (Interpro ID)

-

Link to Pubmed  (Pubmed ID)

7776974
8710870
9325263
9444950
9653119
9989412
10024883
10037764
10198638
10235266
10235267
10478845
10485914
10508170
10733574
10760302
10770935
10882111
10935544
11027271
11117530
11118038
11266503
11438648
11500849
11724781
11840331
11867769
11912212
12037571
12082103
12089346
12101254
12130544
12145330
12189208
12218053
12356758
12477932
12556447
12562779
12584197
12738788
12796488
14636573
14638676
14657022
14983011
15026545
15095040
15175163
15187081
15302935
15342556
15471764
15572376
15604093
15848166
15863722
15886699
15919092
15989967
16055720
16204234
16239144
16239257
16314496
16396960
16434701
16554032
16574658
16723356
16799563
16934225
16964243
17081983
17082781
17117180
17132730
17223341
17254542
17468099
17478428
17502350
17641689
17786964
17827210
17967894
18003614
18339625
18391015
18418385
18660489
18691967
18950845
19127118
19183483
19243021
19255064
19322201
19497978
19521987
19766566
19913121
19946888
20098423
20133760
20160030
20398753
20473893
20508642
20520624
20534441
20628086
21139048
21292004
21326907
21454576
21556051
21729782
21868449
21988832
22102282
22331469
22342682
22343046
22869146
22939629
22964581
23160722
23275444
23322298
23538858
23563140
23602568
23824909
23936234
24245781
24816145

Gene Ontology  (GO ID)

Biological Process

GO:0006702  androgen biosynthetic process
GO:0030521  androgen receptor signaling pathway
GO:0001525  angiogenesis
GO:0007420  brain development
GO:0000902  cell morphogenesis
GO:0044255  cellular lipid metabolic process
GO:0071364  cellular response to epidermal growth factor stimulus
GO:0071383  cellular response to steroid hormone stimulus
GO:0006260  DNA replication
GO:0035050  embryonic heart tube development
GO:0035162  embryonic hemopoiesis
GO:0035116  embryonic hindlimb morphogenesis
GO:0001892  embryonic placenta development
GO:0048822  enucleate erythrocyte development
GO:0060750  epithelial cell proliferation involved in mammary gland duct elongation
GO:0070371  ERK1 and ERK2 cascade
GO:0048821  erythrocyte development
GO:0045444  fat cell differentiation
GO:0010467  gene expression
GO:0030216  keratinocyte differentiation
GO:0007595  lactation
GO:0002088  lens development in camera-type eye
GO:0001889  liver development
GO:0060745  mammary gland branching involved in pregnancy
GO:0060744  mammary gland branching involved in thelarche
GO:0030224  monocyte differentiation
GO:0042789  mRNA transcription from RNA polymerase II promoter
GO:0043066  negative regulation of apoptosis
GO:0010839  negative regulation of keratinocyte proliferation
GO:0045665  negative regulation of neuron differentiation
GO:0000122  negative regulation of transcription from RNA polymerase II promoter
GO:0031100  organ regeneration
GO:0033148  positive regulation of estrogen receptor signaling pathway
GO:0070318  positive regulation of G0 to G1 transition
GO:0010628  positive regulation of gene expression
GO:0060335  positive regulation of interferon-gamma-mediated signaling pathway
GO:0045618  positive regulation of keratinocyte differentiation
GO:0033601  positive regulation of mammary gland epithelial cell proliferation
GO:0033160  positive regulation of protein import into nucleus, translocation
GO:0045944  positive regulation of transcription from RNA polymerase II promoter
GO:0045893  positive regulation of transcription, DNA-dependent
GO:0051726  regulation of cell cycle
GO:0006356  regulation of transcription from RNA polymerase I promoter
GO:0070562  regulation of vitamin D receptor signaling pathway
GO:0003406  retinal pigment epithelium development
GO:0030518  steroid hormone receptor signaling pathway
GO:0006590  thyroid hormone generation
GO:0002154  thyroid hormone mediated signaling pathway
GO:0006367  transcription initiation from RNA polymerase II promoter
GO:0003222  ventricular trabecular myocardium morphogenesis

Cellular Component

GO:0016592  mediator complex
GO:0005730  nucleolus
GO:0005654  nucleoplasm
GO:0005634  nucleus

Molecular Function

GO:0003682  chromatin binding
GO:0030331  estrogen receptor binding
GO:0050693  LBD domain binding
GO:0016922  ligand-dependent nuclear receptor binding
GO:0030374  ligand-dependent nuclear receptor transcription coactivator activity
GO:0042975  peroxisome proliferator activated receptor binding
GO:0005515  protein binding
GO:0004872  receptor activity
GO:0042974  retinoic acid receptor binding
GO:0046966  thyroid hormone receptor binding
GO:0030375  thyroid hormone receptor coactivator activity
GO:0003713  transcription coactivator activity
GO:0003712  transcription cofactor activity
GO:0008134  transcription factor binding
GO:0042809  vitamin D receptor binding