synaptotagmin-like 2

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Synonym

exophilin-4, Synaptotagmin-like protein 2, CHR11SYT, MGC102768, FLJ20163, SGA72M, synaptotagmin-like 2, Exophilin-4, KIAA1597, FLJ21219, SYTL2, SLP2

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:66.40 cerebellum:37.80 brain stem:- corpus callosum/glia:204.10 pineal gland:- peripheral nerve:30.70 spine:- retina:- eye:- artery/aorta:- vein:66.60 lymphnode:60.70 peripheral blood:- spleen:- thymus:25.80 bone marrow:- adipose:80.70 bone:- skin:43.20
GeneChip nodata
CAGE cerebrum:3.19 cerebellum:- brain stem:3.18 corpus callosum/glia:2.96 pineal gland:1.42 peripheral nerve:- spine:3.69 retina:- eye:- artery/aorta:3.04 vein:2.90 lymphnode:2.14 peripheral blood:- spleen:2.40 thymus:2.60 bone marrow:- adipose:2.69 bone:- skin:-
RNA-seq cerebrum:0.61 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:0.03 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0.39 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:173.20 placenta:51 prostate:45.10 ovary:- testis:21.60 heart:38.30 muscle:60.30 esophagus:- stomach:21.20 intestine:32.40 colon:152.60     liver/hepato:10.60        lung:48.90    bladder:125.60 kidney:93.60 pituitary:- thyroid/parathyroid:- adrenal gland:50.80 pancreas:- breast:158 salivary:-
GeneChip nodata
CAGE uterus:2.98 placenta:2.48 prostate:3.29 ovary:2.43 testis:2.14 heart:2.25 muscle:2.13 esophagus:2.25 stomach:- intestine:3.74 colon:3.87     liver/hepato:2.03    lung:3.07 bladder:3.34 kidney:3.29 pituitary:2.50 thyroid/parathyroid:1.28 adrenal gland:- pancreas:0.94 breast:3.22 salivary:2.50
RNA-seq uterus:- placenta:- prostate:1.21 ovary:0.26 testis:2.11 heart:0.55 muscle:0.00 esophagus:- stomach:- intestine:- colon:0.26     liver/hepato:0.03        lung:2.50    bladder:- kidney:0.16 pituitary:- thyroid/parathyroid:0.00 adrenal gland:0.88 pancreas:- breast:0.99 salivary:-

Gene Information

IDs

Refseq ID NM_001162952
Gene ID 54843
Unigene ID Hs.369520
Probe set ID -
Ensembl ID ENSG00000137501
GTEx ID ENSG00000137501

Orthologous Gene

Mouse[5]  NM_001040085, NM_001040086, NM_001040087, NM_001040088, NM_031394
Rat[5]  NM_001040085, NM_001040086, NM_001040087, NM_001040088, NM_031394

Chromosomal Region

11q14.1  [85,405,267  -  85,522,184]

Gene Family (Interpro ID)

IPR000008  C2 calcium-dependent membrane targeting
IPR008973  C2 calcium/lipid-binding domain, CaLB
IPR018029  C2 membrane targeting protein
IPR010911  Rab-binding domain
IPR011011  Zinc finger, FYVE/PHD-type
IPR013083  Zinc finger, RING/FYVE/PHD-type

Link to Pubmed  (Pubmed ID)

8125298
8976547
10737800
10865129
10997877
11243866
11327731
11543631
11773082
11980908
12477932
12590134
14702039
15231748
15489334
16051665
16303743
16344560
17182843
17207965
17643375
17672918
18029348
18266782
18812475
18832576
18940603
19389623
20195357
20654157
20729199
21223688
22724020
22820376
23000965
23940030
24284068

Gene Ontology  (GO ID)

Biological Process

GO:0006887  exocytosis
GO:0006886  intracellular protein transport
GO:0010923  negative regulation of phosphatase activity
GO:0006904  vesicle docking during exocytosis
GO:0016192  vesicle-mediated transport

Cellular Component

GO:0005737  cytoplasm
GO:0070382  exocytic vesicle
GO:0019897  extrinsic to plasma membrane
GO:0005794  Golgi apparatus
GO:0042470  melanosome
GO:0016020  membrane
GO:0005634  nucleus
GO:0005886  plasma membrane

Molecular Function

GO:0042043  neurexin binding
GO:0019902  phosphatase binding
GO:0005546  phosphatidylinositol-4,5-bisphosphate binding
GO:0001786  phosphatidylserine binding
GO:0005515  protein binding
GO:0017137  Rab GTPase binding