protein phosphatase 1A (formerly 2C), magnesium-dependent, alpha isoform

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Synonym

PP2CA, IA, PPM1A, MGC9201, PPPM1A, Protein phosphatase 2C isoform alpha, PP2C-alpha, PP2C-ALPHA, Protein phosphatase 1A

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:34.40 cerebellum:50.40 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:118.60 eye:23.50 artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:51.50 bone marrow:19.70 adipose:80.70 bone:12.80 skin:4.80
GeneChip cerebrum:7.36 cerebellum:7.38 brain stem:7.52 corpus callosum/glia:7.57 pineal gland:- peripheral nerve:7.45 spine:7.41 retina:- eye:- artery/aorta:7.19 vein:7.69 lymphnode:7.44 peripheral blood:- spleen:7.53 thymus:8.01 bone marrow:8.46 adipose:7.64 bone:- skin:7.56
CAGE cerebrum:3.68 cerebellum:- brain stem:3.73 corpus callosum/glia:3.55 pineal gland:3.28 peripheral nerve:- spine:3.20 retina:- eye:- artery/aorta:3.44 vein:3.26 lymphnode:3.08 peripheral blood:- spleen:3.27 thymus:3.85 bone marrow:- adipose:3.66 bone:- skin:-
RNA-seq cerebrum:0.30 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:2.65 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:2.26 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:27.30 placenta:25.50 prostate:45.10 ovary:37.30 testis:8.70 heart:- muscle:40.20 esophagus:- stomach:21.20 intestine:- colon:-     liver/hepato:21.10        lung:24.40    bladder:- kidney:31.20 pituitary:- thyroid/parathyroid:163.70 adrenal gland:50.80 pancreas:8.90 breast:- salivary:-
GeneChip uterus:7.43 placenta:8.10 prostate:8.15 ovary:7.12 testis:8.52 heart:8.11 muscle:8.59 esophagus:7.80 stomach:7.71 intestine:7.97 colon:7.74 liver/hepato:8.15 lung:7.72 bladder:- kidney:8.18 pituitary:7.47 thyroid/parathyroid:7.55 adrenal gland:7.27 pancreas:7.38 breast:7.78 salivary:8.37
CAGE uterus:3.55 placenta:3.56 prostate:3.70 ovary:3.27 testis:4.03 heart:3.88 muscle:4.21 esophagus:3.65 stomach:- intestine:4.06 colon:3.78     liver/hepato:3.77    lung:3.78 bladder:3.66 kidney:3.59 pituitary:3.38 thyroid/parathyroid:3.45 adrenal gland:- pancreas:3.10 breast:3.49 salivary:3.37
RNA-seq uterus:- placenta:- prostate:2.80 ovary:0.10 testis:0.27 heart:3.07 muscle:4.19 esophagus:- stomach:- intestine:- colon:0.83     liver/hepato:2.19        lung:3.38    bladder:- kidney:1.91 pituitary:- thyroid/parathyroid:0.45 adrenal gland:0.00 pancreas:- breast:1.73 salivary:-

Gene Information

IDs

Refseq ID NM_021003
Gene ID 5494
Unigene ID Hs.130036
Probe set ID 203966_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000100614
GTEx ID ENSG00000100614

Orthologous Gene

Mouse[2]  NM_008910
Rat [0]  

Chromosomal Region

14q23.1  [60,712,470  -  60,765,805]

Gene Family (Interpro ID)

IPR001932  Protein phosphatase 2C-related

Link to Pubmed  (Pubmed ID)

1311954
8386634
9003755
9707433
10400656
10480873
10580002
10644691
11479720
11559703
11959144
12477932
12514180
12761501
14663150
14702039
15016818
15489334
15728831
16344560
16541025
16712791
16751101
16931515
17353931
17620599
17729405
18482992
18829461
18930133
19404668
20379614
20970119
21139048
21988832
22036096
22041443
22519956
22588298
22727189
23000965
23184937
23560844
23779087
23906386
24337577
24816145

Gene Ontology  (GO ID)

Biological Process

GO:0007050  cell cycle arrest
GO:0016311  dephosphorylation
GO:0010467  gene expression
GO:0008286  insulin receptor signaling pathway
GO:0006499  N-terminal protein myristoylation
GO:0043124  negative regulation of I-kappaB kinase/NF-kappaB cascade
GO:0042347  negative regulation of NF-kappaB import into nucleus
GO:0010991  negative regulation of SMAD protein complex assembly
GO:0000122  negative regulation of transcription from RNA polymerase II promoter
GO:0030512  negative regulation of transforming growth factor beta receptor signaling pathway
GO:0043123  positive regulation of I-kappaB kinase/NF-kappaB cascade
GO:0045893  positive regulation of transcription, DNA-dependent
GO:0030177  positive regulation of Wnt receptor signaling pathway
GO:0006470  protein amino acid dephosphorylation
GO:0006367  transcription initiation from RNA polymerase II promoter
GO:0006351  transcription, DNA-dependent
GO:0007179  transforming growth factor beta receptor signaling pathway
GO:0016055  Wnt receptor signaling pathway

Cellular Component

GO:0005829  cytosol
GO:0016020  membrane
GO:0043005  neuron projection
GO:0005654  nucleoplasm
GO:0005634  nucleus
GO:0005891  voltage-gated calcium channel complex

Molecular Function

GO:0033192  calmodulin-dependent protein phosphatase activity
GO:0000287  magnesium ion binding
GO:0030145  manganese ion binding
GO:0005515  protein binding
GO:0008022  protein C-terminus binding
GO:0004722  protein serine/threonine phosphatase activity
GO:0070412  R-SMAD binding
GO:0004871  signal transducer activity