protein phosphatase 3 (formerly 2B), catalytic subunit, alpha isoform

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Synonym

PPP3CA, CALN, CALNA, PPP2B, CNA1, CNA, CALNA1

normal 40 tissues
cell lines, primary cells, adult tissues and fetal tissues (FANTOM5 CAGE)

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain

blood

connective

EST

cerebrum:90.10

cerebellum:75.60

brain stem:-

corpus callosum/glia:58.30

pineal gland:741.70

peripheral nerve:368.10

spine:224.60

retina:-

eye:105.80

artery/aorta:149.90

vein:-

lymphnode:70.80

peripheral blood:72.90

spleen:113.40

thymus:51.50

bone marrow:78.70

adipose:-

bone:76.80

skin:134.40

GeneChip

cerebrum:9.48

cerebellum:9.58

brain stem:8.54

corpus callosum/glia:8.30

pineal gland:-

peripheral nerve:8.68

spine:8.54

retina:-

eye:-

artery/aorta:7.70

vein:8.29

lymphnode:8.24

peripheral blood:-

spleen:8.23

thymus:7.63

bone marrow:7.94

adipose:8.23

bone:-

skin:7.92

CAGE

cerebrum:4.75

cerebellum:-

brain stem:3.70

corpus callosum/glia:3.45

pineal gland:3.53

peripheral nerve:-

spine:3.24

retina:-

eye:-

artery/aorta:3.35

vein:3.82

lymphnode:3.57

peripheral blood:-

spleen:3.39

thymus:3.05

bone marrow:-

adipose:4.07

bone:-

skin:-

RNA-seq

cerebrum:6.68

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:0

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:0.00

bone:-

skin:-

reproductive

muscular

alimentary

liver

lung

urinary

endo/exo-crine

EST

uterus:100.20

placenta:43.70

prostate:326.70

ovary:-

testis:34.60

heart:38.30

muscle:80.40

esophagus:-

stomach:42.50

intestine:97.20

colon:67.80

liver/hepato:52.80

lung:92.90

bladder:-

kidney:20.80

pituitary:232

thyroid/parathyroid:-

adrenal gland:101.60

pancreas:8.90

breast:204.40

salivary:-

GeneChip

uterus:7.92

placenta:6.78

prostate:9.73

ovary:8.19

testis:7.15

heart:7.69

muscle:8.46

esophagus:8.04

stomach:8.14

intestine:7.84

colon:7.37

liver/hepato:7.77

lung:8.04

bladder:-

kidney:7.06

pituitary:7.83

thyroid/parathyroid:7.99

adrenal gland:8.41

pancreas:7.70

breast:8.27

salivary:8.13

CAGE

uterus:3.68

placenta:2.94

prostate:4.44

ovary:3.50

testis:3.44

heart:3.30

muscle:3.54

esophagus:3.24

stomach:-

intestine:3.20

colon:3.27

liver/hepato:2.73

lung:3.71

bladder:3.63

kidney:2.76

pituitary:2.92

thyroid/parathyroid:3.05

adrenal gland:-

pancreas:2.66

breast:3.56

salivary:3.71

RNA-seq

uterus:-

placenta:-

prostate:0.00

ovary:0.36

testis:0.19

heart:1.73

muscle:3.81

esophagus:-

stomach:-

intestine:-

colon:0.23

liver/hepato:0.00

lung:0.00

bladder:-

kidney:0.00

pituitary:-

thyroid/parathyroid:1.84

adrenal gland:1.15

pancreas:-

breast:0.13

salivary:-

IDs

Refseq ID	NM_000944
Gene ID	5530
Unigene ID	Hs.435512
Probe set ID	202425_x_at [HG-U133_Plus_2]
Ensembl ID	ENSG00000138814
GTEx ID	ENSG00000138814

Orthologous Gene

Mouse[1]	NM_008913
Rat [0]

Chromosomal Region

4q24 [101,944,566 - 102,269,435]

Search genes near this gene
- Between -5kb and +5kb
- Between -10kb and +10kb

Gene Family (Interpro ID)

IPR004843	Metallophosphoesterase
IPR006186	Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase

Gene Ontology (GO ID)

Biological Process

GO:0033173	calcineurin-NFAT signaling pathway
GO:0006816	calcium ion transport
GO:0071333	cellular response to glucose stimulus
GO:0016311	dephosphorylation
GO:0000082	G1/S transition of mitotic cell cycle
GO:0045087	innate immune response
GO:0046676	negative regulation of insulin secretion
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0006470	protein amino acid dephosphorylation
GO:0006606	protein import into nucleus
GO:0060079	regulation of excitatory postsynaptic membrane potential
GO:0050804	regulation of synaptic transmission
GO:0001975	response to amphetamine
GO:0051592	response to calcium ion
GO:0048741	skeletal muscle fiber development
GO:0042110	T cell activation
GO:0014883	transition between fast and slow fiber

Cellular Component

GO:0005955	calcineurin complex
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0016020	membrane
GO:0005739	mitochondrion
GO:0005730	nucleolus
GO:0005654	nucleoplasm
GO:0005634	nucleus
GO:0030018	Z disc

Molecular Function

GO:0005509	calcium ion binding
GO:0005516	calmodulin binding
GO:0033192	calmodulin-dependent protein phosphatase activity
GO:0008144	drug binding
GO:0019899	enzyme binding
GO:0005515	protein binding
GO:0046983	protein dimerization activity
GO:0046982	protein heterodimerization activity
GO:0004722	protein serine/threonine phosphatase activity

protein phosphatase 3 (formerly 2B), catalytic subunit, alpha isoform

Synonym

Expression Pattern

Choropleth map on BodyParts3D

Classification in 40 Organs

Gene Information

IDs

Orthologous Gene

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

Cellular Component

Molecular Function