protein phosphatase 3 (formerly 2B), catalytic subunit, beta isoform

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Synonym

CALNA2, PPP3CB, CALNB

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:123.30 cerebellum:151.10 brain stem:- corpus callosum/glia:58.30 pineal gland:- peripheral nerve:61.30 spine:112.30 retina:- eye:47 artery/aorta:60 vein:- lymphnode:70.80 peripheral blood:91.10 spleen:37.80 thymus:103.10 bone marrow:19.70 adipose:80.70 bone:89.60 skin:57.60
GeneChip cerebrum:9.40 cerebellum:10.03 brain stem:8.74 corpus callosum/glia:7.57 pineal gland:- peripheral nerve:8.57 spine:8.14 retina:- eye:- artery/aorta:8.65 vein:8.84 lymphnode:8.28 peripheral blood:- spleen:7.99 thymus:8.77 bone marrow:7.96 adipose:8.69 bone:- skin:8.43
CAGE cerebrum:5.26 cerebellum:- brain stem:4.34 corpus callosum/glia:3.97 pineal gland:4.98 peripheral nerve:- spine:4.67 retina:- eye:- artery/aorta:4.69 vein:4.07 lymphnode:3.99 peripheral blood:- spleen:3.61 thymus:3.80 bone marrow:- adipose:3.75 bone:- skin:-
RNA-seq cerebrum:0.00 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:3.58 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:3.67 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:127.60 placenta:91.10 prostate:22.50 ovary:37.30 testis:95.20 heart:140.50 muscle:160.70 esophagus:- stomach:63.70 intestine:97.20 colon:8.50     liver/hepato:31.70        lung:63.50    bladder:- kidney:62.40 pituitary:116 thyroid/parathyroid:- adrenal gland:101.60 pancreas:88.90 breast:111.50 salivary:-
GeneChip uterus:8.65 placenta:7.53 prostate:8.64 ovary:8.68 testis:7.64 heart:8.39 muscle:10.71 esophagus:7.92 stomach:8 intestine:8.40 colon:7.95 liver/hepato:6.87 lung:8.14 bladder:- kidney:7.48 pituitary:8.90 thyroid/parathyroid:7.77 adrenal gland:8.14 pancreas:6.64 breast:8.47 salivary:7.28
CAGE uterus:4.09 placenta:3.31 prostate:3.99 ovary:3.92 testis:4.25 heart:4.54 muscle:4.81 esophagus:3.83 stomach:- intestine:3.38 colon:4.04     liver/hepato:3.25    lung:3.81 bladder:4.22 kidney:3.24 pituitary:4.62 thyroid/parathyroid:3.31 adrenal gland:- pancreas:4.01 breast:5.03 salivary:3.68
RNA-seq uterus:- placenta:- prostate:3.66 ovary:2.70 testis:4.02 heart:1.29 muscle:0.00 esophagus:- stomach:- intestine:- colon:4.12     liver/hepato:2.18        lung:3.15    bladder:- kidney:2.65 pituitary:- thyroid/parathyroid:2.96 adrenal gland:3.31 pancreas:- breast:3.99 salivary:-

Gene Information

IDs

Refseq ID NM_001142354
Gene ID 5532
Unigene ID Hs.500067
Probe set ID 202432_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000107758
GTEx ID ENSG00000107758

Orthologous Gene

Mouse[1]  NM_008914
Rat [0]  

Chromosomal Region

10q22.2  [75,196,186  -  75,255,782]

Gene Family (Interpro ID)

IPR004843  Metallophosphoesterase
IPR006186  Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase

Link to Pubmed  (Pubmed ID)

1321058
1659808
1848109
2556704
2558868
6330098
7593193
8392375
8524402
8978785
9655484
9660947
11005320
11030334
11114196
11714752
11842093
11970967
12477932
12482669
12809556
15514034
15557343
16024800
16344560
17148452
17952113
18034994
18458866
19136967
19154138
19287956
19322201
19659461
19913121
19925438
20107831
20379146
20593291
20628086
20647544
20700529
21047202
21139048
21233773
21423799
21531385
21664352
21890473
21903422
21906983
21963094
22739212
22863883
23888774
24086760
24816145

Gene Ontology  (GO ID)

Biological Process

GO:0048675  axon extension
GO:0017156  calcium ion-dependent exocytosis
GO:0016311  dephosphorylation
GO:0007507  heart development
GO:0045087  innate immune response
GO:0007612  learning
GO:0007613  memory
GO:0001915  negative regulation of T cell mediated cytotoxicity
GO:0045893  positive regulation of transcription, DNA-dependent
GO:0006470  protein amino acid dephosphorylation
GO:0006468  protein amino acid phosphorylation
GO:0050796  regulation of insulin secretion
GO:0048167  regulation of synaptic plasticity
GO:0034097  response to cytokine stimulus
GO:0007165  signal transduction
GO:0035176  social behavior
GO:0042110  T cell activation
GO:0030217  T cell differentiation
GO:0043029  T cell homeostasis
GO:0042098  T cell proliferation

Cellular Component

GO:0005955  calcineurin complex
GO:0005829  cytosol
GO:0005654  nucleoplasm
GO:0005886  plasma membrane

Molecular Function

GO:0005509  calcium ion binding
GO:0005516  calmodulin binding
GO:0033192  calmodulin-dependent protein phosphatase activity
GO:0008144  drug binding
GO:0019899  enzyme binding
GO:0005515  protein binding
GO:0046983  protein dimerization activity
GO:0030346  protein phosphatase 2B binding
GO:0004722  protein serine/threonine phosphatase activity