perforin 1 (pore forming protein)

Synonym

perforin 1 (pore forming protein), Perforin-1 precursor, PRF1, HPLH2, FLH2, Cytolysin, MGC65093, PFP, Lymphocyte pore-forming protein

normal 40 tissues
cell lines, primary cells, adult tissues and fetal tissues (FANTOM5 CAGE)

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain

blood

connective

EST

cerebrum:5.90

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:5.90

artery/aorta:-

vein:-

lymphnode:20.20

peripheral blood:236.80

spleen:1852.80

thymus:51.50

bone marrow:19.70

adipose:-

bone:12.80

skin:-

GeneChip

cerebrum:6.03

cerebellum:5.88

brain stem:6.04

corpus callosum/glia:5.98

pineal gland:-

peripheral nerve:6.28

spine:6.26

retina:-

eye:-

artery/aorta:6.49

vein:6.44

lymphnode:7.16

peripheral blood:-

spleen:9.53

thymus:7.39

bone marrow:7.37

adipose:6.96

bone:-

skin:6.66

CAGE

cerebrum:0.30

cerebellum:-

brain stem:0.84

corpus callosum/glia:0.47

pineal gland:0.14

peripheral nerve:-

spine:0.65

retina:-

eye:-

artery/aorta:1.85

vein:2.82

lymphnode:2.50

peripheral blood:-

spleen:3.51

thymus:2.53

bone marrow:-

adipose:2.41

bone:-

skin:-

RNA-seq

cerebrum:0.00

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:0.41

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:0.00

bone:-

skin:-

reproductive

muscular

alimentary

liver

lung

urinary

endo/exo-crine

EST

uterus:9.10

placenta:10.90

prostate:11.30

ovary:-

testis:-

heart:-

muscle:-

esophagus:-

stomach:-

intestine:64.80

colon:-

liver/hepato:10.60

lung:53.80

bladder:125.60

kidney:10.40

pituitary:-

thyroid/parathyroid:-

adrenal gland:50.80

pancreas:-

breast:-

salivary:-

GeneChip

uterus:6.55

placenta:6.62

prostate:6.05

ovary:6.04

testis:5.87

heart:6.40

muscle:5.99

esophagus:6.39

stomach:6.77

intestine:6.38

colon:6.86

liver/hepato:7.25

lung:8.36

bladder:-

kidney:6.21

pituitary:5.96

thyroid/parathyroid:6.22

adrenal gland:6.16

pancreas:6.23

breast:6.36

salivary:6.07

CAGE

uterus:1.58

placenta:1.57

prostate:1.70

ovary:1.29

testis:0.92

heart:1.19

muscle:0.72

esophagus:1.46

stomach:-

intestine:1.84

colon:1.85

liver/hepato:1.93

lung:3.36

bladder:1.09

kidney:1.09

pituitary:0.34

thyroid/parathyroid:1.40

adrenal gland:-

pancreas:1.21

breast:1.16

salivary:0.83

RNA-seq

uterus:-

placenta:-

prostate:0.00

ovary:0.16

testis:0.00

heart:0.00

muscle:0.00

esophagus:-

stomach:-

intestine:-

colon:0.00

liver/hepato:0.00

lung:0.13

bladder:-

kidney:0.00

pituitary:-

thyroid/parathyroid:0.00

adrenal gland:0.00

pancreas:-

breast:0.00

salivary:-

IDs

Refseq ID	NM_001083116
Gene ID	5551
Unigene ID	Hs.2200
Probe set ID	214617_at [HG-U133_Plus_2]
Ensembl ID	ENSG00000180644
GTEx ID	ENSG00000180644

Orthologous Gene

Mouse[1]	NM_011073
Rat [0]

Chromosomal Region

10q22.1 [72,357,104 - 72,362,531]

Search genes near this gene
- Between -5kb and +5kb
- Between -10kb and +10kb

LRG_94 [5,001 - 10,428]

Search genes near this gene
- Between -5kb and +5kb
- Between -10kb and +10kb

Gene Family (Interpro ID)

IPR000008	C2 calcium-dependent membrane targeting
IPR008973	C2 calcium/lipid-binding domain, CaLB
IPR018029	C2 membrane targeting protein
IPR020864	Membrane attack complex component/perforin (MACPF) domain

Gene Ontology (GO ID)

Biological Process

GO:0006915	apoptosis
GO:0006968	cellular defense response
GO:0019835	cytolysis
GO:0002357	defense response to tumor cell
GO:0051607	defense response to virus
GO:0002418	immune response to tumor cell
GO:0051260	protein homooligomerization

Cellular Component

GO:0044194	cytolytic granule
GO:0016023	cytoplasmic membrane-bounded vesicle
GO:0031904	endosome lumen
GO:0005576	extracellular region
GO:0016021	integral to membrane
GO:0005886	plasma membrane

Molecular Function

GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0022829	wide pore channel activity

perforin 1 (pore forming protein)

Synonym

Expression Pattern

Choropleth map on BodyParts3D

Classification in 40 Organs

Gene Information

IDs

Orthologous Gene

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

Cellular Component

Molecular Function