protein kinase, cAMP-dependent, catalytic, beta

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Synonym

PKA C-beta, DKFZp781I2452, protein kinase, cAMP-dependent, catalytic, beta, PKACB, MGC41879, PRKACB, MGC9320

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:591.40 cerebellum:478.60 brain stem:- corpus callosum/glia:116.60 pineal gland:296.70 peripheral nerve:122.70 spine:449.20 retina:118.60 eye:105.80 artery/aorta:60 vein:66.60 lymphnode:202.20 peripheral blood:164 spleen:18.90 thymus:412.30 bone marrow:- adipose:- bone:38.40 skin:38.40
GeneChip cerebrum:10.51 cerebellum:10.43 brain stem:10.34 corpus callosum/glia:10.22 pineal gland:- peripheral nerve:7.92 spine:9.82 retina:- eye:- artery/aorta:7.82 vein:8.31 lymphnode:8.60 peripheral blood:- spleen:8.70 thymus:9.54 bone marrow:7.54 adipose:7.45 bone:- skin:6.50
CAGE cerebrum:5.48 cerebellum:- brain stem:5.45 corpus callosum/glia:4.92 pineal gland:5.10 peripheral nerve:- spine:5.30 retina:- eye:- artery/aorta:3.46 vein:3.86 lymphnode:3.96 peripheral blood:- spleen:4.48 thymus:5.13 bone marrow:- adipose:3.97 bone:- skin:-
RNA-seq cerebrum:1.03 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:2.94 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:1.34 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:182.30 placenta:25.50 prostate:22.50 ovary:- testis:56.20 heart:127.70 muscle:20.10 esophagus:- stomach:21.20 intestine:64.80 colon:67.80     liver/hepato:10.60        lung:176    bladder:- kidney:145.60 pituitary:116 thyroid/parathyroid:- adrenal gland:- pancreas:177.80 breast:18.60 salivary:656.80
GeneChip uterus:8.20 placenta:6.07 prostate:8.71 ovary:7.91 testis:6.22 heart:7.66 muscle:6.22 esophagus:6.86 stomach:8.29 intestine:7.58 colon:7.90 liver/hepato:7.37 lung:7.58 bladder:- kidney:7.60 pituitary:9.17 thyroid/parathyroid:7.91 adrenal gland:7.43 pancreas:7.80 breast:7.70 salivary:9.59
CAGE uterus:3.66 placenta:2.77 prostate:3.99 ovary:3.50 testis:3.10 heart:3.57 muscle:2.39 esophagus:3.65 stomach:- intestine:3.45 colon:3.61     liver/hepato:3.14    lung:3.60 bladder:4.17 kidney:3.73 pituitary:5.00 thyroid/parathyroid:3.48 adrenal gland:- pancreas:2.90 breast:3.24 salivary:4.75
RNA-seq uterus:- placenta:- prostate:1.97 ovary:1.24 testis:1.27 heart:0.48 muscle:0 esophagus:- stomach:- intestine:- colon:1.30     liver/hepato:0.49        lung:1.65    bladder:- kidney:1.89 pituitary:- thyroid/parathyroid:1.39 adrenal gland:2.25 pancreas:- breast:1.95 salivary:-

Gene Information

IDs

Refseq ID NM_182948
Gene ID 5567
Unigene ID Hs.487325
Probe set ID 202741_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000142875
GTEx ID ENSG00000142875

Orthologous Gene

Mouse[8]  NM_001164198, NM_001164199, NM_001164200, NM_011100
Rat[1]  NM_001077645, NM_001164199, NM_001164200, NM_011100

Chromosomal Region

1p31.1  [84,543,745  -  84,704,181]

Gene Family (Interpro ID)

IPR000961  AGC-kinase, C-terminal
IPR000719  Protein kinase, catalytic domain
IPR011009  Protein kinase-like domain
IPR002290  Serine/threonine-protein kinase domain
IPR017442  Serine/threonine-protein kinase-like domain
IPR001245  Tyrosine-protein kinase, catalytic domain
IPR020635  Tyrosine-protein kinase, subgroup, catalytic domain

Link to Pubmed  (Pubmed ID)

1551670
1978848
2165385
2342480
7684369
7688126
7946090
8662989
9151826
9278385
9540970
9636365
9671211
9730685
9837753
10830164
11076863
11172053
11589697
12420224
12477932
12682012
12798691
12842892
12972513
14702039
14744463
15489334
15489336
15629779
15723830
16381901
16407073
16710414
16889664
16949795
17549442
17594903
18499756
18836454
19100722
19383776
19483721
19573263
19711044
19895210
19965870
20033853
20086095
20093341
20379146
20392842
20402410
20433920
20564261
21139048
21423175
21651489
21745501
21890473
21906983
21963094
21988832
22113938
22114277
22779921
22863883
22939624
22939629
23001122
23455922
24816145

Gene Ontology  (GO ID)

Biological Process

GO:0007202  activation of phospholipase C activity
GO:0034199  activation of protein kinase A activity
GO:0007596  blood coagulation
GO:0005975  carbohydrate metabolic process
GO:0071377  cellular response to glucagon stimulus
GO:0006112  energy reserve metabolic process
GO:0007173  epidermal growth factor receptor signaling pathway
GO:0008543  fibroblast growth factor receptor signaling pathway
GO:0007188  G-protein signaling, coupled to cAMP nucleotide second messenger
GO:0006094  gluconeogenesis
GO:0006006  glucose metabolic process
GO:0045087  innate immune response
GO:0051447  negative regulation of meiotic cell cycle
GO:0048011  nerve growth factor receptor signaling pathway
GO:0006468  protein amino acid phosphorylation
GO:0007243  protein kinase cascade
GO:0050796  regulation of insulin secretion
GO:0007165  signal transduction
GO:0007268  synaptic transmission
GO:0055085  transmembrane transport
GO:0019433  triglyceride catabolic process
GO:0006833  water transport

Cellular Component

GO:0005952  cAMP-dependent protein kinase complex
GO:0005813  centrosome
GO:0005829  cytosol
GO:0005654  nucleoplasm
GO:0048471  perinuclear region of cytoplasm
GO:0005886  plasma membrane

Molecular Function

GO:0005524  ATP binding
GO:0004691  cAMP-dependent protein kinase activity
GO:0000287  magnesium ion binding
GO:0005515  protein binding
GO:0031625  ubiquitin protein ligase binding