AXL receptor tyrosine kinase

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Synonym

Tyrosine-protein kinase receptor UFO precursor, AXL, AXL receptor tyrosine kinase, UFO, AXL oncogene

normal 40 tissues
cell lines, primary cells, adult tissues and fetal tissues (FANTOM5 CAGE)

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain

blood

connective

EST

cerebrum:28.40

cerebellum:25.20

brain stem:-

corpus callosum/glia:29.20

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:105.80

artery/aorta:89.90

vein:66.60

lymphnode:-

peripheral blood:-

spleen:56.70

thymus:25.80

bone marrow:-

adipose:40.30

bone:89.60

skin:105.60

GeneChip

cerebrum:6.48

cerebellum:5.40

brain stem:6.48

corpus callosum/glia:6.64

pineal gland:-

peripheral nerve:7.24

spine:7.10

retina:-

eye:-

artery/aorta:8.15

vein:8.43

lymphnode:6.50

peripheral blood:-

spleen:6.23

thymus:5.86

bone marrow:5.56

adipose:7.80

bone:-

skin:7.24

CAGE

cerebrum:3.17

cerebellum:-

brain stem:3.15

corpus callosum/glia:3.58

pineal gland:2.36

peripheral nerve:-

spine:3.38

retina:-

eye:-

artery/aorta:4.45

vein:3.86

lymphnode:2.97

peripheral blood:-

spleen:3.92

thymus:2.23

bone marrow:-

adipose:4.62

bone:-

skin:-

RNA-seq

cerebrum:1.43

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:2.04

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:4.17

bone:-

skin:-

reproductive

muscular

alimentary

liver

lung

urinary

endo/exo-crine

EST

uterus:200.50

placenta:25.50

prostate:56.30

ovary:74.50

testis:43.30

heart:255.40

muscle:-

esophagus:-

stomach:-

intestine:-

colon:8.50

liver/hepato:42.20

lung:34.20

bladder:125.60

kidney:20.80

pituitary:-

thyroid/parathyroid:-

adrenal gland:-

pancreas:8.90

breast:130.10

salivary:-

GeneChip

uterus:8.08

placenta:7.29

prostate:7.07

ovary:7.44

testis:7.72

heart:7.32

muscle:6.42

esophagus:6.87

stomach:7.12

intestine:7.06

colon:7.43

liver/hepato:5.69

lung:7.76

bladder:-

kidney:5.53

pituitary:5.66

thyroid/parathyroid:6.78

adrenal gland:7.36

pancreas:5.79

breast:7.71

salivary:5.80

CAGE

uterus:4.29

placenta:4.11

prostate:3.96

ovary:4.00

testis:4.20

heart:3.69

muscle:3.25

esophagus:4.04

stomach:-

intestine:3.49

colon:3.84

liver/hepato:3.38

lung:3.79

bladder:4.53

kidney:2.82

pituitary:2.12

thyroid/parathyroid:3.41

adrenal gland:-

pancreas:1.87

breast:4.34

salivary:2.69

RNA-seq

uterus:-

placenta:-

prostate:4.05

ovary:3.34

testis:3.78

heart:1.04

muscle:1.06

esophagus:-

stomach:-

intestine:-

colon:4.47

liver/hepato:2.16

lung:4.15

bladder:-

kidney:0.85

pituitary:-

thyroid/parathyroid:2.59

adrenal gland:3.15

pancreas:-

breast:2.54

salivary:-

IDs

Refseq ID	NM_001699
Gene ID	558
Unigene ID	Hs.590970
Probe set ID	202686_s_at [HG-U133_Plus_2]
Ensembl ID	ENSG00000167601
GTEx ID	ENSG00000167601

Orthologous Gene

Mouse[1]	NM_001190974, NM_009465
Rat[2]	NM_001013147, NM_031794

Chromosomal Region

19q13.2 [41,725,108 - 41,767,670]

Search genes near this gene
- Between -5kb and +5kb
- Between -10kb and +10kb

Gene Family (Interpro ID)

IPR003961	Fibronectin, type III
IPR008957	Fibronectin, type III-like fold
IPR000719	Protein kinase, catalytic domain
IPR011009	Protein kinase-like domain
IPR002290	Serine/threonine-protein kinase domain
IPR017442	Serine/threonine-protein kinase-like domain
IPR001245	Tyrosine-protein kinase, catalytic domain
IPR020635	Tyrosine-protein kinase, subgroup, catalytic domain

Gene Ontology (GO ID)

Biological Process

GO:0043277	apoptotic cell clearance
GO:0001974	blood vessel remodeling
GO:0048469	cell maturation
GO:0031668	cellular response to extracellular stimulus
GO:0071222	cellular response to lipopolysaccharide
GO:0007167	enzyme linked receptor protein signaling pathway
GO:0034101	erythrocyte homeostasis
GO:0021885	forebrain cell migration
GO:0006954	inflammatory response
GO:0045087	innate immune response
GO:0001779	natural killer cell differentiation
GO:0032689	negative regulation of interferon-gamma production
GO:0051250	negative regulation of lymphocyte activation
GO:0043524	negative regulation of neuron apoptosis
GO:0032720	negative regulation of tumor necrosis factor production
GO:0001764	neuron migration
GO:0042698	ovulation cycle
GO:0006909	phagocytosis
GO:0030168	platelet activation
GO:0001961	positive regulation of cytokine-mediated signaling pathway
GO:0032825	positive regulation of natural killer cell differentiation
GO:0051897	positive regulation of protein kinase B signaling cascade
GO:0043491	protein kinase B signaling cascade
GO:0032940	secretion by cell
GO:0007165	signal transduction
GO:0007283	spermatogenesis
GO:0034446	substrate adhesion-dependent cell spreading
GO:0060068	vagina development

Cellular Component

GO:0009986	cell surface
GO:0005615	extracellular space
GO:0005887	integral to plasma membrane

Molecular Function

GO:0005524	ATP binding
GO:0001786	phosphatidylserine binding
GO:0005515	protein binding
GO:0046982	protein heterodimerization activity
GO:0004714	transmembrane receptor protein tyrosine kinase activity

AXL receptor tyrosine kinase

Synonym

Expression Pattern

Choropleth map on BodyParts3D

Classification in 40 Organs

Gene Information

IDs

Orthologous Gene

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

Cellular Component

Molecular Function