lysine (K)-specific demethylase 3A

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Synonym

TSGA, KIAA0742, jumonji domain containing 1A, JHDM2A, JMJD1A, JHMD2A, DKFZp686A24246, DKFZp686P07111, JMJD1, jumonji domain containing 1, Jumonji domain-containing protein 1A

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:56.90 cerebellum:12.60 brain stem:- corpus callosum/glia:29.20 pineal gland:- peripheral nerve:- spine:- retina:355.90 eye:111.70 artery/aorta:30 vein:- lymphnode:70.80 peripheral blood:18.20 spleen:18.90 thymus:90.20 bone marrow:59 adipose:- bone:25.60 skin:57.60
GeneChip cerebrum:7.07 cerebellum:6.61 brain stem:7.13 corpus callosum/glia:7.52 pineal gland:- peripheral nerve:7.05 spine:7.58 retina:- eye:- artery/aorta:7.36 vein:7.49 lymphnode:7.48 peripheral blood:- spleen:7.55 thymus:7.99 bone marrow:7.17 adipose:7.36 bone:- skin:8.01
CAGE cerebrum:3.42 cerebellum:- brain stem:3.67 corpus callosum/glia:3.75 pineal gland:3.42 peripheral nerve:- spine:3.64 retina:- eye:- artery/aorta:3.67 vein:3.58 lymphnode:3.43 peripheral blood:- spleen:3.47 thymus:3.98 bone marrow:- adipose:3.86 bone:- skin:-
RNA-seq cerebrum:3.03 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:3.40 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:2.85 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:82 placenta:7.30 prostate:56.30 ovary:111.80 testis:242.30 heart:127.70 muscle:40.20 esophagus:- stomach:85 intestine:32.40 colon:25.40     liver/hepato:42.20        lung:73.30    bladder:376.80 kidney:20.80 pituitary:- thyroid/parathyroid:- adrenal gland:203.10 pancreas:26.70 breast:55.80 salivary:-
GeneChip uterus:7.83 placenta:7.34 prostate:7.96 ovary:7.96 testis:9.20 heart:7.40 muscle:7.11 esophagus:7.68 stomach:7.08 intestine:7.22 colon:6.28 liver/hepato:6.65 lung:7.90 bladder:- kidney:6.66 pituitary:7.14 thyroid/parathyroid:7.64 adrenal gland:7.24 pancreas:6.66 breast:7.85 salivary:6.69
CAGE uterus:3.85 placenta:3.24 prostate:3.80 ovary:3.66 testis:4.03 heart:3.65 muscle:3.70 esophagus:3.68 stomach:- intestine:3.69 colon:3.51     liver/hepato:2.72    lung:3.61 bladder:4.12 kidney:3.02 pituitary:3.64 thyroid/parathyroid:3.32 adrenal gland:- pancreas:3.10 breast:3.27 salivary:3.38
RNA-seq uterus:- placenta:- prostate:4.16 ovary:3.08 testis:4.71 heart:3.03 muscle:3.21 esophagus:- stomach:- intestine:- colon:3.13     liver/hepato:1.77        lung:3.38    bladder:- kidney:2.90 pituitary:- thyroid/parathyroid:4.03 adrenal gland:3.16 pancreas:- breast:2.72 salivary:-

Gene Information

IDs

Refseq ID NM_001146688
Gene ID 55818
Unigene ID Hs.557425
Probe set ID 212689_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000115548
GTEx ID ENSG00000115548

Orthologous Gene

Mouse[2]  NM_001038695, NM_173001
Rat [0]  

Chromosomal Region

2p11.2  [86,667,770  -  86,719,839]

Gene Family (Interpro ID)

IPR003347  Transcription factor jumonji/aspartyl beta-hydroxylase

Link to Pubmed  (Pubmed ID)

9872452
12477932
14702039
15302935
15489334
15815621
16344560
16603237
16619273
17991879
18538129
18713068
18984585
19471969
19615732
19858293
19946888
20042601
20127736
20378615
20823141
21139048
21275466
21282530
21541331
21607773
21890473
21906983
22020899
22318714
22645302
23455924
23546878
23576503
23583388
23593242
23891737
24214985
24250222

Gene Ontology  (GO ID)

Biological Process

GO:0030521  androgen receptor signaling pathway
GO:0046293  formaldehyde biosynthetic process
GO:0033169  histone H3-K9 demethylation
GO:0009755  hormone-mediated signaling pathway
GO:0051573  negative regulation of histone H3-K9 methylation
GO:0045944  positive regulation of transcription from RNA polymerase II promoter
GO:0045893  positive regulation of transcription, DNA-dependent
GO:0007290  spermatid nucleus elongation
GO:0006351  transcription, DNA-dependent

Cellular Component

GO:0005737  cytoplasm
GO:0005634  nucleus

Molecular Function

GO:0050681  androgen receptor binding
GO:0005506  iron ion binding
GO:0016702  oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
GO:0003700  transcription factor activity