protein kinase C, zeta

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Synonym

protein kinase C, zeta, nPKC-zeta, PRKCZ, PKC2, Protein kinase C zeta type

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:149.30 cerebellum:176.30 brain stem:- corpus callosum/glia:58.30 pineal gland:- peripheral nerve:61.30 spine:- retina:- eye:105.80 artery/aorta:- vein:- lymphnode:50.60 peripheral blood:- spleen:37.80 thymus:77.30 bone marrow:39.40 adipose:- bone:38.40 skin:48
GeneChip cerebrum:8.90 cerebellum:9.53 brain stem:9.01 corpus callosum/glia:7.98 pineal gland:- peripheral nerve:7.83 spine:7.89 retina:- eye:- artery/aorta:5.77 vein:5.44 lymphnode:6.81 peripheral blood:- spleen:6.90 thymus:6.33 bone marrow:5.74 adipose:5.42 bone:- skin:6.50
CAGE cerebrum:4.71 cerebellum:- brain stem:4.40 corpus callosum/glia:4.34 pineal gland:1.88 peripheral nerve:- spine:3.87 retina:- eye:- artery/aorta:1.57 vein:1.95 lymphnode:2.18 peripheral blood:- spleen:2.28 thymus:1.50 bone marrow:- adipose:0.26 bone:- skin:-
RNA-seq cerebrum:2.10 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:2.06 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0.10 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:27.30 placenta:644.80 prostate:78.90 ovary:74.50 testis:220.60 heart:63.90 muscle:- esophagus:- stomach:21.20 intestine:32.40 colon:93.30     liver/hepato:-        lung:44    bladder:- kidney:20.80 pituitary:116 thyroid/parathyroid:- adrenal gland:- pancreas:53.30 breast:139.40 salivary:-
GeneChip uterus:5.50 placenta:10.07 prostate:7.04 ovary:5.69 testis:8.77 heart:5.99 muscle:4.82 esophagus:6.91 stomach:6.16 intestine:6.45 colon:6.54 liver/hepato:6.85 lung:8 bladder:- kidney:7.62 pituitary:7.51 thyroid/parathyroid:7.77 adrenal gland:6.68 pancreas:5.65 breast:6.38 salivary:6.56
CAGE uterus:1.37 placenta:5.91 prostate:1.87 ovary:1.00 testis:3.36 heart:1.99 muscle:0.05 esophagus:2.09 stomach:- intestine:3.26 colon:2.77     liver/hepato:2.01    lung:3.16 bladder:1.30 kidney:2.26 pituitary:2.52 thyroid/parathyroid:2.97 adrenal gland:- pancreas:2.26 breast:1.36 salivary:2.12
RNA-seq uterus:- placenta:- prostate:1.62 ovary:1.48 testis:4.10 heart:1.34 muscle:0.13 esophagus:- stomach:- intestine:- colon:1.89     liver/hepato:1.31        lung:3.52    bladder:- kidney:2.70 pituitary:- thyroid/parathyroid:3.26 adrenal gland:2.11 pancreas:- breast:0.57 salivary:-

IDs

Refseq ID NM_001033582
Gene ID 5590
Unigene ID Hs.496255
Probe set ID 202178_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000067606
GTEx ID ENSG00000067606

Orthologous Gene

Mouse[2]  NM_001039079, NM_008860
Rat [0]  

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed  (Pubmed ID)

1832084
1970444
2139676
2182321
3259291
7522330
7588787
7642615
7850771
7876252
7925449
8089108
8206685
8206971
8224878
8375396
8473314
8599832
8621384
8627654
8663071
8797824
8856079
8914829
8940095
9151826
9305920
9388266
9446795
9455484
9512493
9566925
9671211
9689078
9748166
9756852
9768361
9971736
10022904
10085094
10195894
10212259
10339425
10356400
10357815
10383403
10477520
10491200
10491320
10527887
10617144
10620507
10636891
10641798
10733591
10747026
10764587
10764742
10770950
10770953
10779355
10831594
10843712
11016947
11035106
11044099
11053446
11063744
11141237
11145703
11154208
11158308
11222751
11260256
11381116
11462174
11481324
11504923
11535599
11585925
11684013
11723139
11739185
11740573
11755531
11765038
11781095
11788586
11833470
11919157
11937546
11960776
12021260
12056906
12093536
12105221
12134071
12139760
12162751
12223351
12223477
12234671
12242277
12244101
12435813
12459187
12477932
12482669
12493764
12551925
12671055
12748064
12774026
12783114
12791393
12813044
12881425
12882907
12887891
12893243
12900386
12905622
12905768
12920244
12970910
14500673
14560023
14570876
14576165
14654844
14676191
14697253
14699138
14702039
14744756
15003508
15069075
15081397
15143057
15159477
15172966
15210811
15254234
15285019
15313379
15358551
15362041
15381704
15489334
15499829
15526032
15544481
15604116
15630457
15665819
15689238
15707389
15721486
15761148
15808853
15870274
15887250
15894802
15935276
15956717
16011831
16287866
16344560
16407220
16611744
16644736
16710414
16712791
16792529
16798739
16931574
16940160
16943418
17024099
17081983
17101696
17203073
17313651
17335965
17346701
17369850
17389234
17398070
17446166
17525161
17541951
17544492
17588663
17682059
17786270
17850789
17850925
17893151
17906294
18050214
18067888
18094075
18166155
18190796
18258854
18296444
18313384
18319301
18321849
18343365
18354190
18385757
18571841
18577246
18615853
18668687
18760839
18989463
19033536
19056867
19061073
19086264
19164129
19187446
19201988
19304661
19339512
19363595
19380829
19460843
19502590
19751727
19809379
19812540
19913121
19920073
20236250
20236512
20336759
20368287
20407013
20416077
20417648
20463008
20501645
20538799
20628086
20679531
20844151
20881960
20936779
20941506
20949042
20974803
20979579
21081127
21107309
21131967
21139048
21315177
21390241
21454526
21549621
21619587
21624955
21645497
21651489
21667320
21780947
21849550
21871968
21895402
21900206
21911421
22114277
22231931
22242160
22324796
22390153
22475628
22475757
22505724
22610405
22644296
22740332
22750245
22791907
22812606
22939624
23004934
23023376
23266528
23349801
23374352
23402259
23868949
24015205
24447338
24753582

Gene Ontology  (GO ID)

Biological Process

GO:0031532  actin cytoskeleton reorganization
GO:0031584  activation of phospholipase D activity
GO:0032148  activation of protein kinase B activity
GO:0007596  blood coagulation
GO:0016477  cell migration
GO:0030010  establishment of cell polarity
GO:0006954  inflammatory response
GO:0008286  insulin receptor signaling pathway
GO:0007616  long-term memory
GO:0060291  long-term synaptic potentiation
GO:0060081  membrane hyperpolarization
GO:0000226  microtubule cytoskeleton organization
GO:0043066  negative regulation of apoptosis
GO:0051346  negative regulation of hydrolase activity
GO:0046627  negative regulation of insulin receptor signaling pathway
GO:0050732  negative regulation of peptidyl-tyrosine phosphorylation
GO:0031333  negative regulation of protein complex assembly
GO:0018105  peptidyl-serine phosphorylation
GO:0030168  platelet activation
GO:0008284  positive regulation of cell proliferation
GO:0001954  positive regulation of cell-matrix adhesion
GO:0070374  positive regulation of ERK1 and ERK2 cascade
GO:0046326  positive regulation of glucose import
GO:0046628  positive regulation of insulin receptor signaling pathway
GO:0032753  positive regulation of interleukin-4 production
GO:0051092  positive regulation of NF-kappaB transcription factor activity
GO:0045630  positive regulation of T-helper 2 cell differentiation
GO:0006468  protein amino acid phosphorylation
GO:0051291  protein heterooligomerization
GO:0070528  protein kinase C signaling cascade
GO:0007165  signal transduction
GO:0007179  transforming growth factor beta receptor signaling pathway
GO:0047496  vesicle transport along microtubule

Cellular Component

GO:0045179  apical cortex
GO:0016324  apical plasma membrane
GO:0030054  cell junction
GO:0031252  cell leading edge
GO:0005911  cell-cell junction
GO:0005737  cytoplasm
GO:0005829  cytosol
GO:0005768  endosome
GO:0016020  membrane
GO:0045121  membrane raft
GO:0005635  nuclear envelope
GO:0016363  nuclear matrix
GO:0048471  perinuclear region of cytoplasm
GO:0005886  plasma membrane
GO:0043234  protein complex
GO:0005923  tight junction

Molecular Function

GO:0005524  ATP binding
GO:0043560  insulin receptor substrate binding
GO:0043274  phospholipase binding
GO:0015459  potassium channel regulator activity
GO:0005515  protein binding
GO:0019904  protein domain specific binding
GO:0004672  protein kinase activity
GO:0019901  protein kinase binding
GO:0004697  protein kinase C activity
GO:0004674  protein serine/threonine kinase activity
GO:0008270  zinc ion binding