protein kinase C, zeta

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Synonym

protein kinase C, zeta, nPKC-zeta, PRKCZ, PKC2, Protein kinase C zeta type

normal 40 tissues
cell lines, primary cells, adult tissues and fetal tissues (FANTOM5 CAGE)

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain

blood

connective

EST

cerebrum:149.30

cerebellum:176.30

brain stem:-

corpus callosum/glia:58.30

pineal gland:-

peripheral nerve:61.30

spine:-

retina:-

eye:105.80

artery/aorta:-

vein:-

lymphnode:50.60

peripheral blood:-

spleen:37.80

thymus:77.30

bone marrow:39.40

adipose:-

bone:38.40

skin:48

GeneChip

cerebrum:8.90

cerebellum:9.53

brain stem:9.01

corpus callosum/glia:7.98

pineal gland:-

peripheral nerve:7.83

spine:7.89

retina:-

eye:-

artery/aorta:5.77

vein:5.44

lymphnode:6.81

peripheral blood:-

spleen:6.90

thymus:6.33

bone marrow:5.74

adipose:5.42

bone:-

skin:6.50

CAGE

cerebrum:4.71

cerebellum:-

brain stem:4.40

corpus callosum/glia:4.34

pineal gland:1.88

peripheral nerve:-

spine:3.87

retina:-

eye:-

artery/aorta:1.57

vein:1.95

lymphnode:2.18

peripheral blood:-

spleen:2.28

thymus:1.50

bone marrow:-

adipose:0.26

bone:-

skin:-

RNA-seq

cerebrum:0.06

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:1.05

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:0.24

bone:-

skin:-

reproductive

muscular

alimentary

liver

lung

urinary

endo/exo-crine

EST

uterus:27.30

placenta:644.80

prostate:78.90

ovary:74.50

testis:220.60

heart:63.90

muscle:-

esophagus:-

stomach:21.20

intestine:32.40

colon:93.30

liver/hepato:-

lung:44

bladder:-

kidney:20.80

pituitary:116

thyroid/parathyroid:-

adrenal gland:-

pancreas:53.30

breast:139.40

salivary:-

GeneChip

uterus:5.50

placenta:10.07

prostate:7.04

ovary:5.69

testis:8.77

heart:5.99

muscle:4.82

esophagus:6.91

stomach:6.16

intestine:6.45

colon:6.54

liver/hepato:6.85

lung:8

bladder:-

kidney:7.62

pituitary:7.51

thyroid/parathyroid:7.77

adrenal gland:6.68

pancreas:5.65

breast:6.38

salivary:6.56

CAGE

uterus:1.37

placenta:5.91

prostate:1.87

ovary:1.00

testis:3.36

heart:1.99

muscle:0.05

esophagus:2.09

stomach:-

intestine:3.26

colon:2.77

liver/hepato:2.01

lung:3.16

bladder:1.30

kidney:2.26

pituitary:2.52

thyroid/parathyroid:2.97

adrenal gland:-

pancreas:2.26

breast:1.36

salivary:2.12

RNA-seq

uterus:-

placenta:-

prostate:1.24

ovary:0.78

testis:2.51

heart:1.57

muscle:0.00

esophagus:-

stomach:-

intestine:-

colon:0.83

liver/hepato:1.03

lung:3.62

bladder:-

kidney:2.32

pituitary:-

thyroid/parathyroid:3.73

adrenal gland:1.33

pancreas:-

breast:0.84

salivary:-

IDs

Refseq ID	NM_002744
Gene ID	5590
Unigene ID	Hs.496255
Probe set ID	202178_at [HG-U133_Plus_2]
Ensembl ID	ENSG00000067606
GTEx ID	ENSG00000067606

Orthologous Gene

Mouse[2]	NM_001039079, NM_008860
Rat [0]

Chromosomal Region

1p36.33 [1,981,909 - 2,116,834]

Search genes near this gene
- Between -5kb and +5kb
- Between -10kb and +10kb

Gene Family (Interpro ID)

IPR000961	AGC-kinase, C-terminal
IPR000719	Protein kinase, catalytic domain
IPR011009	Protein kinase-like domain
IPR002290	Serine/threonine-protein kinase domain
IPR017442	Serine/threonine-protein kinase-like domain
IPR001245	Tyrosine-protein kinase, catalytic domain
IPR020635	Tyrosine-protein kinase, subgroup, catalytic domain

Gene Ontology (GO ID)

Biological Process

GO:0031532	actin cytoskeleton reorganization
GO:0031584	activation of phospholipase D activity
GO:0032148	activation of protein kinase B activity
GO:0007596	blood coagulation
GO:0016477	cell migration
GO:0030010	establishment of cell polarity
GO:0006954	inflammatory response
GO:0008286	insulin receptor signaling pathway
GO:0007616	long-term memory
GO:0060291	long-term synaptic potentiation
GO:0060081	membrane hyperpolarization
GO:0000226	microtubule cytoskeleton organization
GO:0043066	negative regulation of apoptosis
GO:0051346	negative regulation of hydrolase activity
GO:0046627	negative regulation of insulin receptor signaling pathway
GO:0050732	negative regulation of peptidyl-tyrosine phosphorylation
GO:0031333	negative regulation of protein complex assembly
GO:0018105	peptidyl-serine phosphorylation
GO:0030168	platelet activation
GO:0008284	positive regulation of cell proliferation
GO:0001954	positive regulation of cell-matrix adhesion
GO:0070374	positive regulation of ERK1 and ERK2 cascade
GO:0046326	positive regulation of glucose import
GO:0046628	positive regulation of insulin receptor signaling pathway
GO:0032753	positive regulation of interleukin-4 production
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:0045630	positive regulation of T-helper 2 cell differentiation
GO:0006468	protein amino acid phosphorylation
GO:0051291	protein heterooligomerization
GO:0070528	protein kinase C signaling cascade
GO:0007165	signal transduction
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0047496	vesicle transport along microtubule

Cellular Component

GO:0045179	apical cortex
GO:0016324	apical plasma membrane
GO:0030054	cell junction
GO:0031252	cell leading edge
GO:0005911	cell-cell junction
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005768	endosome
GO:0016020	membrane
GO:0045121	membrane raft
GO:0005635	nuclear envelope
GO:0016363	nuclear matrix
GO:0048471	perinuclear region of cytoplasm
GO:0005886	plasma membrane
GO:0043234	protein complex
GO:0005923	tight junction

Molecular Function

GO:0005524	ATP binding
GO:0043560	insulin receptor substrate binding
GO:0043274	phospholipase binding
GO:0015459	potassium channel regulator activity
GO:0005515	protein binding
GO:0019904	protein domain specific binding
GO:0004672	protein kinase activity
GO:0019901	protein kinase binding
GO:0004697	protein kinase C activity
GO:0004674	protein serine/threonine kinase activity
GO:0008270	zinc ion binding

protein kinase C, zeta

Synonym

Expression Pattern

Choropleth map on BodyParts3D

Classification in 40 Organs

Gene Information

IDs

Orthologous Gene

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

Cellular Component

Molecular Function